TRAF5 and ZFAND6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TRAF5	ZFAND6
Description		TNF receptor associated factor 5	zinc finger AN1-type containing 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex	Cytoplasm Cytosol
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Signaling Adaptor Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Protein Binding Zinc Ion Binding Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding
	Biological Process	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Signal Transduction Involved In Regulation Of Gene Expression CD40 Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction MRNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-17-mediated Signaling Pathway	Protein Targeting To Peroxisome Apoptotic Process Protein Transport Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Tumor Necrosis Factor
Pathways			Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases
GWAS		Household income (MTAG) ( 31844048)	Eosinophil count ( 29403010) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 29403010) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Type 2 diabetes ( 20581827) White blood cell count ( 29403010)
Interacting Genes		63 interacting genes: BEX3 CAPNS1 CCDC184 CD27 CD40 CDC37 CIB3 COMMD3 DGKH DRC4 ENOX2 FAM9A GOLGA2 GORASP2 HSD17B10 HSF2BP LMO4 LNX1 LTBR MAP3K14 MAP3K5 MDM2 MEOX2 NMI NTAQ1 NUMBL ODF2 PIAS2 PIBF1 PICK1 PSMA1 RAD23A RIPK1 RIPK2 RNF111 RNF4 SDCBP SEC13 SERPINB9 SUMO1 TBK1 TDP2 THAP1 THAP7 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF19 TNFRSF4 TNFRSF8 TRAF2 TRAF3 TRAF3IP2 TRAF6 TRIM27 TRIM37 TRIM8 UBC USP7 YPEL5 ZFAND6 ZNF655	7 interacting genes: CDC34 DNM2 PKN1 RAD23A TRAF2 TRAF5 UBC
Entrez ID		7188	54469
HPRD ID		03834	18314
Ensembl ID		ENSG00000082512	ENSG00000086666
Uniprot IDs		O00463	Q6FIF0
PDB IDs		7L3L
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of JNK Cascade Regulation Of JNK Cascade Regulation Of Canonical NF-kappaB Signal Transduction PML Body Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Immune Response CD40 Signaling Pathway Protein Modification Process Protein Ubiquitination Post-translational Protein Modification Cytokine-mediated Signaling Pathway Tumor Necrosis Factor Receptor Activity CD40 Receptor Complex Ubiquitin Protein Ligase Activity Protein Polyubiquitination Identical Protein Binding Protein K63-linked Ubiquitination Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Cytoplasm Cell Surface Pattern Recognition Receptor Signaling Pathway Immune System Process Positive Regulation Of Cytokine Production Positive Regulation Of Intracellular Signal Transduction Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cytokine-mediated Signaling Pathway Cell Activation Ubiquitin-protein Transferase Activity JUN Kinase Kinase Kinase Activity Regulation Of Cytokine-mediated Signaling Pathway Protein Metabolic Process Regulation Of Intracellular Signal Transduction Tumor Necrosis Factor Receptor Binding Positive Regulation Of Response To Cytokine Stimulus Interleukin-17-mediated Signaling Pathway Response To Stress Protein Autoubiquitination Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Type I Interferon Production Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Signaling Adaptor Activity Intracellular Signaling Cassette Positive Regulation Of Cell Communication Adaptive Immune Response	Thioesterase Binding CD40 Receptor Complex CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Tumor Necrosis Factor Receptor Binding Signal Transduction Involved In Regulation Of Gene Expression Post-translational Protein Modification Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Catabolic Process Cytosol Endocytic Vesicle Membrane Regulation Of Immunoglobulin Production Negative Regulation Of MRNA Catabolic Process TORC2 Complex Disassembly Tumor Necrosis Factor-mediated Signaling Pathway RNA Stabilization MRNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Negative Regulation Of Membrane Tubulation Vesicle Scission Cytoplasmic Side Of Plasma Membrane Negative Regulation Of RNA Catabolic Process TRAF2-GSTP1 Complex Negative Regulation Of MRNA Metabolic Process TORC1 Complex Assembly CD40 Receptor Binding Positive Regulation Of DNA-binding Transcription Factor Activity Modification-dependent Protein Catabolic Process Histone H3T11 Kinase Activity Mitotic Cell Cycle Phase Transition Protein Catabolic Process Protein Ubiquitination Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Cell Cycle Phase Transition Cytoplasm Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane CD27 Signaling Pathway Protein Modification Process Protein Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Midbody Membrane Tubulation Regulation Of Production Of Molecular Mediator Of Immune Response Protein-containing Complex
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