NR3C1 and CALR

Number of citations of the paper that reports this interaction (PubMedID 8107808)
0

Data Source:
HPRD (in vivo)

		NR3C1	CALR
Description		nuclear receptor subfamily 3 group C member 1	calreticulin
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Mitochondrion Mitochondrial Matrix Centrosome Spindle Cytosol Cytoskeleton Membrane Nuclear Speck Protein-containing Complex Synapse	Acrosomal Vesicle Extracellular Region Extracellular Space Nucleus Nuclear Envelope Cytoplasm Mitochondrion Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion External Side Of Plasma Membrane Cell Surface Endomembrane System Membrane Sarcoplasmic Reticulum Phagocytic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex Cytolytic Granule Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm Cortical Granule Extracellular Exosome Endocytic Vesicle Lumen Lumenal Side Of Endoplasmic Reticulum Membrane Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Nuclear Receptor Activity Nuclear Glucocorticoid Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Lipid Binding TBP-class Protein Binding Protein Kinase Binding Estrogen Response Element Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Hsp90 Protein Binding Steroid Hormone Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Complement Component C1q Complex Binding DNA Binding RNA Binding MRNA Binding Nuclear Export Signal Receptor Activity Integrin Binding Iron Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Carbohydrate Binding Ubiquitin Protein Ligase Binding Peptide Binding Hormone Binding Protein Folding Chaperone Metal Ion Binding Nuclear Androgen Receptor Binding Unfolded Protein Binding Protein-folding Chaperone Binding Molecular Sequestering Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gluconeogenesis Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Chromosome Segregation Signal Transduction Glucocorticoid Metabolic Process Response To Wounding Gene Expression Microglia Differentiation Adrenal Gland Development Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Glucocorticoid Biosynthetic Process Nuclear Receptor-mediated Corticosteroid Signaling Pathway Synaptic Transmission, Glutamatergic Maternal Behavior Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Differentiation Cell Division Response To Glucocorticoid Response To Cortisol Mammary Gland Duct Morphogenesis Motor Behavior Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Neuroinflammatory Response Response To Ketone Positive Regulation Of MiRNA Transcription	Negative Regulation Of Transcription By RNA Polymerase II Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of DNA-templated Transcription Protein Folding Protein Export From Nucleus Intracellular Calcium Ion Homeostasis Spermatogenesis Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Translation Cortical Actin Cytoskeleton Organization Response To Estradiol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Testosterone Protein Localization To Nucleus Protein Folding In Endoplasmic Reticulum ERAD Pathway Regulation Of Meiotic Nuclear Division Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Phagocytosis Protein Stabilization Sequestering Of Calcium Ion Protein Maturation Cardiac Muscle Cell Differentiation Cellular Response To Electrical Stimulus Cellular Response To Lithium Ion Cellular Senescence Cellular Response To Virus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Trophoblast Cell Migration Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Response To Peptide Response To Glycoside Response To Biphenyl Positive Regulation Of Dendritic Cell Chemotaxis
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand SUMOylation of intracellular receptors PTK6 Expression Regulation of RUNX2 expression and activity FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Potential therapeutics for SARS Regulation of NPAS4 gene transcription	ER-Phagosome pathway Assembly of Viral Components at the Budding Site Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors ATF6 (ATF6-alpha) activates chaperone genes Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Flunisolide Diflorasone Alclometasone Medrysone Amcinonide Fluorometholone Megestrol acetate Levonorgestrel Beclomethasone dipropionate Progesterone Spironolactone Betamethasone Desoximetasone Fluticasone propionate Fluocinolone acetonide Ulobetasol Triamcinolone Prednisone Flumethasone Fludrocortisone Norethisterone Hydrocortisone Mometasone Hydrocortamate Mifepristone Clocortolone Flurandrenolide Prednisolone Loteprednol etabonate Rimexolone Methylprednisolone Clobetasol propionate Fluocinonide Prednicarbate Fluoxymesterone Budesonide Dexamethasone Desonide Cortisone acetate Paramethasone Drospirenone Ciclesonide Hexane-1,6-Diol Aldosterone ORG-34517 Difluprednate Ulipristal Fluticasone furoate Tixocortol Difluocortolone Gestrinone Deflazacort Onapristone Cortivazol Clobetasone Fluticasone Mometasone furoate Hydrocortisone aceponate Hydrocortisone acetate Hydrocortisone butyrate Hydrocortisone cypionate Hydrocortisone phosphate Hydrocortisone probutate Hydrocortisone valerate Segesterone acetate Prednisolone phosphate Dexamethasone acetate Betamethasone phosphate Prednisolone acetate	Antihemophilic factor, human recombinant Tenecteplase Melatonin Lanoteplase Copper Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate
Diseases		46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
GWAS		Appendicular lean mass ( 33097823) Atrial fibrillation ( 29892015 30061737) Hip circumference adjusted for BMI ( 34021172) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Night sleep phenotypes ( 27126917) PR interval ( 32439900) Spatial processing ( 31596458)	Clozapine-induced agranulocytosis ( 25187353) Estimated glomerular filtration rate ( 31152163) Platelet count ( 32888494) Red blood cell traits ( 23222517)
Interacting Genes		167 interacting genes: ABCC1 ADA AR ARPC5 BAG1 C1orf94 CALM1 CALR CEBPA CEBPB CENPB CHD9 COPS6 CREB1 CREBBP DAP3 DAPK1 DCAF6 DDX54 DNMT3L DOCK3 DTD1 ECD EFHC2 EGFR EP300 EPB41L1 ETS1 ETS2 FAM161B FKBP4 FTH1 FYN GNB1 GNB2 GRIP1 H3C1 HDAC1 HDAC6 HMGB1 HMGB2 HMOX2 HNRNPA1 HNRNPU HSP90AA1 HSP90AB1 HSPA1A HSPD1 IDE IFNGR2 JMJD1C JUN KAT5 KDM5A KPNA2 KRTCAP3 LCK LCOR LPXN LRIF1 MAFF MAPK1 MAPK15 MAPK8 MDM2 MED1 MED14 MED25 MSX2 NCL NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NEDD4L NFKB1 NFKB2 NR0B1 NR0B2 NR1H3 NR2E3 NR2F2 NR2F6 NR3C2 NR4A1 NRIP1 NUP54 ONECUT1 OSGEP PBX1 PELP1 PIAS2 POLR1D POU1F1 POU2F1 POU2F2 PPARGC1A PRDX3 PRKACA PRKDC PRPF6 PSMC3IP PTGES3 PTMS RACK1 RAD54L2 RAD9A RAF1 RAN RARA RBM14 RELA RFPL2 RNF14 RXRB SFN SGTA SHKBP1 SLC25A4 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCD1 SMARCE1 SPIN2A SRA1 SRC STAT3 STAT5A STAT5B STRN3 STUB1 SUMO1 SUMO4 SVIL SYT1 TADA2A TBP TDG TGFB1I1 TMF1 TNS4 TP53 TRIM24 TRIM28 TSG101 TXN UBB UBE2I UBE2L3 UBE3A UBR1 UBR5 UHRF1 USP2 WTIP YWHAH ZBTB16 ZBTB20 ZBTB3 ZBTB9 ZNF496	50 interacting genes: APOB APP AR B2M CD1D F5 F8 FBN1 FGB GSC2 HLA-C HLA-E ITGA2B ITGA3 ITGAV LPL LRIF1 LRP1 MAPK6 MBL2 MTNR1A NKX2-1 NR3C1 OGT PDE4B PDIA2 PDIA3 PLAT PLP1 PRF1 PTPN11 RNY1 RNY3 RNY4 SCARF1 SGTB SIRPA SLC2A1 SLC6A4 SMARCB1 SQSTM1 SUMO4 TAF1B TAPBP TF THBS1 TSHR UBE3A UPF2 VWF
Entrez ID		2908	811
HPRD ID		00679	00169
Ensembl ID		ENSG00000113580	ENSG00000179218
Uniprot IDs		E5KQF5 E5KQF6 F1D8N4 P04150	P27797 V9HW88
PDB IDs		1M2Z 1NHZ 1P93 3BQD 3CLD 3E7C 3H52 3K22 3K23 4CSJ 4HN5 4HN6 4LSJ 4MDD 4P6W 4P6X 4UDC 4UDD 5CBX 5CBY 5CBZ 5CC1 5E69 5E6A 5E6B 5E6C 5E6D 5EMC 5EMP 5EMQ 5G3J 5G5W 5NFP 5NFT 5UC1 5UC3 5VA0 5VA7 6BQU 6CFN 6DXK 6EL6 6EL7 6EL9 6X6D 6X6E 6YMO 6YO8 6YOS 7KRJ 7KW7 7PRV 7PRW 7PRX 8A9G 8FFV 8FFW 8VKZ	2CLR 3DOW 3POS 3POW 5LK5 5V90 6ENY 7QPD 8TZO 8TZR
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Nucleoplasm Nucleus Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Transcription Coactivator Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Response To Lipid Negative Regulation Of Biosynthetic Process Chromatin Binding Response To Hormone Nuclear Receptor-mediated Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nuclear Receptor Binding Nuclear Glucocorticoid Receptor Binding Intracellular Signal Transduction Transcription Cis-regulatory Region Binding Protein-containing Complex Hormone-mediated Signaling Pathway Transcription Regulator Complex Enzyme Binding Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cellular Response To Hormone Stimulus	Cell Surface Integrin Binding External Side Of Plasma Membrane Platelet Alpha Granule Cell Adhesion Endoplasmic Reticulum Lumen Antigen Processing And Presentation Of Endogenous Antigen Cell-cell Adhesion Platelet Alpha Granule Lumen Extracellular Space Cellular Response To Oxygen-containing Compound Positive Regulation Of Immune System Process Signaling Receptor Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Regulation Of Extrinsic Apoptotic Signaling Pathway Extracellular Exosome Antibacterial Humoral Response Negative Regulation Of Signaling Negative Regulation Of Cell Communication Immune System Process MHC Class I Peptide Loading Complex Positive Regulation Of Cell Killing MHC Class I Protein Complex Peptide Antigen Assembly With MHC Class I Protein Complex Positive Regulation Of Gene Expression Response To Hormone Reproductive Behavior Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Response To Stress Negative Regulation Of Multicellular Organismal Process Tapasin-ERp57 Complex Positive Regulation Of Endocytosis Regulation Of T Cell Mediated Cytotoxicity Regulation Of Leukocyte Mediated Cytotoxicity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process Platelet Aggregation Negative Regulation Of Signal Transduction Regulation Of Tumor Necrosis Factor Production Blood Coagulation Cellular Response To Amyloid-beta Apolipoprotein Binding Coagulation Signaling Receptor Activity Positive Regulation Of Cell Adhesion Positive Regulation Of Tumor Necrosis Factor Production Heparan Sulfate Proteoglycan Binding
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