TRAF5 and TNFRSF4

Number of citations of the paper that reports this interaction (PMID 9488716)
23

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro, in vivo)

		TRAF5	TNFRSF4
Gene Name		TNF receptor-associated factor 5	tumor necrosis factor receptor superfamily, member 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex	Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding	Tumor Necrosis Factor-activated Receptor Activity
	Biological Process	Apoptotic Process Signal Transduction Positive Regulation Of Cell Proliferation Protein Ubiquitination Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity	Inflammatory Response Immune Response Cellular Defense Response Positive Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cytokine Secretion Positive Regulation Of Immunoglobulin Secretion
Pathways
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		42 interactors: CAPNS1 CCDC184 CD27 CD40 COG7 COMMD3 DGKH ENOX2 GORASP2 LTBR MAP3K14 MAP3K5 MAVS MDM2 NGFRAP1 NMI NUMBL RAD23A RIPK1 RIPK2 RNF111 SDCBP SEC13 SERPINB9 TDP2 THAP1 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF19 TNFRSF4 TNFRSF8 TRAF2 TRAF3 TRAF3IP2 TRAF6 TRIM27 TRIM37 TRIM8 USP7 ZFAND6	8 interactors: SIVA1 TNFRSF9 TNFSF4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5
Entrez ID		7188	7293
HPRD ID		03834	02636
Ensembl ID		ENSG00000082512	ENSG00000186827
Uniprot IDs		D3DT93 O00463	P43489
PDB IDs			1D0A 2HEV 2HEY
Enriched GO Terms of Interacting Partners?		Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Programmed Cell Death Cell Death Death Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of JNK Cascade Cellular Response To Stimulus Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune System Process Regulation Of Protein Metabolic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Signal Transduction Regulation Of JNK Cascade Immune Response Signal Transduction Apoptotic Process Regulation Of Stress-activated MAPK Cascade Response To Tumor Necrosis Factor Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cellular Protein Metabolic Process Signaling Positive Regulation Of MAPK Cascade Cell Communication Cellular Response To Organic Substance Regulation Of Apoptotic Process Response To Stimulus Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Cytokine Production Response To Cytokine Regulation Of Phosphorylation Regulation Of Cell Death Cellular Response To Cytokine Stimulus Positive Regulation Of MAP Kinase Activity Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Response To Organic Substance Regulation Of Immunoglobulin Secretion Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Regulation Of Lymphocyte Activation Defense Response Positive Regulation Of Protein Serine/threonine Kinase Activity	Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Protein Homodimerization Activity Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immunoglobulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homotrimerization Positive Regulation Of T Cell Cytokine Production Regulation Of Cytokine Production Regulation Of Protein Homodimerization Activity Activation Of NF-kappaB-inducing Kinase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of T Cell Cytokine Production Negative Regulation Of Cytokine Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Protein Trimerization Positive Regulation Of Interleukin-2 Production Negative Regulation Of Cytokine Secretion Positive Regulation Of Cytokine Production Involved In Immune Response Signal Transduction Negative Regulation Of NF-kappaB Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Interleukin-12 Production Regulation Of Cellular Localization Positive Regulation Of Protein Binding MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Secretion Regulation Of Cytokine Production Involved In Immune Response Signaling Cell Communication Toll-like Receptor 4 Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation Cellular Response To Nitrogen Dioxide Response To Nitrogen Dioxide T-helper 2 Cell Activation Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes CD4-positive, Alpha-beta T Cell Costimulation Memory T Cell Activation Cellular Response To Tumor Necrosis Factor
Tagcloud ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf3 traf6 transduction	assembles bcl10 carma1 cbm cd134 cd252 cd28 contributor detergent dim directs expand malt1 microdomains ox40 ox40l persist pkctheta primed rafts raising rip1 signalosome superfamily tcr translocates works
Tagcloud (Difference) ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf3 traf6 transduction	assembles bcl10 carma1 cbm cd134 cd252 cd28 contributor detergent dim directs expand malt1 microdomains ox40 ox40l persist pkctheta primed rafts raising rip1 signalosome superfamily tcr translocates works
Tagcloud (Intersection) ?