CYP11A1 and CYP11B2

Number of citations of the paper that reports this interaction (PMID 10411633)
0

Data Source:
HPRD (in vitro)

		CYP11A1	CYP11B2
Gene Name		cytochrome P450, family 11, subfamily A, polypeptide 1	cytochrome P450, family 11, subfamily B, polypeptide 2
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Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Crista Perikaryon	Mitochondrion Mitochondrial Inner Membrane
	Molecular Function	Iron Ion Binding Cholesterol Monooxygenase (side-chain-cleaving) Activity Cholesterol Binding Heme Binding	Steroid 11-beta-monooxygenase Activity Iron Ion Binding Heme Binding Corticosterone 18-monooxygenase Activity
	Biological Process	C21-steroid Hormone Biosynthetic Process Progesterone Biosynthetic Process Estrogen Biosynthetic Process Xenobiotic Metabolic Process Mating Behavior Steroid Metabolic Process Cholesterol Metabolic Process Response To Salt Stress Response To Gamma Radiation Schwann Cell Differentiation Sterol Metabolic Process Response To Insecticide Biphenyl Metabolic Process Dibenzo-p-dioxin Metabolic Process Phenol-containing Compound Metabolic Process Phthalate Metabolic Process Cerebellum Development Hippocampus Development Response To Vitamin E Leydig Cell Differentiation Response To L-ascorbic Acid Response To Genistein Vitamin D Metabolic Process Response To Drug Response To Hydrogen Peroxide Response To Alkaloid Small Molecule Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Fractalkine Metabolic Process Response To Corticosterone Oxidation-reduction Process Granulosa Cell Differentiation Maternal Process Involved In Female Pregnancy Response To Fungicide Testosterone Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Antibiotic Cellular Response To Cadmium Ion Cellular Response To CAMP Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus	Regulation Of Blood Volume By Renal Aldosterone Renal Water Homeostasis C21-steroid Hormone Biosynthetic Process Mineralocorticoid Biosynthetic Process Xenobiotic Metabolic Process Steroid Metabolic Process Sterol Metabolic Process Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Biosynthetic Process Cellular Response To Potassium Ion Small Molecule Metabolic Process Potassium Ion Homeostasis Sodium Ion Homeostasis Oxidation-reduction Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Pregnenolone biosynthesis Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Mineralocorticoid biosynthesis Glucocorticoid biosynthesis Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CYP11B2 FDX1 SMAD2 SMAD3 SMAD9	3 interactors: CYP11A1 CYP11B1 FDX1
Entrez ID		1583	1585
HPRD ID		00326	00492
Ensembl ID		ENSG00000140459	ENSG00000179142
Uniprot IDs		P05108	P19099
PDB IDs		3N9Y 3N9Z 3NA0 3NA1	4DVQ 4FDH
Enriched GO Terms of Interacting Partners?		Primary MiRNA Processing SMAD Protein Complex Assembly Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Paraxial Mesoderm Morphogenesis Mesonephros Development Transforming Growth Factor Beta Receptor Signaling Pathway Kidney Epithelium Development Cellular Response To Transforming Growth Factor Beta Stimulus Nodal Signaling Pathway Response To Transforming Growth Factor Beta Embryonic Foregut Morphogenesis Foregut Morphogenesis Paraxial Mesoderm Development Production Of MiRNAs Involved In Gene Silencing By MiRNA C21-steroid Hormone Biosynthetic Process Pericardium Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Hormone Levels C21-steroid Hormone Metabolic Process Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Kidney Development Gene Silencing By MiRNA Cellular Response To DsRNA Renal System Development Posttranscriptional Gene Silencing Urogenital System Development SMAD Protein Signal Transduction Positive Regulation Of Stem Cell Differentiation Cellular Response To Organic Cyclic Compound Hormone Biosynthetic Process Regulation Of Epithelial To Mesenchymal Transition Embryonic Cranial Skeleton Morphogenesis Digestive Tract Morphogenesis Gene Silencing By RNA Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To DsRNA Endoderm Development Embryonic Pattern Specification Mesoderm Formation Skeletal System Development Mesoderm Morphogenesis Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Organic Substance Gene Silencing	C21-steroid Hormone Biosynthetic Process C21-steroid Hormone Metabolic Process Hormone Biosynthetic Process Steroid Biosynthetic Process Sterol Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Hormone Metabolic Process Steroid Metabolic Process Regulation Of Hormone Levels Alcohol Metabolic Process Lipid Biosynthetic Process Cellular Ketone Metabolic Process Cholesterol Metabolic Process Cellular Response To Metal Ion Cellular Response To Inorganic Substance Lipid Metabolic Process Response To Genistein Oxidation-reduction Process Cortisol Biosynthetic Process Granulosa Cell Differentiation Aldosterone Biosynthetic Process Fractalkine Metabolic Process Response To Metal Ion Response To Fungicide Chemokine Metabolic Process Response To Hydroxyisoflavone Testosterone Biosynthetic Process Mineralocorticoid Biosynthetic Process Phthalate Metabolic Process Cellular Response To Potassium Ion Dibenzo-p-dioxin Metabolic Process Small Molecule Metabolic Process Biphenyl Metabolic Process Glucocorticoid Biosynthetic Process Response To Potassium Ion Response To Inorganic Substance Response To L-ascorbic Acid Estrogen Biosynthetic Process Progesterone Biosynthetic Process Vitamin D Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Androgen Biosynthetic Process Cellular Response To Hormone Stimulus Response To Insecticide Cellular Response To Cadmium Ion Glucocorticoid Metabolic Process Response To Vitamin E Leydig Cell Differentiation
Tagcloud ?		aas aass abused anabolic androgenic arr19 dax1 disturbed enanthate gnrhr hsd17b4 hsd3b1 hsd3b5 insl3 intramuscular leydig lhcgr milieu oppositely prka prlr1 prlr2 prolactin star steroidogenesis steroidogenic testosterone tspo	344t accentuated adrenal aldosterone consequential constitute corroborated disequilibrium haplotype haplotypes hprt hypertension hypothesize investigators linkage milieu pathophysiological permissive polymorphism predisposes pressure proinflammatory salt serves snps stemming tg ttc
Tagcloud (Difference) ?		aas aass abused anabolic androgenic arr19 dax1 disturbed enanthate gnrhr hsd17b4 hsd3b1 hsd3b5 insl3 intramuscular leydig lhcgr oppositely prka prlr1 prlr2 prolactin star steroidogenesis steroidogenic testosterone tspo	344t accentuated adrenal aldosterone consequential constitute corroborated disequilibrium haplotype haplotypes hprt hypertension hypothesize investigators linkage pathophysiological permissive polymorphism predisposes pressure proinflammatory salt serves snps stemming tg ttc
Tagcloud (Intersection) ?		milieu