COL9A2 and COL2A1

Number of citations of the paper that reports this interaction (PMID 11724554)
4

Data Source:
HPRD (in vivo)

		COL9A2	COL2A1
Gene Name		collagen, type IX, alpha 2	collagen, type II, alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Collagen Type IX Trimer Endoplasmic Reticulum Lumen	Extracellular Region Collagen Type II Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Conferring Tensile Strength	Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Skeletal System Development Axon Guidance Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process	Skeletal System Development Cartilage Condensation Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Morphogenesis Proteoglycan Metabolic Process Axon Guidance Central Nervous System Development Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Notochord Development Inner Ear Morphogenesis Cartilage Development Palate Development Limb Bud Formation Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Otic Vesicle Development Cellular Response To BMP Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Degradation of the extracellular matrix ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: COL2A1 FEZ1 HAP1 MAG NOA1	33 interactors: ANXA5 BGN BMP2 C1QA CHAD COL6A1 COL9A1 COL9A2 COL9A3 COMP DDR1 FGF7 FN1 HTRA1 HYAL1 ITGA2B LOXL4 MAG MATN1 MMP1 MMP13 PCOLCE PDGFA PDGFB PDIA2 PKD1 PRELP RELA SPARC TGFB1 TGFBI THBS1 TNFRSF10A
Entrez ID		1298	1280
HPRD ID		00373	00361
Ensembl ID		ENSG00000049089	ENSG00000139219
Uniprot IDs		D3DPU8 Q14055	P02458
PDB IDs			1U5M 2FSE 2SEB
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Response To Growth Factor Movement Of Cell Or Subcellular Component Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Generation Of Neurons Neurogenesis Cellular Response To Organic Substance Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Regulation Of Neurogenesis Nervous System Development Regulation Of Cell Development Response To Organic Substance Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Cilium Assembly Central Nervous System Development Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cell Projection Organization Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Cell Projection Organization Locomotion Establishment Of Organelle Localization Hypothalamus Cell Differentiation Cell Differentiation Limb Bud Formation Negative Regulation Of Beta-amyloid Formation Retrograde Axon Cargo Transport Regulation Of Neuron Projection Development Axon Guidance Regulation Of Cellular Respiration Regulation Of Cell Differentiation Negative Regulation Of Macroautophagy Positive Regulation Of Neurogenesis Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Microtubule-based Movement Organelle Localization Positive Regulation Of Synaptic Transmission, GABAergic Establishment Of Mitochondrion Localization Otic Vesicle Development Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Smooth Muscle Cell Migration DNA Demethylation System Development Embryonic Skeletal Joint Morphogenesis Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Cell Development	Extracellular Matrix Organization Extracellular Structure Organization Connective Tissue Development Cartilage Development Skeletal System Development Anatomical Structure Morphogenesis Organ Morphogenesis System Development Multicellular Organismal Development Tissue Development Platelet Degranulation Anatomical Structure Development Positive Regulation Of Cell Migration Bone Development Developmental Process Positive Regulation Of Cell Motility Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Growth Plate Cartilage Development Response To Wounding Extracellular Matrix Disassembly Organ Development Skeletal System Morphogenesis Regulation Of Epithelial Cell Proliferation Cellular Response To Growth Factor Stimulus Blood Coagulation Regulation Of Body Fluid Levels Wound Healing Hemostasis Response To Growth Factor Locomotion Collagen Catabolic Process Endochondral Bone Growth Regulation Of Epithelial Cell Migration Collagen Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Involved In Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Response To External Stimulus Regulation Of Cell Migration Organ Growth Platelet Activation Regulation Of Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Growth Positive Regulation Of Endothelial Cell Migration Regulation Of Locomotion Bone Morphogenesis
Tagcloud ?		ablation aggrecan betaig cartilage chondrocyte collagen comp compensatory disturbed endochondral epiphycan epiphyseal fibronectin hypocellular interactome ix knock matn3 matrilin null oligomeric osteoarthritis proteomic tgfbeta thrombospondin underpinning xii	ablated alcian alizarin bones brdu cartilage chondrocyte chondrocytes chondrodysplasia collagens dysregulated endochondral flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones
Tagcloud (Difference) ?		ablation aggrecan betaig collagen comp compensatory disturbed epiphycan epiphyseal fibronectin hypocellular interactome ix knock matn3 matrilin null oligomeric osteoarthritis proteomic tgfbeta thrombospondin underpinning xii	ablated alcian alizarin bones brdu chondrocytes chondrodysplasia collagens dysregulated flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones
Tagcloud (Intersection) ?		cartilage chondrocyte endochondral