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NR3C1 and SUMO1
Number of citations of the paper that reports this interaction (PubMedID
12144530
)
39
Data Source:
HPRD
(in vivo)
NR3C1
SUMO1
Description
nuclear receptor subfamily 3 group C member 1
small ubiquitin like modifier 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Centrosome
Spindle
Cytosol
Cytoskeleton
Membrane
Nuclear Speck
Protein-containing Complex
Synapse
XY Body
Nucleus
Nuclear Pore
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Voltage-gated Potassium Channel Complex
Membrane
Nuclear Body
PML Body
Nuclear Speck
Nuclear Membrane
Nuclear Stress Granule
Glutamatergic Synapse
Presynaptic Cytosol
Postsynaptic Cytosol
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
RNA Binding
Nuclear Receptor Activity
Nuclear Glucocorticoid Receptor Activity
Steroid Binding
Protein Binding
Zinc Ion Binding
Lipid Binding
TBP-class Protein Binding
Protein Kinase Binding
Estrogen Response Element Binding
Identical Protein Binding
Sequence-specific DNA Binding
Metal Ion Binding
Hsp90 Protein Binding
Steroid Hormone Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
RNA Binding
Protein Binding
Transcription Factor Binding
Potassium Channel Regulator Activity
Enzyme Binding
Protein Tag Activity
Ubiquitin Protein Ligase Binding
Small Protein Activating Enzyme Binding
Ubiquitin-like Protein Ligase Binding
Transporter Activator Activity
Ubiquitin-specific Protease Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Gluconeogenesis
Chromatin Organization
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Chromosome Segregation
Signal Transduction
Glucocorticoid Metabolic Process
Response To Wounding
Gene Expression
Microglia Differentiation
Adrenal Gland Development
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Regulation Of Glucocorticoid Biosynthetic Process
Nuclear Receptor-mediated Corticosteroid Signaling Pathway
Synaptic Transmission, Glutamatergic
Maternal Behavior
Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Astrocyte Differentiation
Cell Division
Response To Glucocorticoid
Response To Cortisol
Mammary Gland Duct Morphogenesis
Motor Behavior
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Glucocorticoid Stimulus
Cellular Response To Dexamethasone Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Neuroinflammatory Response
Response To Ketone
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Transcription By RNA Polymerase II
DNA Repair
Regulation Of DNA-templated Transcription
Protein Sumoylation
PML Body Organization
Positive Regulation Of Protein-containing Complex Assembly
Regulation Of Protein Stability
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Localization
Cellular Response To Heat
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Action Potential
Negative Regulation Of DNA-templated Transcription
Protein Stabilization
Roof Of Mouth Development
Cellular Response To Cadmium Ion
Regulation Of Cardiac Muscle Cell Contraction
Protein Localization To Nuclear Pore
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Regulation Of Calcium Ion Transmembrane Transport
Pathways
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
SUMOylation of intracellular receptors
PTK6 Expression
Regulation of RUNX2 expression and activity
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Potential therapeutics for SARS
Regulation of NPAS4 gene transcription
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Formation of Incision Complex in GG-NER
Regulation of IFNG signaling
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Postmitotic nuclear pore complex (NPC) reformation
Maturation of nucleoprotein
Maturation of nucleoprotein
SUMOylation of nuclear envelope proteins
PKR-mediated signaling
Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Flunisolide
Diflorasone
Alclometasone
Medrysone
Amcinonide
Fluorometholone
Megestrol acetate
Levonorgestrel
Beclomethasone dipropionate
Progesterone
Spironolactone
Betamethasone
Desoximetasone
Fluticasone propionate
Fluocinolone acetonide
Ulobetasol
Triamcinolone
Prednisone
Flumethasone
Fludrocortisone
Norethisterone
Hydrocortisone
Mometasone
Hydrocortamate
Mifepristone
Clocortolone
Flurandrenolide
Prednisolone
Loteprednol etabonate
Rimexolone
Methylprednisolone
Clobetasol propionate
Fluocinonide
Prednicarbate
Fluoxymesterone
Budesonide
Dexamethasone
Desonide
Cortisone acetate
Paramethasone
Drospirenone
Ciclesonide
Hexane-1,6-Diol
Aldosterone
ORG-34517
Difluprednate
Ulipristal
Fluticasone furoate
Tixocortol
Difluocortolone
Gestrinone
Deflazacort
Onapristone
Cortivazol
Clobetasone
Fluticasone
Mometasone furoate
Hydrocortisone aceponate
Hydrocortisone acetate
Hydrocortisone butyrate
Hydrocortisone cypionate
Hydrocortisone phosphate
Hydrocortisone probutate
Hydrocortisone valerate
Segesterone acetate
Prednisolone phosphate
Dexamethasone acetate
Betamethasone phosphate
Prednisolone acetate
Diseases
46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
GWAS
Appendicular lean mass (
33097823
)
Atrial fibrillation (
29892015
30061737
)
Hip circumference adjusted for BMI (
34021172
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Night sleep phenotypes (
27126917
)
PR interval (
32439900
)
Spatial processing (
31596458
)
Interacting Genes
167 interacting genes:
ABCC1
ADA
AR
ARPC5
BAG1
C1orf94
CALM1
CALR
CEBPA
CEBPB
CENPB
CHD9
COPS6
CREB1
CREBBP
DAP3
DAPK1
DCAF6
DDX54
DNMT3L
DOCK3
DTD1
ECD
EFHC2
EGFR
EP300
EPB41L1
ETS1
ETS2
FAM161B
FKBP4
FTH1
FYN
GNB1
GNB2
GRIP1
H3C1
HDAC1
HDAC6
HMGB1
HMGB2
HMOX2
HNRNPA1
HNRNPU
HSP90AA1
HSP90AB1
HSPA1A
HSPD1
IDE
IFNGR2
JMJD1C
JUN
KAT5
KDM5A
KPNA2
KRTCAP3
LCK
LCOR
LPXN
LRIF1
MAFF
MAPK1
MAPK15
MAPK8
MDM2
MED1
MED14
MED25
MSX2
NCL
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOR1
NCOR2
NEDD4L
NFKB1
NFKB2
NR0B1
NR0B2
NR1H3
NR2E3
NR2F2
NR2F6
NR3C2
NR4A1
NRIP1
NUP54
ONECUT1
OSGEP
PBX1
PELP1
PIAS2
POLR1D
POU1F1
POU2F1
POU2F2
PPARGC1A
PRDX3
PRKACA
PRKDC
PRPF6
PSMC3IP
PTGES3
PTMS
RACK1
RAD54L2
RAD9A
RAF1
RAN
RARA
RBM14
RELA
RFPL2
RNF14
RXRB
SFN
SGTA
SHKBP1
SLC25A4
SMAD3
SMARCA2
SMARCA4
SMARCB1
SMARCC1
SMARCD1
SMARCE1
SPIN2A
SRA1
SRC
STAT3
STAT5A
STAT5B
STRN3
STUB1
SUMO1
SUMO4
SVIL
SYT1
TADA2A
TBP
TDG
TGFB1I1
TMF1
TNS4
TP53
TRIM24
TRIM28
TSG101
TXN
UBB
UBE2I
UBE2L3
UBE3A
UBR1
UBR5
UHRF1
USP2
WTIP
YWHAH
ZBTB16
ZBTB20
ZBTB3
ZBTB9
ZNF496
154 interacting genes:
AR
ARK2N
ARRB2
ATF2
ATXN1
ATXN3
ATXN7
AXIN1
BIRC3
BLM
BRCA1
BTBD3
C11orf65
CANX
CARD9
CASP2
CASP8
CCR2
CDK6
CEBPA
CHAF1A
CHD3
CREBBP
DAXX
DEUP1
DNM1
DNMT3B
DTX2
EDARADD
EGLN3
EIF2AK2
ERCC6
ETV6
FAF1
FAM118B
FAS
FASLG
FBF1
FOS
FOXM1
GMCL1
HDAC4
HDAC9
HGS
HIF1A
HIPK2
HIPK3
HNRNPC
HNRNPK
HSF1
HTT
IKZF3
IRAK1
ISG15
JUN
MAPK1IP1L
MDM2
MEF2A
MITF
MRE11
MRTFA
MSX1
MTOR
MUL1
MYB
NCOA1
NCOA2
NCOA3
NCOR2
NFE2L2
NFKBIA
NIN
NR3C1
NR3C2
PARK7
PAX6
PCNA
PDGFC
PHC1
PIAS1
PIAS2
PIAS3
PIAS4
PKM
PLAGL1
PML
PPM1J
PRKN
PROP1
PSIP1
RAD51
RAD52
RAD54B
RAD54L2
RANBP2
RANGAP1
RHOXF2
RNF111
RNF167
RNF4
RPS3
SALL1
SATB1
SENP1
SENP2
SENP6
SETX
SLC2A1
SMARCAD1
SOX10
SOX2
SOX6
SP100
SP3
SPOP
SREBF1
SREBF2
SUMO1P1
TDG
TDP2
TFCP2
TMIE
TNFRSF1A
TOE1
TOP1
TOP2A
TOP2B
TOPORS
TP53
TP73
TRAF2
TRAF4
TRAF5
TRIM24
TRPS1
TSC22D3
UBA2
UBE2I
USP25
USPL1
WRN
ZBED1
ZBTB16
ZBTB2
ZBTB26
ZBTB6
ZCCHC12
ZCCHC7
ZFP42
ZHX1
ZMYM2
ZMYM3
ZMYM5
ZNF451
Entrez ID
2908
7341
HPRD ID
00679
03554
Ensembl ID
ENSG00000113580
ENSG00000116030
Uniprot IDs
E5KQF5
E5KQF6
F1D8N4
P04150
B8ZZN6
B9A032
P63165
PDB IDs
1M2Z
1NHZ
1P93
3BQD
3CLD
3E7C
3H52
3K22
3K23
4CSJ
4HN5
4HN6
4LSJ
4MDD
4P6W
4P6X
4UDC
4UDD
5CBX
5CBY
5CBZ
5CC1
5E69
5E6A
5E6B
5E6C
5E6D
5EMC
5EMP
5EMQ
5G3J
5G5W
5NFP
5NFT
5UC1
5UC3
5VA0
5VA7
6BQU
6CFN
6DXK
6EL6
6EL7
6EL9
6X6D
6X6E
6YMO
6YO8
6YOS
7KRJ
7KW7
7PRV
7PRW
7PRX
8A9G
8FFV
8FFW
8VKZ
1A5R
1TGZ
1WYW
1Y8R
1Z5S
2ASQ
2BF8
2G4D
2IO2
2IY0
2IY1
2KQS
2LAS
2MW5
2N1A
2N1V
2PE6
2UYZ
2VRR
3KYC
3KYD
3RZW
3UIP
4WJN
4WJO
4WJP
4WJQ
5AEK
5B7A
5ELJ
5GHD
6EOP
6EOT
6J4I
6JXU
6JXV
6K5T
6TRW
6UYO
6UYP
6UYQ
6UYR
6UYS
6UYT
6UYU
6UYV
6UYX
6UYY
6UYZ
6V7P
6V7Q
6V7R
6V7S
6WW3
6XOG
6XOH
6XOI
8DJH
8DJI
8ODR
9B62
Enriched GO Terms of Interacting Partners
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Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Positive Regulation Of Biosynthetic Process
Nucleoplasm
Nucleus
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Chromatin
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Transcription Coactivator Activity
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
DNA Binding
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Metabolic Process
Intracellular Receptor Signaling Pathway
Response To Lipid
Negative Regulation Of Biosynthetic Process
Chromatin Binding
Response To Hormone
Nuclear Receptor-mediated Signaling Pathway
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Nuclear Receptor Binding
Nuclear Glucocorticoid Receptor Binding
Intracellular Signal Transduction
Transcription Cis-regulatory Region Binding
Protein-containing Complex
Hormone-mediated Signaling Pathway
Transcription Regulator Complex
Enzyme Binding
Steroid Hormone Receptor Signaling Pathway
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Cellular Response To Hormone Stimulus
Regulation Of RNA Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Nucleus
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
PML Body
Nucleoplasm
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
DNA Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Protein Sumoylation
Positive Regulation Of DNA-templated Transcription
Cellular Response To Stress
Positive Regulation Of RNA Metabolic Process
Chromatin
Positive Regulation Of Transcription By RNA Polymerase II
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Chromatin Binding
DNA Damage Response
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Macromolecule Metabolic Process
Response To Stress
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Nuclear Body
Protein-containing Complex
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
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