ARHGAP9 and TSC22D4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARHGAP9	TSC22D4
Description		Rho GTPase activating protein 9	TSC22 domain family member 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Plasma Membrane Secretory Granule Lumen	Nucleus Cytoplasm Dendrite Cell Projection Synapse
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding	Protein Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Glucose Homeostasis Negative Regulation Of DNA-templated Transcription Neuron Cellular Homeostasis Neuron Projection Extension
Pathways		Neutrophil degranulation RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494)	Brain morphology (MOSTest) ( 32665545) Platelet count ( 27863252) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		17 interacting genes: ABI3 AKT1 APP CYSRT1 FASLG FHL2 GOLGA6A GOLGA6L9 HOMEZ MRPL38 NME7 RAC1 RBPMS RUNX1T1 SMAD9 SNRPC TSC22D4	61 interacting genes: ABLIM1 AIFM1 ARHGAP9 BLZF1 CBX8 CCDC146 CCDC33 CCDC42 CCNK CDC23 CDK5R1 CKS2 CLU CTNNAL1 ENKD1 FBXW7 FRMD6 FXR2 GOLGA2 GORASP2 KPNA2 KRT40 LBP LMO1 LMO2 LNX1 LRP2BP MAD2L1 MTHFS MYLIP MYO15B NIF3L1 NOC4L NRBP1 PCBP1 PCDH17 PIH1D1 PIN1 POLR1C PPL PRKAA1 PRKAA2 PRNP PSMA1 RACK1 SACS SAT1 SMAD3 SMARCB1 SYT17 TEX11 TLE5 TRIM55 TRIM63 TSC22D1 TSPOAP1 UBLCP1 VBP1 ZBTB24 ZMYND10 ZNF580
Entrez ID		64333	81628
HPRD ID		06449	18231
Ensembl ID		ENSG00000123329	ENSG00000166925
Uniprot IDs		B3KQ74 Q9BRR9	B4DKI8 Q9Y3Q8
PDB IDs		2P0D 2P0F 2P0H
Enriched GO Terms of Interacting Partners?		Regulation Of Postsynapse Organization Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Postsynapse Sphingosine-1-phosphate Receptor Signaling Pathway Sphingolipid Mediated Signaling Pathway Regulation Of Synapse Organization Osteoblast Differentiation Response To Growth Factor SMAD Protein Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Lymphocyte Apoptotic Process T Cell Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Lamellipodium Regulation Of Fibroblast Migration Response To Nerve Growth Factor Regulation Of Protein Localization To Membrane Regulation Of TRNA Methylation Positive Regulation Of Nitric Oxide Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Amyloid-beta Complex Dendritic Shaft Regulation Of Synapse Assembly Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Dendrite Development Regulation Of Ruffle Assembly Regulation Of Lamellipodium Assembly Leukocyte Apoptotic Process Homeostatic Process Chemical Homeostasis Intracellular Signaling Cassette Negative Regulation Of Protein Localization Regulation Of Lamellipodium Organization Regulation Of Neuron Apoptotic Process Regulation Of Leukocyte Migration Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Projection Assembly Negative Regulation Of RNA Metabolic Process Response To Peptide Response To Cytokine Negative Regulation Of Protein Localization To Lysosome Acetylcholine Receptor Activator Activity Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Protein Binding Organelle Organization Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Cytoplasm Negative Regulation Of Protein Metabolic Process Regulation Of Protein Stability Negative Regulation Of Amyloid-beta Formation Cellular Response To Glucose Stimulus Phosphothreonine Residue Binding Cellular Response To Hydrogen Peroxide Protein Localization To Lipid Droplet Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of Glucose Mediated Signaling Pathway Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Carbohydrate Stimulus Organelle Disassembly Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Regulation Of Amide Metabolic Process Protein Stabilization Regulation Of Protein Metabolic Process Viral RNA Genome Replication Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Intracellular Glucose Homeostasis Protein Ubiquitination Identical Protein Binding Regulation Of Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Catabolic Process Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Response To Hydrogen Peroxide Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Ubiquitin-protein Transferase Activator Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Release Of Cytochrome C From Mitochondria
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