NR3C1 and HSPD1

Number of citations of the paper that reports this interaction (PubMedID 10508170)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		NR3C1	HSPD1
Description		nuclear receptor subfamily 3 group C member 1	heat shock protein family D (Hsp60) member 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Mitochondrion Mitochondrial Matrix Centrosome Spindle Cytosol Cytoskeleton Membrane Nuclear Speck Protein-containing Complex Synapse	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Early Endosome Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Membrane Coated Vesicle Secretory Granule Protein-containing Complex Intracellular Membrane-bounded Organelle Lipopolysaccharide Receptor Complex Extracellular Exosome Sperm Midpiece Sperm Plasma Membrane Migrasome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Nuclear Receptor Activity Nuclear Glucocorticoid Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Lipid Binding TBP-class Protein Binding Protein Kinase Binding Estrogen Response Element Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Hsp90 Protein Binding Steroid Hormone Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Nucleotide Binding Lipopolysaccharide Binding P53 Binding DNA Replication Origin Binding Single-stranded DNA Binding RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding High-density Lipoprotein Particle Binding Isomerase Activity ATP Hydrolysis Activity Enzyme Binding Ubiquitin Protein Ligase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Unfolded Protein Binding Protein-folding Chaperone Binding Cysteine-type Endopeptidase Activator Activity ATP-dependent Protein Folding Chaperone
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gluconeogenesis Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Chromosome Segregation Signal Transduction Glucocorticoid Metabolic Process Response To Wounding Gene Expression Microglia Differentiation Adrenal Gland Development Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Glucocorticoid Biosynthetic Process Nuclear Receptor-mediated Corticosteroid Signaling Pathway Synaptic Transmission, Glutamatergic Maternal Behavior Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Differentiation Cell Division Response To Glucocorticoid Response To Cortisol Mammary Gland Duct Morphogenesis Motor Behavior Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Neuroinflammatory Response Response To Ketone Positive Regulation Of MiRNA Transcription	Positive Regulation Of Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Protein Folding 'de Novo' Protein Folding Response To Unfolded Protein Apoptotic Mitochondrial Changes Response To Cold Positive Regulation Of Interferon-alpha Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Mitochondrial Unfolded Protein Response Protein Refolding B Cell Proliferation T Cell Activation B Cell Activation Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Adhesion Of Symbiont To Host Protein Import Into Mitochondrial Intermembrane Space Isotype Switching To IgG Isotypes Protein Stabilization Positive Regulation Of T Cell Activation Chaperone-mediated Protein Complex Assembly Protein Maturation Biological Process Involved In Interaction With Symbiont Cellular Response To Interleukin-7 Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand SUMOylation of intracellular receptors PTK6 Expression Regulation of RUNX2 expression and activity FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Potential therapeutics for SARS Regulation of NPAS4 gene transcription	Mitochondrial protein import Mitochondrial protein import TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)
Drugs		Flunisolide Diflorasone Alclometasone Medrysone Amcinonide Fluorometholone Megestrol acetate Levonorgestrel Beclomethasone dipropionate Progesterone Spironolactone Betamethasone Desoximetasone Fluticasone propionate Fluocinolone acetonide Ulobetasol Triamcinolone Prednisone Flumethasone Fludrocortisone Norethisterone Hydrocortisone Mometasone Hydrocortamate Mifepristone Clocortolone Flurandrenolide Prednisolone Loteprednol etabonate Rimexolone Methylprednisolone Clobetasol propionate Fluocinonide Prednicarbate Fluoxymesterone Budesonide Dexamethasone Desonide Cortisone acetate Paramethasone Drospirenone Ciclesonide Hexane-1,6-Diol Aldosterone ORG-34517 Difluprednate Ulipristal Fluticasone furoate Tixocortol Difluocortolone Gestrinone Deflazacort Onapristone Cortivazol Clobetasone Fluticasone Mometasone furoate Hydrocortisone aceponate Hydrocortisone acetate Hydrocortisone butyrate Hydrocortisone cypionate Hydrocortisone phosphate Hydrocortisone probutate Hydrocortisone valerate Segesterone acetate Prednisolone phosphate Dexamethasone acetate Betamethasone phosphate Prednisolone acetate	Copper
Diseases		46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency	Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD) Hereditary spastic paraplegia (SPG)
GWAS		Appendicular lean mass ( 33097823) Atrial fibrillation ( 29892015 30061737) Hip circumference adjusted for BMI ( 34021172) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Night sleep phenotypes ( 27126917) PR interval ( 32439900) Spatial processing ( 31596458)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Schizophrenia ( 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		167 interacting genes: ABCC1 ADA AR ARPC5 BAG1 C1orf94 CALM1 CALR CEBPA CEBPB CENPB CHD9 COPS6 CREB1 CREBBP DAP3 DAPK1 DCAF6 DDX54 DNMT3L DOCK3 DTD1 ECD EFHC2 EGFR EP300 EPB41L1 ETS1 ETS2 FAM161B FKBP4 FTH1 FYN GNB1 GNB2 GRIP1 H3C1 HDAC1 HDAC6 HMGB1 HMGB2 HMOX2 HNRNPA1 HNRNPU HSP90AA1 HSP90AB1 HSPA1A HSPD1 IDE IFNGR2 JMJD1C JUN KAT5 KDM5A KPNA2 KRTCAP3 LCK LCOR LPXN LRIF1 MAFF MAPK1 MAPK15 MAPK8 MDM2 MED1 MED14 MED25 MSX2 NCL NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NEDD4L NFKB1 NFKB2 NR0B1 NR0B2 NR1H3 NR2E3 NR2F2 NR2F6 NR3C2 NR4A1 NRIP1 NUP54 ONECUT1 OSGEP PBX1 PELP1 PIAS2 POLR1D POU1F1 POU2F1 POU2F2 PPARGC1A PRDX3 PRKACA PRKDC PRPF6 PSMC3IP PTGES3 PTMS RACK1 RAD54L2 RAD9A RAF1 RAN RARA RBM14 RELA RFPL2 RNF14 RXRB SFN SGTA SHKBP1 SLC25A4 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCD1 SMARCE1 SPIN2A SRA1 SRC STAT3 STAT5A STAT5B STRN3 STUB1 SUMO1 SUMO4 SVIL SYT1 TADA2A TBP TDG TGFB1I1 TMF1 TNS4 TP53 TRIM24 TRIM28 TSG101 TXN UBB UBE2I UBE2L3 UBE3A UBR1 UBR5 UHRF1 USP2 WTIP YWHAH ZBTB16 ZBTB20 ZBTB3 ZBTB9 ZNF496	58 interacting genes: ALDH2 APP BAK1 BRCA1 CA2 CASP3 CASP9 CEP70 CFTR CLEC7A CLU CYSRT1 DHFR DUX4 ERBB2 ERG FAM107A FHIT FNDC3B H2BC21 HSPE1 ITGA3 ITGB1 KRT31 KRT34 KRT40 KRTAP10-3 KRTAP10-8 KRTAP5-9 LINC01554 LRRK2 LZTS2 MAPK6 MCPH1 NOS1AP NOTCH2NLA NR3C1 OGT PDE4B PLCG2 PLG PPP2R1A PPP2R1B PRKACA PRNP PTEN PTPN11 RASA1 RGS20 SAMD3 SUMO2 SUMO4 SUPT6H TLR1 TMCC2 TRIM63 UBASH3A YWHAG
Entrez ID		2908	3329
HPRD ID		00679	00318
Ensembl ID		ENSG00000113580	ENSG00000144381
Uniprot IDs		E5KQF5 E5KQF6 F1D8N4 P04150	A0A024R3X4 P10809
PDB IDs		1M2Z 1NHZ 1P93 3BQD 3CLD 3E7C 3H52 3K22 3K23 4CSJ 4HN5 4HN6 4LSJ 4MDD 4P6W 4P6X 4UDC 4UDD 5CBX 5CBY 5CBZ 5CC1 5E69 5E6A 5E6B 5E6C 5E6D 5EMC 5EMP 5EMQ 5G3J 5G5W 5NFP 5NFT 5UC1 5UC3 5VA0 5VA7 6BQU 6CFN 6DXK 6EL6 6EL7 6EL9 6X6D 6X6E 6YMO 6YO8 6YOS 7KRJ 7KW7 7PRV 7PRW 7PRX 8A9G 8FFV 8FFW 8VKZ	4PJ1 6HT7 6MRC 6MRD 7AZP 7L7S 8G7J 8G7K 8G7L 8G7M 8G7N 8G7O 8U39
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Nucleoplasm Nucleus Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Transcription Coactivator Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Response To Lipid Negative Regulation Of Biosynthetic Process Chromatin Binding Response To Hormone Nuclear Receptor-mediated Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nuclear Receptor Binding Nuclear Glucocorticoid Receptor Binding Intracellular Signal Transduction Transcription Cis-regulatory Region Binding Protein-containing Complex Hormone-mediated Signaling Pathway Transcription Regulator Complex Enzyme Binding Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cellular Response To Hormone Stimulus	Protein-folding Chaperone Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Signaling Cytosol Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Cell Communication Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Signal Transduction Signal Transduction Regulation Of Proteolysis Regulation Of Calcium-mediated Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Calcium-mediated Signaling Negative Regulation Of Cell Adhesion Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Signaling Identical Protein Binding Negative Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-2 Production Protein Heterodimerization Activity Regulation Of Protein Localization Glutamatergic Synapse Response To Stress Regulation Of Cytokine Production Fibroblast Apoptotic Process Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Proteolysis Regulation Of Reactive Oxygen Species Metabolic Process Integrin Alpha3-beta1 Complex Membrane Raft Modulation Of Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Regulation Of Calcium Ion Transmembrane Transport Neuron Projection Organization Regulation Of Programmed Cell Death Response To Yeast Cognition Regulation Of Cellular Localization Keratin Filament Regulation Of Multicellular Organismal Process
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