NR3C1 and SLC25A4

Number of citations of the paper that reports this interaction (PMID 12039962)
10

Data Source:
HPRD (in vivo)

		NR3C1	SLC25A4
Gene Name		nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Cytosol Membrane	Nucleus Mitochondrion Mitochondrial Inner Membrane Integral Component Of Plasma Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Glucocorticoid Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Glucocorticoid-activated RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Protein Dimerization Activity Steroid Hormone Binding	Protein Binding Adenine Transmembrane Transporter Activity
	Biological Process	Regulation Of Gluconeogenesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Glucocorticoid Metabolic Process Gene Expression Chromatin Modification Adrenal Gland Development Regulation Of Glucocorticoid Biosynthetic Process Maternal Behavior Glucocorticoid Receptor Signaling Pathway Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Mammary Gland Duct Morphogenesis Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Glucocorticoid Mediated Signaling Pathway	Mitochondrial Genome Maintenance Generation Of Precursor Metabolites And Energy Energy Reserve Metabolic Process Transport Apoptotic Mitochondrial Changes Adenine Transport Viral Process Small Molecule Metabolic Process Regulation Of Insulin Secretion Transmembrane Transport Negative Regulation Of Necroptotic Process
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression	Integration of energy metabolism Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization HIV Infection Regulation of insulin secretion Host Interactions of HIV factors Mitochondrial protein import Interactions of Vpr with host cellular proteins
Drugs		Flunisolide Diflorasone Alclometasone Medrysone Amcinonide Fluorometholone Megestrol Beclometasone dipropionate Betamethasone Desoximetasone Fluticasone Propionate Fluocinolone Acetonide Halobetasol Propionate Triamcinolone Prednisone Flumethasone Pivalate Fludrocortisone Hydrocortisone Mometasone Hydrocortamate Mifepristone Clocortolone Flurandrenolide Prednisolone Loteprednol Rimexolone Methylprednisolone Clobetasol Fluocinonide Prednicarbate Fluoxymesterone Budesonide Dexamethasone Desonide Cortisone acetate Paramethasone Ciclesonide Hexane-1,6-Diol Difluprednate Fluticasone furoate	Adenosine triphosphate Clodronate [3-(Dodecanoylamino)Propyl](Hydroxy)Dimethylammonium Carboxyatractyloside Cardiolipin Di-Stearoyl-3-Sn-Phosphatidylcholine
Diseases
GWAS
Protein-Protein Interactions		135 interactors: ADA AR ARPC5 BAG1 CALM1 CALR CEBPA CEBPB CENPB CHD9 COPS6 CREB1 CREBBP DAP3 DAXX DCAF6 DDX54 ECD ETS1 ETS2 FKBP4 FTH1 FYN GNB1 GNB2 GNB2L1 GRIP1 HDAC6 HMGB1 HMGB2 HMOX2 HNRNPA1 HNRNPU HSP90AA1 HSPA1A HSPD1 IDE IFNGR2 JUN KAT5 KDM5A KPNA2 LCK LRIF1 MAFF MAPK1 MAPK15 MAPK8 MDM2 MED1 MED14 MED25 MSX2 NCL NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NEDD4L NFKB1 NFKB2 NR0B1 NR1H3 NR2E3 NR2F2 NR2F6 NR3C2 NR4A1 NRIP1 ONECUT1 OSGEP PBX1 PELP1 PIAS2 PML POLR1D POU1F1 POU2F1 POU2F2 PPARGC1A PRKACA PRKDC PRPF6 PSMC3IP PTGES3 PTMS RAD54L2 RAD9A RAF1 RAN RARA RBM14 RELA RNF14 RXRB SFN SLC25A4 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCD1 SMARCE1 SRA1 SRC STAT3 STAT5A STAT5B SUMO1 SUMO4 SVIL SYT1 TADA2A TBP TDG TGFB1I1 TMF1 TP53 TRIM24 TRIM28 TSG101 TXN UBB UBE2I UBE2L3 YWHAH ZBTB16 ZBTB20 ZBTB3 ZBTB9 ZNF496	7 interactors: AR BAX NFKBIA NR3C1 PPID PPIF PRKCE
Entrez ID		2908	291
HPRD ID		00679	00058
Ensembl ID		ENSG00000113580	ENSG00000151729
Uniprot IDs		B7Z7I2 E5KQF5 E5KQF6 F1D8N4 P04150	P12235
PDB IDs		1M2Z 1NHZ 1P93 3BQD 3CLD 3E7C 3H52 3K22 3K23 4HN5 4HN6
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Gene Expression RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Cellular Metabolic Process Cellular Response To Hormone Stimulus Biosynthetic Process Regulation Of Cellular Process Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Androgen Receptor Signaling Pathway Response To Steroid Hormone Response To Organic Cyclic Compound Transcription Initiation From RNA Polymerase II Promoter Response To Lipid DNA-templated Transcription, Initiation Cell Differentiation	Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death Regulation Of Apoptotic Process Regulation Of Cell Death Apoptotic Process Programmed Cell Death Regulation Of Cellular Localization Cellular Response To Lipid Cell Death Death Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Transport Regulation Of Signaling Regulation Of Protein Localization Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Response To Lipid Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Organic Substance Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Organic Cyclic Compound Negative Regulation Of Transporter Activity Negative Regulation Of Apoptotic Process Programmed Necrotic Cell Death Negative Regulation Of Programmed Cell Death Necrotic Cell Death Negative Regulation Of Cell Death Negative Regulation Of Transmembrane Transport Positive Regulation Of Mitochondrion Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Cellular Response To UV Cellular Response To Stimulus Mitochondrial Membrane Organization Response To Abiotic Stimulus Negative Regulation Of Transport Intracellular Steroid Hormone Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Organelle Organization Apoptotic Mitochondrial Changes Positive Regulation Of Neuron Death
Tagcloud ?		2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide cdkn1c ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 phosphoinositide propionate reporter rgs2 ru24858 suboptimal tsc22d3 viii	aberrantly af anr atrial autonomic bioinformatics canine copyright dysregulated fgf19 fgf3 fgf4 fibrillation filtering inducibility lentiviruses lncrnas nearby neurogenesis orchestrators pads pipelines prolong reserved rights shorten tcons transcriptomes twofold
Tagcloud (Difference) ?		2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide cdkn1c ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 phosphoinositide propionate reporter rgs2 ru24858 suboptimal tsc22d3 viii	aberrantly af anr atrial autonomic bioinformatics canine copyright dysregulated fgf19 fgf3 fgf4 fibrillation filtering inducibility lentiviruses lncrnas nearby neurogenesis orchestrators pads pipelines prolong reserved rights shorten tcons transcriptomes twofold
Tagcloud (Intersection) ?