TRAF5 and TNFRSF19

Number of citations of the paper that reports this interaction (PubMedID 10809768)
0

Data Source:
HPRD (in vivo)

		TRAF5	TNFRSF19
Description		TNF receptor associated factor 5	TNF receptor superfamily member 19
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex	Plasma Membrane Membrane
	Molecular Function	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Signaling Adaptor Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Tumor Necrosis Factor Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Signal Transduction Involved In Regulation Of Gene Expression CD40 Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction MRNA Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-17-mediated Signaling Pathway	Hair Follicle Development Apoptotic Process JNK Cascade Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JNK Cascade
Pathways
Drugs
Diseases
GWAS		Household income (MTAG) ( 31844048)	Blood pressure (smoking interaction) ( 25189868) Blood protein levels ( 30072576) Diabetic kidney disease ( 26305897) Heel bone mineral density ( 30598549) Hypothyroidism ( 22493691) Nasopharyngeal carcinoma ( 20512145 26545403) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		63 interacting genes: BEX3 CAPNS1 CCDC184 CD27 CD40 CDC37 CIB3 COMMD3 DGKH DRC4 ENOX2 FAM9A GOLGA2 GORASP2 HSD17B10 HSF2BP LMO4 LNX1 LTBR MAP3K14 MAP3K5 MDM2 MEOX2 NMI NTAQ1 NUMBL ODF2 PIAS2 PIBF1 PICK1 PSMA1 RAD23A RIPK1 RIPK2 RNF111 RNF4 SDCBP SEC13 SERPINB9 SUMO1 TBK1 TDP2 THAP1 THAP7 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF19 TNFRSF4 TNFRSF8 TRAF2 TRAF3 TRAF3IP2 TRAF6 TRIM27 TRIM37 TRIM8 UBC USP7 YPEL5 ZFAND6 ZNF655	9 interacting genes: GIMAP5 MTURN SGTA SGTB TRAF1 TRAF2 TRAF3 TRAF5 TRAF6
Entrez ID		7188	55504
HPRD ID		03834	05838
Ensembl ID		ENSG00000082512	ENSG00000127863
Uniprot IDs		O00463	Q9NS68
PDB IDs		7L3L
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of JNK Cascade Regulation Of JNK Cascade Regulation Of Canonical NF-kappaB Signal Transduction PML Body Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Immune Response CD40 Signaling Pathway Protein Modification Process Protein Ubiquitination Post-translational Protein Modification Cytokine-mediated Signaling Pathway Tumor Necrosis Factor Receptor Activity CD40 Receptor Complex Ubiquitin Protein Ligase Activity Protein Polyubiquitination Identical Protein Binding Protein K63-linked Ubiquitination Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Cytoplasm Cell Surface Pattern Recognition Receptor Signaling Pathway Immune System Process Positive Regulation Of Cytokine Production Positive Regulation Of Intracellular Signal Transduction Canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cytokine-mediated Signaling Pathway Cell Activation Ubiquitin-protein Transferase Activity JUN Kinase Kinase Kinase Activity Regulation Of Cytokine-mediated Signaling Pathway Protein Metabolic Process Regulation Of Intracellular Signal Transduction Tumor Necrosis Factor Receptor Binding Positive Regulation Of Response To Cytokine Stimulus Interleukin-17-mediated Signaling Pathway Response To Stress Protein Autoubiquitination Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Type I Interferon Production Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Signaling Adaptor Activity Intracellular Signaling Cassette Positive Regulation Of Cell Communication Adaptive Immune Response	Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Signaling Adaptor Activity CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity TRC Complex Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction Cytokine-mediated Signaling Pathway Identical Protein Binding Post-translational Protein Targeting To Endoplasmic Reticulum Membrane TRIF-dependent Toll-like Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of JUN Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Ubiquitin Protein Ligase Activity Regulation Of JNK Cascade Protein Targeting To ER Positive Regulation Of T Cell Cytokine Production Non-canonical NF-kappaB Signal Transduction Establishment Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of MAP Kinase Activity Positive Regulation Of Interleukin-2 Production Signal Transduction Involved In Regulation Of Gene Expression Regulation Of T Cell Cytokine Production Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Ubiquitin-protein Transferase Activity Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Endosome Membrane MRNA Transcription TORC2 Complex Disassembly Regulation Of Interleukin-2 Production Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of MAP Kinase Activity MRNA Stabilization Regulation Of Apoptotic Process
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