CYP11A1

Description		cytochrome P450 family 11 subfamily A member 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Cholesterol Monooxygenase (side-chain-cleaving) Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Iron-sulfur Protein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Metal Ion Binding
	Biological Process	Alcohol Metabolic Process Lipid Metabolic Process Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process C21-steroid Hormone Metabolic Process Sterol Metabolic Process Cortisol Metabolic Process Vitamin D Metabolic Process Cellular Response To Peptide Hormone Stimulus Steroid Hormone Biosynthetic Process
Pathways		Pregnenolone biosynthesis Endogenous sterols Defective CYP11A1 causes AICSR
Drugs		Aminoglutethimide Levoketoconazole
Diseases		Congenital adrenal hyperplasia (CAH) 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS		Coffee consumption (cups per day) ( 31837886) Craniofacial microsomia ( 26853712) Diisocyanate-induced asthma ( 25918132)
Novel Interacting Genes		1 novel interacting genes: ETFA
Interacting Genes		5 interacting genes: CYP11B2 FDX1 SMAD2 SMAD3 SMAD9
Entrez ID		1583
HPRD ID		00326
Ensembl ID		ENSG00000140459
Uniprot IDs		A0A0S2Z3R3 P05108
PDB IDs		3N9Y 3N9Z 3NA0 3NA1
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Paraxial Mesoderm Morphogenesis Mesoderm Morphogenesis Pericardium Development Trophoblast Cell Migration Transforming Growth Factor Beta Receptor Signaling Pathway Embryonic Foregut Morphogenesis Nodal Signaling Pathway Co-SMAD Binding Primary MiRNA Processing Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway R-SMAD Binding Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Transcription Regulator Complex Endoderm Development MiRNA Processing Hormone Biosynthetic Process Ureteric Bud Development Negative Regulation Of Ossification Gastrulation Mesonephric Epithelium Development Mesonephric Tubule Development Mesoderm Formation Response To Growth Factor Phosphatase Binding Electron Transfer Activity Formation Of Primary Germ Layer Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Kidney Epithelium Development Response To Transforming Growth Factor Beta Embryonic Skeletal System Morphogenesis Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Steroid Biosynthetic Process Cholesterol Metabolic Process Regulation Of Hormone Levels Steroid 11-beta-monooxygenase Activity Regulation Of Blood Volume By Renal Aldosterone Iron Ion Binding Corticosterone 18-monooxygenase Activity Electron Transport Chain Electron Transfer Flavoprotein Complex
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