NR3C1 and ETS2

Number of citations of the paper that reports this interaction (PMID 11279115)
7

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		NR3C1	ETS2
Gene Name		nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	v-ets avian erythroblastosis virus E26 oncogene homolog 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Cytosol Membrane	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Glucocorticoid Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Glucocorticoid-activated RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Protein Dimerization Activity Steroid Hormone Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Glucocorticoid Receptor Binding
	Biological Process	Regulation Of Gluconeogenesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Glucocorticoid Metabolic Process Gene Expression Chromatin Modification Adrenal Gland Development Regulation Of Glucocorticoid Biosynthetic Process Maternal Behavior Glucocorticoid Receptor Signaling Pathway Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Mammary Gland Duct Morphogenesis Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Glucocorticoid Mediated Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression	Cellular Senescence Oncogene Induced Senescence
Drugs		Flunisolide Diflorasone Alclometasone Medrysone Amcinonide Fluorometholone Megestrol Beclometasone dipropionate Betamethasone Desoximetasone Fluticasone Propionate Fluocinolone Acetonide Halobetasol Propionate Triamcinolone Prednisone Flumethasone Pivalate Fludrocortisone Hydrocortisone Mometasone Hydrocortamate Mifepristone Clocortolone Flurandrenolide Prednisolone Loteprednol Rimexolone Methylprednisolone Clobetasol Fluocinonide Prednicarbate Fluoxymesterone Budesonide Dexamethasone Desonide Cortisone acetate Paramethasone Ciclesonide Hexane-1,6-Diol Difluprednate Fluticasone furoate
Diseases
GWAS			Non-small cell lung cancer ( 21079520)
Protein-Protein Interactions		135 interactors: ADA AR ARPC5 BAG1 CALM1 CALR CEBPA CEBPB CENPB CHD9 COPS6 CREB1 CREBBP DAP3 DAXX DCAF6 DDX54 ECD ETS1 ETS2 FKBP4 FTH1 FYN GNB1 GNB2 GNB2L1 GRIP1 HDAC6 HMGB1 HMGB2 HMOX2 HNRNPA1 HNRNPU HSP90AA1 HSPA1A HSPD1 IDE IFNGR2 JUN KAT5 KDM5A KPNA2 LCK LRIF1 MAFF MAPK1 MAPK15 MAPK8 MDM2 MED1 MED14 MED25 MSX2 NCL NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NEDD4L NFKB1 NFKB2 NR0B1 NR1H3 NR2E3 NR2F2 NR2F6 NR3C2 NR4A1 NRIP1 ONECUT1 OSGEP PBX1 PELP1 PIAS2 PML POLR1D POU1F1 POU2F1 POU2F2 PPARGC1A PRKACA PRKDC PRPF6 PSMC3IP PTGES3 PTMS RAD54L2 RAD9A RAF1 RAN RARA RBM14 RELA RNF14 RXRB SFN SLC25A4 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCD1 SMARCE1 SRA1 SRC STAT3 STAT5A STAT5B SUMO1 SUMO4 SVIL SYT1 TADA2A TBP TDG TGFB1I1 TMF1 TP53 TRIM24 TRIM28 TSG101 TXN UBB UBE2I UBE2L3 YWHAH ZBTB16 ZBTB20 ZBTB3 ZBTB9 ZNF496	20 interactors: CDK10 CREBBP EP300 ERG ETS1 FOS GATA3 JUN NCOR1 NR3C1 POU5F1 RFWD2 SMARCA4 SPI1 SRA1 SRC STAT5B TDP2 ZFYVE9 ZMYND11
Entrez ID		2908	2114
HPRD ID		00679	01263
Ensembl ID		ENSG00000113580	ENSG00000157557
Uniprot IDs		B7Z7I2 E5KQF5 E5KQF6 F1D8N4 P04150	P15036
PDB IDs		1M2Z 1NHZ 1P93 3BQD 3CLD 3E7C 3H52 3K22 3K23 4HN5 4HN6	4BQA 4MHV
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Gene Expression RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Cellular Metabolic Process Cellular Response To Hormone Stimulus Biosynthetic Process Regulation Of Cellular Process Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Androgen Receptor Signaling Pathway Response To Steroid Hormone Response To Organic Cyclic Compound Transcription Initiation From RNA Polymerase II Promoter Response To Lipid DNA-templated Transcription, Initiation Cell Differentiation	Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Cell Cycle Regulation Of Signal Transduction Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Myeloid Cell Differentiation Positive Regulation By Host Of Viral Transcription Response To Steroid Hormone Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of Signaling Gland Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Nitrogen Compound Metabolic Process Response To Lipid Biosynthetic Process Leukocyte Differentiation Immune System Process Cellular Response To Growth Factor Stimulus Regulation Of Myeloid Cell Differentiation Response To Organic Cyclic Compound Tissue Development
Tagcloud ?		2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide cdkn1c ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 phosphoinositide propionate reporter rgs2 ru24858 suboptimal tsc22d3 viii	3t3 activates ap blocked colony confirming constitutive cotransfected cotransfection dominant downstream erbb families focus mutants neu neut nih oncogenic parallel points raf ras reporter residue threonine transforming transmembrane
Tagcloud (Difference) ?		2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide cdkn1c ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 phosphoinositide propionate rgs2 ru24858 suboptimal tsc22d3 viii	3t3 activates ap blocked colony confirming constitutive cotransfected cotransfection dominant downstream erbb families focus mutants neu neut nih oncogenic parallel points raf ras residue threonine transforming transmembrane
Tagcloud (Intersection) ?		reporter