GNB1 and CACNA1C

Number of citations of the paper that reports this interaction (PMID 15953418)
29

Data Source:
HPRD (two hybrid)

		GNB1	CACNA1C
Gene Name		guanine nucleotide binding protein (G protein), beta polypeptide 1	calcium channel, voltage-dependent, L type, alpha 1C subunit
Image
Gene Ontology Annotations	Cellular Component	Photoreceptor Inner Segment Intracellular Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Vesicle Photoreceptor Outer Segment Membrane Cell Body Extracellular Vesicular Exosome Photoreceptor Disc Membrane	Caveolar Macromolecular Signaling Complex Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Postsynaptic Density Integral Component Of Membrane Z Disc Neuronal Cell Body Dendritic Shaft
	Molecular Function	GTPase Activity Signal Transducer Activity Protein Binding Spectrin Binding Type 1 Angiotensin Receptor Binding Protein Complex Binding GTPase Binding	Voltage-gated Calcium Channel Activity Protein Binding Calmodulin Binding High Voltage-gated Calcium Channel Activity Enzyme Binding Metal Ion Binding Alpha-actinin Binding
	Biological Process	Energy Reserve Metabolic Process Signal Transduction Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration G-protein Coupled Acetylcholine Receptor Signaling Pathway Ras Protein Signal Transduction Synaptic Transmission Blood Coagulation Phototransduction, Visible Light Cell Proliferation Cardiac Muscle Cell Apoptotic Process Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Platelet Activation Small Molecule Metabolic Process Sensory Perception Of Taste Retina Development In Camera-type Eye Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Hypoxia Cellular Response To Catecholamine Stimulus	Energy Reserve Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Axon Guidance Adult Walking Behavior Regulation Of Blood Pressure Visual Learning Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Ion-dependent Exocytosis Regulation Of Vasoconstriction Insulin Secretion Growth Hormone Secretion Regulation Of Ion Transmembrane Transport Calcium-mediated Signaling Using Extracellular Calcium Source Glucose Homeostasis Small Molecule Metabolic Process Regulation Of Organ Growth Regulation Of Insulin Secretion Smooth Muscle Contraction Involved In Micturition Calcium Ion Transport Into Cytosol Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Pathways		Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Olfactory Signaling Pathway Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Diseases associated with visual transduction Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G beta:gamma signalling through PI3Kgamma The phototransduction cascade G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Visual phototransduction Ca2+ pathway G-protein activation	NCAM1 interactions Axon guidance Integration of energy metabolism Regulation of insulin secretion NCAM signaling for neurite out-growth Adrenaline,noradrenaline inhibits insulin secretion
Drugs			Isradipine Ibutilide Amlodipine Nimodipine Nisoldipine Cinnarizine Nicardipine Magnesium Sulfate Verapamil Felodipine Nitrendipine Nifedipine Calcium Mibefradil Dronedarone Clevidipine Nilvadipine Drotaverine
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 18711365) Bipolar disorder and major depressive disorder (combined) ( 20351715) Red blood cell traits ( 23222517) Schizophrenia ( 21926974 22688191) Sleep quality ( 23728906) Warfarin maintenance dose ( 18535201)
Protein-Protein Interactions		43 interactors: ADRA2A ADRB2 ADRBK1 AFP ARHGEF18 ARRB1 ATXN10 AVPR2 CACNA1A CACNA1B CACNA1C CYFIP1 DISC1 EPHA7 GNA12 GNAS GNB2L1 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 HDAC4 HDAC5 KCNJ3 MCF2 MRGPRX1 MTNR1A MTNR1B NOL11 NR3C1 PDCL PLEKHG2 PTH1R RASD1 RASD2 TBXA2R	11 interactors: CABP1 CACNB3 COPS5 GNB1 HDAC4 PCBD1 PPM1A PRKACA RIMS1 RYR2 SRI
Entrez ID		2782	775
HPRD ID		00766	00246
Ensembl ID		ENSG00000078369
Uniprot IDs		P62873	Q13936
PDB IDs		4KFM	1T0J 2BE6 2F3Y 2F3Z 2LQC 3G43 3OXQ
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Signaling Cell Communication Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Glucagon Signal Transduction Cell Surface Receptor Signaling Pathway Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Stimulus Response To Stimulus Generation Of Precursor Metabolites And Energy Cellular Response To Hormone Stimulus Synaptic Transmission Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Peptide G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Cellular Process Response To Peptide Hormone Cell-cell Signaling Cellular Response To Organonitrogen Compound Response To Hormone Cellular Response To Organic Substance Response To Organic Substance Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Organonitrogen Compound Regulation Of Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of CAMP Metabolic Process Regulation Of Adenylate Cyclase Activity Regulation Of Signal Transduction Regulation Of Cyclase Activity Oxidation-reduction Process Regulation Of Muscle Contraction Positive Regulation Of Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Multicellular Organismal Response To Stress Regulation Of CAMP Biosynthetic Process Platelet Activation Regulation Of Insulin Secretion Chemical Homeostasis Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Peptide Hormone Secretion Cellular Process Adrenergic Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Vasoconstriction Small Molecule Metabolic Process	Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cation Channel Activity Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cellular Response To Catecholamine Stimulus Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Muscle Contraction Regulation Of Ion Transmembrane Transport Regulation Of Heart Contraction Regulation Of Intracellular Transport Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Localization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Protein Import Into Nucleus Regulation Of Binding Regulation Of Intracellular Protein Transport Regulation Of Ion Transport Regulation Of Heart Rate Regulation Of Membrane Potential Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Intracellular Protein Transport Calcium-mediated Signaling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium-mediated Signaling Using Intracellular Calcium Source Regulation Of Cell Communication By Electrical Coupling Cell Communication By Electrical Coupling Negative Regulation Of Intracellular Transport Negative Regulation Of Transport Cellular Metal Ion Homeostasis Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cell-cell Signaling Response To Epinephrine Second-messenger-mediated Signaling Cellular Cation Homeostasis Regulation Of Protein Binding Negative Regulation Of Cation Channel Activity Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Response To Organonitrogen Compound Regulation Of Ion Homeostasis
Tagcloud ?		abl alterations bcr bez235 braf canonical cdkn2a clustered coexpression confer dimer disrupt effectors encoding galpha gbeta gbetagamma gnb2 i80 interface k57 neoplasms oncogenic partly substitution subunits targetable v600k variants	ad1 ad2 ad3 aom azoxymethane bcorl1 c57bl carcinogenesis colitis colon dextran dss dysplasia foxo3 gradually irrelevant itk kcna1 microarray mir named pictar preliminarily regular rspo2 sequentially sulfate targetscan tle4
Tagcloud (Difference) ?		abl alterations bcr bez235 braf canonical cdkn2a clustered coexpression confer dimer disrupt effectors encoding galpha gbeta gbetagamma gnb2 i80 interface k57 neoplasms oncogenic partly substitution subunits targetable v600k variants	ad1 ad2 ad3 aom azoxymethane bcorl1 c57bl carcinogenesis colitis colon dextran dss dysplasia foxo3 gradually irrelevant itk kcna1 microarray mir named pictar preliminarily regular rspo2 sequentially sulfate targetscan tle4
Tagcloud (Intersection) ?