TRAF5 and COMMD3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TRAF5	COMMD3
Description		TNF receptor associated factor 5	COMM domain containing 3
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex	Extracellular Region Nucleus Cytoplasm Ficolin-1-rich Granule Lumen
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Signaling Adaptor Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Signal Transduction Involved In Regulation Of Gene Expression CD40 Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction MRNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-17-mediated Signaling Pathway	Monoatomic Ion Transport Sodium Ion Transport
Pathways			Neutrophil degranulation Neddylation
Drugs
Diseases
GWAS		Household income (MTAG) ( 31844048)	Prostate-specific antigen levels ( 28139693)
Interacting Genes		63 interacting genes: BEX3 CAPNS1 CCDC184 CD27 CD40 CDC37 CIB3 COMMD3 DGKH DRC4 ENOX2 FAM9A GOLGA2 GORASP2 HSD17B10 HSF2BP LMO4 LNX1 LTBR MAP3K14 MAP3K5 MDM2 MEOX2 NMI NTAQ1 NUMBL ODF2 PIAS2 PIBF1 PICK1 PSMA1 RAD23A RIPK1 RIPK2 RNF111 RNF4 SDCBP SEC13 SERPINB9 SUMO1 TBK1 TDP2 THAP1 THAP7 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF19 TNFRSF4 TNFRSF8 TRAF2 TRAF3 TRAF3IP2 TRAF6 TRIM27 TRIM37 TRIM8 UBC USP7 YPEL5 ZFAND6 ZNF655	4 interacting genes: COMMD1 PIH1D2 TRAF5 ZNF337
Entrez ID		7188	23412
HPRD ID		03834	13082
Ensembl ID		ENSG00000082512	ENSG00000148444
Uniprot IDs		O00463	Q9UBI1
PDB IDs		7L3L	8F2R 8F2U 8P0W
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of JNK Cascade Regulation Of JNK Cascade Regulation Of Canonical NF-kappaB Signal Transduction PML Body Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Immune Response CD40 Signaling Pathway Protein Modification Process Protein Ubiquitination Post-translational Protein Modification Cytokine-mediated Signaling Pathway Tumor Necrosis Factor Receptor Activity CD40 Receptor Complex Ubiquitin Protein Ligase Activity Protein Polyubiquitination Identical Protein Binding Protein K63-linked Ubiquitination Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Cytoplasm Cell Surface Pattern Recognition Receptor Signaling Pathway Immune System Process Positive Regulation Of Cytokine Production Positive Regulation Of Intracellular Signal Transduction Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cytokine-mediated Signaling Pathway Cell Activation Ubiquitin-protein Transferase Activity JUN Kinase Kinase Kinase Activity Regulation Of Cytokine-mediated Signaling Pathway Protein Metabolic Process Regulation Of Intracellular Signal Transduction Tumor Necrosis Factor Receptor Binding Positive Regulation Of Response To Cytokine Stimulus Interleukin-17-mediated Signaling Pathway Response To Stress Protein Autoubiquitination Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Type I Interferon Production Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Signaling Adaptor Activity Intracellular Signaling Cassette Positive Regulation Of Cell Communication Adaptive Immune Response	Regulation Of DNA-binding Transcription Factor Activity R2TP Complex Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Cholesterol Import Regulation Of Cholesterol Import Positive Regulation Of Endosome To Plasma Membrane Protein Transport Regulation Of Plasma Lipoprotein Particle Levels Thioesterase Binding CD40 Receptor Complex CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Regulation Of Protein Stability Box C/D SnoRNP Assembly Sodium Channel Inhibitor Activity Positive Regulation Of Endocytic Recycling Plasma Membrane To Endosome Transport Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Sodium Ion Transport Low-density Lipoprotein Particle Clearance Cul2-RING Ubiquitin Ligase Complex Copper Ion Homeostasis Positive Regulation Of Protein Localization To Cell Surface Regulation Of Endocytic Recycling Regulation Of Cellular Response To Hypoxia Phosphatidic Acid Binding
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