CYP11A1 and CYP11B2

Number of citations of the paper that reports this interaction (PubMedID 10411633)
0

Data Source:
HPRD (in vitro)

		CYP11A1	CYP11B2
Description		cytochrome P450 family 11 subfamily A member 1	cytochrome P450 family 11 subfamily B member 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane	Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Cholesterol Monooxygenase (side-chain-cleaving) Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Iron-sulfur Protein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Metal Ion Binding	Monooxygenase Activity Steroid 11-beta-monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Metal Ion Binding Corticosterone 18-monooxygenase Activity
	Biological Process	Alcohol Metabolic Process Lipid Metabolic Process Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process C21-steroid Hormone Metabolic Process Sterol Metabolic Process Cortisol Metabolic Process Vitamin D Metabolic Process Cellular Response To Peptide Hormone Stimulus Steroid Hormone Biosynthetic Process	Regulation Of Blood Volume By Renal Aldosterone Renal Water Homeostasis Alcohol Metabolic Process Lipid Metabolic Process Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Mineralocorticoid Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Metabolic Process Cortisol Biosynthetic Process Cellular Response To Potassium Ion Potassium Ion Homeostasis Sodium Ion Homeostasis Cellular Response To Peptide Hormone Stimulus
Pathways		Pregnenolone biosynthesis Endogenous sterols Defective CYP11A1 causes AICSR	Mineralocorticoid biosynthesis Glucocorticoid biosynthesis Endogenous sterols Defective CYP11B2 causes CMO-1 deficiency
Drugs		Aminoglutethimide Levoketoconazole	Spironolactone Levoketoconazole Osilodrostat
Diseases		Congenital adrenal hyperplasia (CAH) 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)	Aldosterone synthase deficiency; Corticosterone methyloxidase type I deficiency; Corticosterone methyloxidase type II deficiency Glucocorticoid-remediable aldosteronism (GRA)
GWAS		Coffee consumption (cups per day) ( 31837886) Craniofacial microsomia ( 26853712) Diisocyanate-induced asthma ( 25918132)	Diastolic blood pressure ( 27841878 30487518) Hypertension ( 30487518 32709000) Mean arterial pressure ( 29403010 30487518) Medication use (diuretics) ( 31015401) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Pulse pressure ( 30487518) Systolic blood pressure ( 27841878 29403010 30487518 30578418)
Interacting Genes		5 interacting genes: CYP11B2 FDX1 SMAD2 SMAD3 SMAD9	3 interacting genes: CYP11A1 CYP11B1 FDX1
Entrez ID		1583	1585
HPRD ID		00326	00492
Ensembl ID		ENSG00000140459	ENSG00000179142
Uniprot IDs		A0A0S2Z3R3 P05108	P19099
PDB IDs		3N9Y 3N9Z 3NA0 3NA1	4DVQ 4FDH 4ZGX 6XZ8 6XZ9 7M8I 7M8V
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Paraxial Mesoderm Morphogenesis Mesoderm Morphogenesis Pericardium Development Trophoblast Cell Migration Transforming Growth Factor Beta Receptor Signaling Pathway Embryonic Foregut Morphogenesis Nodal Signaling Pathway Co-SMAD Binding Primary MiRNA Processing Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway R-SMAD Binding Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Transcription Regulator Complex Endoderm Development MiRNA Processing Hormone Biosynthetic Process Ureteric Bud Development Negative Regulation Of Ossification Gastrulation Mesonephric Epithelium Development Mesonephric Tubule Development Mesoderm Formation Response To Growth Factor Phosphatase Binding Electron Transfer Activity Formation Of Primary Germ Layer Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Kidney Epithelium Development Response To Transforming Growth Factor Beta Embryonic Skeletal System Morphogenesis Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Steroid Biosynthetic Process Cholesterol Metabolic Process Regulation Of Hormone Levels Steroid 11-beta-monooxygenase Activity Regulation Of Blood Volume By Renal Aldosterone Iron Ion Binding Corticosterone 18-monooxygenase Activity Electron Transport Chain Electron Transfer Flavoprotein Complex	Hormone Biosynthetic Process Cholesterol Metabolic Process Iron Ion Binding Glucocorticoid Biosynthetic Process Steroid Biosynthetic Process Cortisol Metabolic Process Sterol Metabolic Process C21-steroid Hormone Biosynthetic Process Hormone Metabolic Process Glucocorticoid Metabolic Process Steroid Metabolic Process Alcohol Metabolic Process C21-steroid Hormone Metabolic Process Steroid Hormone Biosynthetic Process Lipid Biosynthetic Process Regulation Of Hormone Levels Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Monooxygenase Activity Ketone Metabolic Process Cellular Response To Oxygen-containing Compound Heme Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Iron-sulfur Protein As One Donor, And Incorporation Of One Atom Of Oxygen Cholesterol Monooxygenase (side-chain-cleaving) Activity Olefinic Compound Metabolic Process Lipid Metabolic Process Cellular Response To Peptide Hormone Stimulus Steroid 11-beta-monooxygenase Activity Corticosterone 18-monooxygenase Activity P450-containing Electron Transport Chain Aldosterone Biosynthetic Process Small Molecule Metabolic Process Mineralocorticoid Biosynthetic Process Mitochondrion Aldosterone Metabolic Process Cortisol Biosynthetic Process Response To Peptide Hormone Cellular Response To Hormone Stimulus Mitochondrial Matrix Mitochondrial Inner Membrane Vitamin D Metabolic Process Cellular Response To Potassium Ion Cellular Response To Forskolin Steroid Hydroxylase Activity Oxidoreductase Activity Response To Forskolin Regulation Of Biological Quality Response To Potassium Ion Response To Hormone 2 Iron, 2 Sulfur Cluster Binding Ketone Biosynthetic Process
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