NR3C1 and MED25

Number of citations of the paper that reports this interaction (PMID 17641689)
23

Data Source:
BioGRID (two hybrid)

		NR3C1	MED25
Gene Name		nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	mediator complex subunit 25
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Cytosol Membrane	Nucleoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Glucocorticoid Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Glucocorticoid-activated RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Protein Dimerization Activity Steroid Hormone Binding	Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding
	Biological Process	Regulation Of Gluconeogenesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Glucocorticoid Metabolic Process Gene Expression Chromatin Modification Adrenal Gland Development Regulation Of Glucocorticoid Biosynthetic Process Maternal Behavior Glucocorticoid Receptor Signaling Pathway Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Mammary Gland Duct Morphogenesis Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Glucocorticoid Mediated Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Mediator Complex Assembly
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs		Flunisolide Diflorasone Alclometasone Medrysone Amcinonide Fluorometholone Megestrol Beclometasone dipropionate Betamethasone Desoximetasone Fluticasone Propionate Fluocinolone Acetonide Halobetasol Propionate Triamcinolone Prednisone Flumethasone Pivalate Fludrocortisone Hydrocortisone Mometasone Hydrocortamate Mifepristone Clocortolone Flurandrenolide Prednisolone Loteprednol Rimexolone Methylprednisolone Clobetasol Fluocinonide Prednicarbate Fluoxymesterone Budesonide Dexamethasone Desonide Cortisone acetate Paramethasone Ciclesonide Hexane-1,6-Diol Difluprednate Fluticasone furoate
Diseases
GWAS			Blood trace element (Se levels) ( 23720494)
Protein-Protein Interactions		135 interactors: ADA AR ARPC5 BAG1 CALM1 CALR CEBPA CEBPB CENPB CHD9 COPS6 CREB1 CREBBP DAP3 DAXX DCAF6 DDX54 ECD ETS1 ETS2 FKBP4 FTH1 FYN GNB1 GNB2 GNB2L1 GRIP1 HDAC6 HMGB1 HMGB2 HMOX2 HNRNPA1 HNRNPU HSP90AA1 HSPA1A HSPD1 IDE IFNGR2 JUN KAT5 KDM5A KPNA2 LCK LRIF1 MAFF MAPK1 MAPK15 MAPK8 MDM2 MED1 MED14 MED25 MSX2 NCL NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NEDD4L NFKB1 NFKB2 NR0B1 NR1H3 NR2E3 NR2F2 NR2F6 NR3C2 NR4A1 NRIP1 ONECUT1 OSGEP PBX1 PELP1 PIAS2 PML POLR1D POU1F1 POU2F1 POU2F2 PPARGC1A PRKACA PRKDC PRPF6 PSMC3IP PTGES3 PTMS RAD54L2 RAD9A RAF1 RAN RARA RBM14 RELA RNF14 RXRB SFN SLC25A4 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCD1 SMARCE1 SRA1 SRC STAT3 STAT5A STAT5B SUMO1 SUMO4 SVIL SYT1 TADA2A TBP TDG TGFB1I1 TMF1 TP53 TRIM24 TRIM28 TSG101 TXN UBB UBE2I UBE2L3 YWHAH ZBTB16 ZBTB20 ZBTB3 ZBTB9 ZNF496	16 interactors: CDK8 CREBBP CTDP1 ESR1 HCFC1 MED1 MED15 MED4 MED6 MED8 MED9 NR3C1 RARA RXRA SREBF1 THRA
Entrez ID		2908	81857
HPRD ID		00679	14380
Ensembl ID		ENSG00000113580	ENSG00000104973
Uniprot IDs		B7Z7I2 E5KQF5 E5KQF6 F1D8N4 P04150	Q71SY5
PDB IDs		1M2Z 1NHZ 1P93 3BQD 3CLD 3E7C 3H52 3K22 3K23 4HN5 4HN6	2KY6 2L23 2L6U 2XNF
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Gene Expression RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Cellular Metabolic Process Cellular Response To Hormone Stimulus Biosynthetic Process Regulation Of Cellular Process Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Androgen Receptor Signaling Pathway Response To Steroid Hormone Response To Organic Cyclic Compound Transcription Initiation From RNA Polymerase II Promoter Response To Lipid DNA-templated Transcription, Initiation Cell Differentiation	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Metabolic Process Cellular Response To Lipid Steroid Hormone Mediated Signaling Pathway Regulation Of Metabolic Process Response To Steroid Hormone Cellular Response To Hormone Stimulus Cellular Response To Organic Cyclic Compound Negative Regulation Of Transcription From RNA Polymerase II Promoter Steroid Metabolic Process Gland Development Response To Lipid Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Response To Hormone Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide cdkn1c ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 phosphoinositide propionate reporter rgs2 ru24858 suboptimal tsc22d3 viii	allelic appreciated approximate carrying complementing constrained constraint constructs flowering hypomorphic implies interrupted lengths minuscule occupied pft1 phenocopied photoperiod polyglutamine pursuant stark str strs thaliana traits transgene underlies undescribed varying
Tagcloud (Difference) ?		2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide cdkn1c ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 phosphoinositide propionate reporter rgs2 ru24858 suboptimal tsc22d3 viii	allelic appreciated approximate carrying complementing constrained constraint constructs flowering hypomorphic implies interrupted lengths minuscule occupied pft1 phenocopied photoperiod polyglutamine pursuant stark str strs thaliana traits transgene underlies undescribed varying
Tagcloud (Intersection) ?