JAK3 and PTPN6

Number of citations of the paper that reports this interaction (PubMedID 9520455)
30

Data Source:
HPRD (in vitro)

		JAK3	PTPN6
Description		Janus kinase 3	protein tyrosine phosphatase non-receptor type 6
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Endomembrane System Membrane Extrinsic Component Of Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Protein-containing Complex Specific Granule Lumen Alpha-beta T Cell Receptor Complex Extracellular Exosome Tertiary Granule Lumen
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding	Phosphotyrosine Residue Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity SH3 Domain Binding Protein Kinase Binding SH2 Domain Binding Cell Adhesion Molecule Binding Phosphorylation-dependent Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Negative Regulation Of Dendritic Cell Cytokine Production Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Glycoprotein Biosynthetic Process Cytokine-mediated Signaling Pathway Cell Differentiation B Cell Differentiation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Intracellular Signal Transduction Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Apoptotic Process T Cell Homeostasis Innate Immune Response Negative Regulation Of T-helper 1 Cell Differentiation Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Alpha-beta T Cell Activation Negative Regulation Of T Cell Activation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of T Cell Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Response To Interleukin-9 Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of T-helper 17 Cell Lineage Commitment	MAPK Cascade Mitotic Cell Cycle Pattern Recognition Receptor Signaling Pathway Hematopoietic Progenitor Cell Differentiation Neutrophil Activation Involved In Immune Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Protein Dephosphorylation G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Platelet Formation T Cell Costimulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Mast Cell Activation Involved In Immune Response Positive Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Dephosphorylation Intracellular Signal Transduction Megakaryocyte Development T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Regulation Of B Cell Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Innate Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Inflammatory Response To Wounding Negative Regulation Of Inflammatory Response To Wounding CD27 Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Neutrophil Activation Epididymis Development Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Interleukin-7 signaling Interleukin-7 signaling Signaling by ALK RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling Potential therapeutics for SARS	GPVI-mediated activation cascade Regulation of KIT signaling Signaling by ALK PECAM1 interactions Co-inhibition by PD-1 Signal regulatory protein family interactions Platelet sensitization by LDL Interleukin-3, Interleukin-5 and GM-CSF signaling CD22 mediated BCR regulation Neutrophil degranulation Interferon gamma signaling Regulation of IFNG signaling Interleukin-37 signaling Interferon alpha/beta signaling Interleukin receptor SHC signaling Regulation of IFNA/IFNB signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Nuclear events stimulated by ALK signaling in cancer Growth hormone receptor signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Co-inhibition by BTLA
Drugs		2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one R-348 Ruxolitinib Tofacitinib Baricitinib Fostamatinib Abrocitinib Zanubrutinib	Tiludronic acid
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS			Mean corpuscular hemoglobin concentration ( 29403010) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278)
Interacting Genes		43 interacting genes: ALK APOA1 CD247 CD40 CD81 CDK1 CISH CXCR4 ERBB3 FES GTF2B IKBKG IL2RB IL2RG IL4R IL7R INPP5D IRS1 IRS2 JAK1 JAK2 KHDRBS1 KIT LCK LNX1 PIK3R1 PRMT5 PTK2B PTPN2 PTPN6 PTPRC SH2B2 SHB SOCS1 SOCS2 SOCS3 STAM STAM2 STAT3 STAT5A STAT5B UHRF2 VIL1	118 interacting genes: AATK ABL1 ACTN1 ACTN4 BCR BLNK BTLA CAV1 CBL CCDC88A CD22 CD247 CD300LF CD33 CD5 CD72 CD79A CD79B CDK1 CEACAM1 CLEC4A CNKSR1 CSF2RB CTNNB1 CTNND1 CUZD1 CXCR4 DOK1 EGFR EPOR ERBB2 ERBB3 ERBB4 ESR1 FAS FCGR2B FCRL3 FGFR4 FHL3 FLT3 GAB2 GHR GRB2 H2BC3 HOXA10 IFNAR1 IGF1R IL2RB IL4R IL6ST INSR IRS2 IRS4 JAK1 JAK2 JAK3 KDR KHDRBS1 KIR2DL3 KIR2DL5A KIT KLRA1P KLRB1 KLRC1 LAIR1 LAT LCK LCP2 LIFR LILRB2 LILRB4 LMTK2 LYN MPIG6B MS4A2 MYH9 NOS1 OLIG1 PAG1 PDGFRB PECAM1 PIK3R1 PILRA PILRB PLCG2 PRKCA PRKCD PTK2B PTK7 PTPN11 PTPRC ROR1 ROR2 ROS1 SHC1 SIGLEC10 SIGLEC11 SIGLEC12 SIRPA SLAMF6 SNCA SOS1 SPATA2 SRC SSTR2 STAT5B STAT6 SYK TFG TLR10 TMEM62 TNFRSF1A TRAF3 TRAF6 TREML1 TYK2 VAV1 ZAP70
Entrez ID		3718	5777
HPRD ID		02547	01475
Ensembl ID		ENSG00000105639	ENSG00000111679
Uniprot IDs		P52333	P29350 Q53XS4
PDB IDs		1YVJ 3LXK 3LXL 3PJC 3ZC6 3ZEP 4HVD 4HVG 4HVH 4HVI 4I6Q 4QPS 4QT1 4RIO 4V0G 4Z16 5LWM 5LWN 5TOZ 5TTS 5TTU 5TTV 5VO6 5W86 5WFJ 6AAK 6DA4 6DB3 6DB4 6DUD 6GL9 6GLA 6GLB 6HZV 6NY4 7APF 7APG 7C3N 7Q6H 7UYV 8EXM	1FPR 1GWZ 1X6C 2B3O 2RMX 2YU7 3PS5 4GRY 4GRZ 4GS0 4HJP 4HJQ 6SM5 8YHI
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Developmental Process Positive Regulation Of Immune System Process Signal Transduction Regulation Of Immune System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Hemopoiesis Enzyme-linked Receptor Protein Signaling Pathway Lymphocyte Activation Regulation Of Cell Differentiation Positive Regulation Of Cell Activation Regulation Of Cell Development Regulation Of Developmental Process Regulation Of Lymphocyte Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT T Cell Differentiation Growth Hormone Receptor Signaling Pathway Cell Activation Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Lymphocyte Differentiation Leukocyte Activation Cell Surface Receptor Signaling Pathway Via STAT T Cell Activation Lymphocyte Mediated Immunity Regulation Of Immune Response Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Regulation Of Cell-cell Adhesion Mononuclear Cell Differentiation Lymphocyte Differentiation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Differentiation Immune System Process B Cell Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Differentiation Positive Regulation Of Lymphocyte Differentiation Regulation Of Cell Activation Positive Regulation Of Cell Development Leukocyte Mediated Immunity Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Apoptotic Process Leukocyte Differentiation	Cell Surface Receptor Signaling Pathway Signal Transduction Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Regulation Of Immune Response Regulation Of Immune System Process Enzyme-linked Receptor Protein Signaling Pathway Immune System Process Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Immune Response-regulating Signaling Pathway Leukocyte Activation Cell Activation Regulation Of MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation Membrane Lymphocyte Activation Receptor Complex Positive Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Protein Kinase Activity Regulation Of Signal Transduction Regulation Of T Cell Activation Regulation Of Intracellular Signal Transduction Immune Response Positive Regulation Of Intracellular Signal Transduction Adaptive Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Protein Phosphatase Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Regulation Of Multicellular Organismal Process Protein Phosphorylation Regulation Of Leukocyte Proliferation External Side Of Plasma Membrane Fc Receptor Signaling Pathway Kinase Activity Immune Response-activating Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cell Population Proliferation B Cell Activation Mononuclear Cell Differentiation
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