GNB1 and ADRA2A

Number of citations of the paper that reports this interaction (PubMedID 15782186)
0

Data Source:
BioGRID (fluorescent resonance energy transfer)

		GNB1	ADRA2A
Description		G protein subunit beta 1	adrenoceptor alpha 2A
Image
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Synapse Extracellular Exosome Photoreceptor Disc Membrane Extracellular Vesicle	Cytoplasm Plasma Membrane Membrane Basolateral Plasma Membrane Neuronal Cell Body Receptor Complex Axon Terminus Postsynaptic Membrane Presynaptic Active Zone Membrane Dopaminergic Synapse Postsynaptic Density Membrane Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	GTPase Activity Protein Binding Signaling Receptor Complex Adaptor Activity Protein-containing Complex Binding GTPase Binding	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding Alpha-1B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Thioesterase Binding Heterotrimeric G-protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding Norepinephrine Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Ras Protein Signal Transduction Cell Population Proliferation Sensory Perception Of Taste Retina Development In Camera-type Eye Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus	Positive Regulation Of Cytokine Production DNA Replication Regulation Of Smooth Muscle Contraction Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction Female Pregnancy Positive Regulation Of Cell Population Proliferation Negative Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Actin Cytoskeleton Organization Platelet Activation Positive Regulation Of Cell Migration Negative Regulation Of Epinephrine Secretion Cellular Response To Hormone Stimulus Vasodilation Glucose Homeostasis Fear Response Positive Regulation Of Potassium Ion Transport Response To Morphine Positive Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Intestinal Absorption Thermoception Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Calcium Ion Transport Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Phospholipase C-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Wound Healing Response To Alcohol Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Olfactory Signaling Pathway Olfactory Signaling Pathway Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production Sensory perception of sweet, bitter, and umami (glutamate) taste Sensory perception of sweet, bitter, and umami (glutamate) taste High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor Adrenaline,noradrenaline inhibits insulin secretion G alpha (i) signalling events G alpha (z) signalling events Surfactant metabolism
Drugs			Amphetamine Tramadol Bethanidine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Dihydroergotamine Amitriptyline Clozapine Norepinephrine Mirtazapine Phenylpropanolamine Loxapine Pramipexole Prochlorperazine Dipivefrin Prazosin Chlorpromazine Brimonidine Haloperidol Nortriptyline Amoxapine Amoxapine Lamotrigine Clonidine Lisuride Guanabenz Dexmedetomidine Trazodone Epinephrine Phentolamine Ergotamine Tizanidine Apomorphine Paroxetine Trimipramine Epinastine Tolazoline Fenoldopam Pseudoephedrine Benzphetamine Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Methyldopa Guanfacine Ergoloid mesylate Promethazine Carvedilol Nefazodone Desipramine Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra sinica root Mephentermine Yohimbine Methotrimeprazine 4-Methoxyamphetamine Dextroamphetamine Metamfetamine Periciazine Zuclopenthixol Celiprolol Dronedarone Lofexidine Epicept NP-1 Mianserin Pizotifen Asenapine Ocaperidone Droxidopa Flupirtine Esmirtazapine Xylometazoline Levonordefrin Naphazoline Tetryzoline Lurasidone Dosulepin Etoperidone Lorpiprazole Cirazoline Moxisylyte Aranidipine Moxonidine Pirlindole Pipamperone Setiptiline Racepinephrine Dihydroergocornine DL-Methylephedrine DL-Methylephedrine Xylazine Indigotindisulfonic acid Rilmenidine Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Body mass index ( 25673413 26426971) Diastolic blood pressure ( 27841878) Systolic blood pressure ( 27841878)	Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fish- and plant-related diet ( 32066663) Homeostasis model assessment of beta-cell function ( 20081858) Longitudinal alcohol consumption ( 26081443) Platelet aggregation ( 20526338 29185836)
Interacting Genes		43 interacting genes: ADRA2A ADRB2 AFP ARHGEF18 ATXN10 AVPR2 CACNA1A CACNA1B CACNA1C CDC42 CTNNA3 CYFIP1 DISC1 EPHA7 GNA12 GNAI1 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 HDAC5 KCNJ3 LCOR LINC00632 MCF2 MRGPRX1 MTNR1A MTNR1B NOL11 NR3C1 PDCL PTH1R RACK1 RASD1 RASD2 TBXA2R VAC14	14 interacting genes: ADRB1 EIF2B1 GGA3 GNAI1 GNAI2 GNAO1 GNB1 GNG2 GRK2 PPP1R9B PRKCD SNTA1 UCHL1 YWHAZ
Entrez ID		2782	150
HPRD ID		00766	00078
Ensembl ID		ENSG00000078369	ENSG00000150594
Uniprot IDs		A0A140VJJ8 B3KVK2 F6X3N5 P62873	P08913
PDB IDs		4KFM 4PNK 5HE0 5HE1 5HE2 5HE3 5UKK 5UKL 5UKM 5UZ7 6B3J 6CRK 6D9H 6DDE 6DDF 6E3Y 6EG8 6G79 6GDG 6KPF 6KPG 6LFM 6LFO 6LI3 6LMK 6LML 6M1H 6M1I 6M8S 6N4B 6NI3 6NIY 6OIJ 6OIK 6OMM 6ORV 6OS9 6OSA 6OT0 6P9X 6P9Y 6PB0 6PB1 6PT0 6UUN 6UUS 6UVA 6VCB 6VMS 6VN7 6WHA 6WHC 6WI9 6WPW 6WZG 6X18 6X19 6X1A 6XBJ 6XBK 6XBL 6XBM 6XOX 7AUE 7BB6 7BB7 7C2E 7CFM 7CFN 7CKW 7CKX 7CKY 7CKZ 7CMU 7CMV 7CRH 7CX2 7CX3 7CX4 7D76 7D77 7D7M 7DB6 7DFL 7E2X 7E2Y 7E2Z 7E32 7E33 7E9G 7E9H 7EB2 7EJ0 7EJ8 7EJA 7EJK 7EJX 7EO2 7EO4 7EPT 7EUO 7EVY 7EVZ 7EW0 7EW1 7EW2 7EW3 7EW4 7EW7 7EXD 7EZH 7EZK 7EZM 7F0T 7F1O 7F1Q 7F1R 7F1S 7F1Z 7F23 7F24 7F4D 7F4F 7F4H 7F4I 7F53 7F54 7F55 7F58 7F6G 7F6H 7F6I 7F8V 7F8W 7F9Y 7F9Z 7JHJ 7JOZ 7JV5 7JVP 7JVQ 7JVR 7K7L 7K7Z 7KH0 7KI0 7KI1 7L0P 7L0Q 7L0R 7L0S 7L1U 7L1V 7LCI 7LD3 7LD4 7LLL 7LLY 7MTS 7NA7 7NA8 7P00 7P02 7QVM 7RA3 7RAN 7RBT 7RG9 7RGP 7RKF 7RKM 7RKN 7RKX 7RKY 7RMG 7RMH 7RMI 7RTB 7RYC 7S1M 7S3I 7S8L 7S8M 7S8N 7S8O 7S8P 7SBF 7SCG 7SF7 7SF8 7SR8 7SRR 7T10 7T11 7T2G 7T2H 7T6B 7T8X 7T90 7T94 7T96 7T9I 7T9N 7TMW 7TRK 7TRP 7TRQ 7TRS 7TUZ 7TYF 7TYH 7TYI 7TYL 7TYN 7TYO 7TYW 7TYX 7TYY 7TZF 7U2K 7U2L 7UM5 7UM6 7UM7 7UTZ 7V68 7V69 7V6A 7VDH 7VDL 7VDM 7VFX 7VGX 7VIE 7VIF 7VIG 7VIH 7VKT 7VL8 7VL9 7VLA 7VUG 7VUH 7VUI 7VUJ 7VUY 7VUZ 7VV3 7VV5 7W0L 7W0M 7W0N 7W0O 7W0P 7W2Z 7W3Z 7W40 7W53 7W55 7W56 7W57 7W6P 7W7E 7WCM 7WCN 7WF7 7WJ5 7WKD 7WU2 7WU3 7WU4 7WU5 7WU9 7WUI 7WUJ 7WUQ 7WV9 7WVU 7WVV 7WVW 7WVX 7WVY 7WXU 7WXW 7WY0 7WY5 7WY8 7WYB 7WZ4 7WZ7 7X10 7X2C 7X2D 7X2F 7X2V 7X5H 7X9A 7X9B 7X9C 7X9Y 7XA3 7XBD 7XBW 7XBX 7XJJ 7XJK 7XJL 7XK2 7XK8 7XKD 7XKE 7XKF 7XMR 7XMS 7XMT 7XOU 7XOV 7XOW 7XP4 7XP5 7XP6 7XT8 7XT9 7XTA 7XTB 7XTC 7XTQ 7XV3 7XW5 7XW6 7XXH 7XXI 7XY6 7XY7 7XZ5 7XZ6 7Y1F 7Y24 7Y26 7Y27 7Y3G 7Y64 7Y65 7Y66 7Y67 7Y89 7YAC 7YAE 7YDH 7YDJ 7YDM 7YDP 7YFC 7YFD 7YK6 7YK7 7YKD 7YON 7YOO 7YP7 7YS6 8DDW 8DDX 8DPF 8DPG 8DPH 8DPI 8DWC 8DWG 8DWH 8DZP 8DZQ 8DZR 8DZS 8E3X 8E3Y 8E3Z 8E9W 8E9X 8E9Y 8E9Z 8EIT 8EJC 8EJK 8EMW 8EMX 8F0J 8F0K 8F2A 8F2B 8F76 8FEG 8FLQ 8FLR 8FLS 8FLT 8FLU 8FMZ 8FN0 8FN1 8FU6 8FX5 8FY8 8FYE 8FYL 8FYT 8FYX 8G05 8G2Y 8G59 8G94 8GAG 8GCM 8GCP 8GD9 8GDA 8GDB 8GDC 8GDZ 8GE1 8GE2 8GE3 8GE4 8GE5 8GE6 8GE7 8GE8 8GE9 8GEA 8GEB 8GEC 8GED 8GEE 8GEF 8GEG 8GEH 8GEI 8GEJ 8GFV 8GFW 8GFX 8GFY 8GFZ 8GG0 8GG1 8GG2 8GG3 8GG4 8GG5 8GG6 8GG7 8GG8 8GG9 8GGA 8GGB 8GGC 8GGE 8GGF 8GHV 8GUQ 8GUR 8GUS 8GUT 8GY7 8H0P 8H0Q 8H2G 8H4I 8H4K 8H4L 8H8J 8HBD 8HCQ 8HCX 8HDO 8HDP 8HIX 8HJ0 8HJ1 8HJ2 8HJ5 8HMP 8HMV 8HN8 8HNK 8HNL 8HNM 8HOC 8HPT 8HQC 8HQE 8HQM 8HQN 8HS3 8HSC 8HTI 8HVI 8I2G 8I7V 8I7W 8I95 8I97 8I9A 8I9L 8I9S 8IA2 8IA7 8IA8 8IBU 8IBV 8IC0 8ID3 8ID4 8ID6 8ID8 8ID9 8IEC 8IED 8IJ3 8IJA 8IJB 8IJD 8IKG 8IKH 8IKL 8INR 8IOC 8IOD 8IQ4 8IQ6 8IRR 8IRS 8IRT 8IRU 8IRV 8ITF 8IU2 8IUK 8IUL 8IUM 8IW1 8IW4 8IW7 8IW9 8IY9 8IYH 8IYS 8IYW 8IZ4 8IZB 8J18 8J19 8J1A 8J20 8J21 8J22 8J23 8J24 8J6D 8J6I 8J6J 8J6L 8J6P 8J6Q 8J6R 8J9N 8JD3 8JD5 8JD6 8JEF 8JEI 8JER 8JGB 8JGF 8JGG 8JHB 8JHI 8JHN 8JHY 8JII 8JIL 8JIM 8JJP 8JKB 8JLJ 8JLK 8JLN 8JLO 8JLP 8JLQ 8JLR 8JLZ 8JPN 8JPP 8JR9 8JSO 8JSP 8JSR 8JT6 8JXT 8JXV 8JXW 8JXX 8JZ7 8JZP 8JZZ 8K2X 8K3Z 8K4N 8K4O 8K4P 8K4S 8K6M 8K6N 8K6O 8K8J 8K9K 8K9L 8KFX 8KFY 8KFZ 8KGG 8KGK 8KH4 8KH5 8PJK 8PKM 8PM2 8POK 8QJ2 8RQL 8SAI 8SG1 8SL3 8SMV 8SZG 8SZH 8SZI 8T3O 8T3Q 8T3S 8T3V 8TB0 8THK 8THL 8TYW 8TZQ 8U02 8U1U 8U26 8U4N 8U4O 8U4P 8U4Q 8U7Z 8U81 8U82 8U83 8U84 8U8F 8UGY 8UH3 8UHB 8UNL 8UNM 8UNN 8UNO 8UNP 8UNQ 8UNR 8UNS 8UNT 8UNU 8UNV 8UNW 8UNX 8UNY 8UNZ 8UO0 8UO1 8UO2 8UO3 8UO4 8UQO 8UTD 8UUJ 8UWL 8UXV 8UXY 8UY0 8UYQ 8V6U 8VHF 8VVE 8VVF 8VVG 8VY7 8VY9 8W87 8W88 8W89 8W8A 8W8B 8W8Q 8W8R 8WC3 8WC4 8WC5 8WC6 8WC7 8WC8 8WC9 8WCA 8WCB 8WGB 8WJX 8WOG 8WP1 8WPU 8WRB 8WSS 8WST 8WW2 8WWH 8WWI 8WWJ 8WWK 8WWL 8WWM 8WWN 8X2K 8X3L 8X79 8X7A 8X8L 8X8N 8XGM 8XGO 8XGS 8XGU 8XIO 8XIP 8XIQ 8XIR 8XJK 8XJL 8XJM 8XJN 8XJO 8XML 8XOF 8XOG 8XOH 8XOI 8XOJ 8XQE 8XQF 8XQL 8XQN 8XQO 8XQP 8XQR 8XQS 8XQT 8XVE 8XVH 8XVI 8XWP 8XWQ 8XWV 8XX3 8XX6 8XX7 8XXH 8XXR 8XXU 8XXV 8XXX 8XXZ 8XYD 8XYK 8XZF 8XZG 8XZH 8XZI 8XZJ 8Y01 8Y0N 8Y45 8Y51 8Y52 8Y53 8Y62 8Y63 8YIC 8YKY 8YN2 8YN3 8YN4 8YN5 8YN6 8YN7 8YN8 8YN9 8YNA 8YRG 8YUT 8YUU 8YUV 8YW3 8YW4 8YW5 8YY8 8Z7J 8ZD1 8ZF6 8ZF9 8ZFA 8ZFC 8ZFZ 8ZJD 8ZJE 8ZJG 8ZPS 8ZPT 8ZQE 8ZR5 8ZRK 8ZSJ 8ZSP 8ZSS 8ZSV 8ZX4 8ZX5 9ASB 9AST 9AUC 9AVG 9AXF 9AYF 9B54 9B65 9BHL 9BHM 9BI6 9BIP 9BKJ 9BKK 9BQJ 9D61 9DQH 9DQJ 9EPP 9EPQ 9ERX 9EW2 9GE2 9GE3 9GYO 9IIX 9IJ9 9IQT 9ITB 9ITE 9IV1 9IV2 9IVG 9IVM 9IY8 9IYB 9IZF 9IZG 9IZH 9J31 9JKQ 9JVG 9K1C 9K1D 9K26 9K27 9L3W 9L3Y	1HLL 1HO9 1HOD 1HOF 6K42 6KUX 6KUY 7EJ0 7EJ8 7EJA 7EJK 7W6P 7W7E 9CBL 9CBM
Enriched GO Terms of Interacting Partners?		G-protein Beta-subunit Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway GTPase Activity Synapse Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Membrane Regulation Of Blood Circulation Neuronal Cell Body High Voltage-gated Calcium Channel Activity G Protein-coupled Receptor Activity Regulation Of System Process Regulation Of Biological Quality Calcium Ion Import Across Plasma Membrane Regulation Of Vasoconstriction Calcium Ion Import Into Cytosol Voltage-gated Calcium Channel Complex Norepinephrine Binding Melatonin Receptor Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Muscle System Process Regulation Of G Protein-coupled Receptor Signaling Pathway Voltage-gated Calcium Channel Activity Regulation Of Muscle Contraction Cellular Response To Oxygen-containing Compound Calcium Ion Import Inorganic Cation Import Across Plasma Membrane Midbody Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Insulin Secretion Circulatory System Process Adrenergic Receptor Activity Dendrite Negative Regulation Of Peptide Secretion Cardiac Conduction Thioesterase Binding Regulation Of Signaling Modulation Of Chemical Synaptic Transmission Monoatomic Ion Channel Complex Regulation Of Cell Communication G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Smooth Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Action Potential Regulation Of Action Potential Regulation Of Smooth Muscle Contraction Response To Amyloid-beta	Heterotrimeric G-protein Complex Alpha-2A Adrenergic Receptor Binding Response To Prostaglandin E Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Guanyl Nucleotide Binding System Process G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Plasma Membrane D2 Dopamine Receptor Binding G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase Regulator Activity Acetylcholine Receptor Signaling Pathway Response To Hormone Regulation Of The Force Of Heart Contraction By Chemical Signal Postsynaptic Signal Transduction Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Heart Contraction Membrane Regulation Of Protein Localization To Cell Cortex G Protein-coupled Receptor Binding Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Response To Ketone Cellular Response To Lipid Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Circulation Response To Alcohol Regulation Of System Process Regulation Of Biological Quality Regulation Of Relaxation Of Muscle Signal Transduction Cellular Response To Catecholamine Stimulus Negative Regulation Of Cell Communication Negative Regulation Of Signaling GTPase Activity Positive Regulation Of Superoxide Anion Generation Cellular Response To Prostaglandin E Stimulus Response To Catecholamine G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Superoxide Anion Generation Neuronal Dense Core Vesicle Regulation Of MAPK Cascade Cellular Response To Prostaglandin Stimulus Transmembrane Transporter Binding Regulation Of The Force Of Heart Contraction Negative Regulation Of Secretion By Cell
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