TRAF5 and MAP3K14

Number of citations of the paper that reports this interaction (PMID 9275204)
98

Data Source:
HPRD (in vitro, in vivo)

		TRAF5	MAP3K14
Gene Name		TNF receptor-associated factor 5	mitogen-activated protein kinase kinase kinase 14
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex	Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding	Protein Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding
	Biological Process	Apoptotic Process Signal Transduction Positive Regulation Of Cell Proliferation Protein Ubiquitination Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Immune Response I-kappaB Kinase/NF-kappaB Signaling Signal Transduction By Phosphorylation T Cell Costimulation NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Mechanical Stimulus
Pathways			Costimulation by the CD28 family CD28 co-stimulation CD28 dependent PI3K/Akt signaling Adaptive Immune System
Drugs
Diseases
GWAS			Multiple sclerosis ( 21833088)
Protein-Protein Interactions		42 interactors: CAPNS1 CCDC184 CD27 CD40 COG7 COMMD3 DGKH ENOX2 GORASP2 LTBR MAP3K14 MAP3K5 MAVS MDM2 NGFRAP1 NMI NUMBL RAD23A RIPK1 RIPK2 RNF111 SDCBP SEC13 SERPINB9 TDP2 THAP1 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF19 TNFRSF4 TNFRSF8 TRAF2 TRAF3 TRAF3IP2 TRAF6 TRIM27 TRIM37 TRIM8 USP7 ZFAND6	39 interactors: ALPL BIRC3 BRCA1 CASP8 CDC37 CHUK EDAR EEF1A1 EGFR FBL GRB10 GRB14 GRB7 HSP90AA1 HSP90AB1 IKBKAP IKBKB IKBKG MAP2K4 MAP3K7 MAP3K8 MAPK3 NFKB2 NFKBIA PEBP1 PELI3 RIPK1 RPL30 RPL4 RPL5 RPL6 RPS11 RPS13 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 ZFP91
Entrez ID		7188	9020
HPRD ID		03834	05230
Ensembl ID		ENSG00000082512
Uniprot IDs		D3DT93 O00463	Q99558
PDB IDs			4DN5 4G3D 4IDT 4IDV
Enriched GO Terms of Interacting Partners?		Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Programmed Cell Death Cell Death Death Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of JNK Cascade Cellular Response To Stimulus Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune System Process Regulation Of Protein Metabolic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Signal Transduction Regulation Of JNK Cascade Immune Response Signal Transduction Apoptotic Process Regulation Of Stress-activated MAPK Cascade Response To Tumor Necrosis Factor Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cellular Protein Metabolic Process Signaling Positive Regulation Of MAPK Cascade Cell Communication Cellular Response To Organic Substance Regulation Of Apoptotic Process Response To Stimulus Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Cytokine Production Response To Cytokine Regulation Of Phosphorylation Regulation Of Cell Death Cellular Response To Cytokine Stimulus Positive Regulation Of MAP Kinase Activity Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Response To Organic Substance Regulation Of Immunoglobulin Secretion Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Regulation Of Lymphocyte Activation Defense Response Positive Regulation Of Protein Serine/threonine Kinase Activity	TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Innate Immune Response Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Immune System Process Positive Regulation Of Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling NIK/NF-kappaB Signaling Regulation Of Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response Fc Receptor Signaling Pathway Defense Response Apoptotic Process Immune System Process Programmed Cell Death Regulation Of Protein Metabolic Process Cell Death Regulation Of Cellular Protein Metabolic Process Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Type I Interferon Production Activation Of Protein Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway
Tagcloud ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf3 traf6 transduction	alternative bcr birc3 called classical conferred dependence driven exclusive hematological ibrutinib insensitive insensitivity insights kappab lymphomas malignancy mantle mcl mutually nf nik profiling refractory sequencing sotrastaurin stratification traf2 transcriptome
Tagcloud (Difference) ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 mediators molecule much mutants necrosis residues strongly tail traf3 traf6 transduction	alternative bcr birc3 called classical conferred dependence driven exclusive hematological ibrutinib insensitive insensitivity insights lymphomas malignancy mantle mcl mutually nf nik profiling refractory sequencing sotrastaurin stratification transcriptome
Tagcloud (Intersection) ?		kappab traf2