COL9A2 and FEZ1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		COL9A2	FEZ1
Gene Name		collagen, type IX, alpha 2	fasciculation and elongation protein zeta 1 (zygin I)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Collagen Type IX Trimer Endoplasmic Reticulum Lumen	Cytoplasm Mitochondrion Centrosome Microtubule Plasma Membrane Microtubule Cytoskeleton Axon Dendrite
	Molecular Function	Extracellular Matrix Structural Constituent Conferring Tensile Strength	Protein Kinase C Binding Protein Binding Gamma-tubulin Binding Protein N-terminus Binding
	Biological Process	Skeletal System Development Axon Guidance Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process	Transport Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Establishment Of Mitochondrion Localization Cellular Response To Growth Factor Stimulus
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Degradation of the extracellular matrix ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS			Schizophrenia ( 22688191 23894747)
Protein-Protein Interactions		5 interactors: COL2A1 FEZ1 HAP1 MAG NOA1	57 interactors: BARD1 BORA BRD1 C16orf59 C8orf33 CCL7 CIB1 CLASP2 COL9A2 CSTF2 DIS3L2 DISC1 DNAAF5 DRAP1 FEZ2 GEMIN7 GTF2F1 HAP1 HTATSF1 HTT IMMT KIAA1377 LRIF1 MEST NBR1 NDUFB9 NEK1 OLFML3 P4HB PAM16 PDCD7 PRKCZ PTH PTN PTPRS RAB3GAP1 RAB3GAP2 RAI14 RIF1 SAP30L SCOC SERPINH1 SMARCD1 SMC3 SMEK2 STAR TAC3 TAF1D TAF9 TBC1D25 TLK2 TOMM20 TTR TXNDC9 UBE4B WWC1 ZNF251
Entrez ID		1298	9638
HPRD ID		00373	09212
Ensembl ID		ENSG00000049089	ENSG00000149557
Uniprot IDs		D3DPU8 Q14055	Q99689
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Response To Growth Factor Movement Of Cell Or Subcellular Component Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Generation Of Neurons Neurogenesis Cellular Response To Organic Substance Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Regulation Of Neurogenesis Nervous System Development Regulation Of Cell Development Response To Organic Substance Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Cilium Assembly Central Nervous System Development Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cell Projection Organization Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Cell Projection Organization Locomotion Establishment Of Organelle Localization Hypothalamus Cell Differentiation Cell Differentiation Limb Bud Formation Negative Regulation Of Beta-amyloid Formation Retrograde Axon Cargo Transport Regulation Of Neuron Projection Development Axon Guidance Regulation Of Cellular Respiration Regulation Of Cell Differentiation Negative Regulation Of Macroautophagy Positive Regulation Of Neurogenesis Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Microtubule-based Movement Organelle Localization Positive Regulation Of Synaptic Transmission, GABAergic Establishment Of Mitochondrion Localization Otic Vesicle Development Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Smooth Muscle Cell Migration DNA Demethylation System Development Embryonic Skeletal Joint Morphogenesis Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Cell Development	Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Organelle Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Regulation Of Cellular Process Vesicle Transport Along Microtubule Cell Cycle Mitotic Cell Cycle Microtubule-based Process Microtubule Cytoskeleton Organization Regulation Of Metabolic Process Response To Radiation Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Heterocycle Metabolic Process Cellular Process Cellular Homeostasis Organelle Transport Along Microtubule Positive Regulation Of Metabolic Process Response To Ionizing Radiation Response To Stimulus Movement Of Cell Or Subcellular Component Cell Division Regulation Of Intracellular Signal Transduction Cell Cycle Process Regulation Of Synaptic Plasticity Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Synaptic Transmission Regulation Of Microtubule-based Process Response To Abiotic Stimulus Cellular Nitrogen Compound Metabolic Process Establishment Or Maintenance Of Cell Polarity Cellular Metabolic Process Mitotic Nuclear Division Mitotic Cell Cycle Process Homeostatic Process Regulation Of Signal Transduction Regulation Of Signaling Mitochondrial Calcium Ion Homeostasis Regulation Of Organelle Organization Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Component Organization Nitrogen Compound Metabolic Process DNA-templated Transcription, Elongation Establishment Of Protein Localization To Organelle Anatomical Structure Development Nervous System Development RNA Metabolic Process Diencephalon Development Transcription, DNA-templated
Tagcloud ?		ablation aggrecan betaig cartilage chondrocyte collagen comp compensatory disturbed endochondral epiphycan epiphyseal fibronectin hypocellular interactome ix knock matn3 matrilin null oligomeric osteoarthritis proteomic tgfbeta thrombospondin underpinning xii	atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365
Tagcloud (Difference) ?		ablation aggrecan betaig cartilage chondrocyte collagen comp compensatory disturbed endochondral epiphycan epiphyseal fibronectin hypocellular interactome ix knock matn3 matrilin null oligomeric osteoarthritis proteomic tgfbeta thrombospondin underpinning xii	atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365
Tagcloud (Intersection) ?