JAK3 and CD40

Number of citations of the paper that reports this interaction (PMID 9133417)
31

Data Source:
HPRD (in vitro)

		JAK3	CD40
Gene Name		Janus kinase 3	CD40 molecule, TNF receptor superfamily member 5
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Endomembrane System Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface CD40 Receptor Complex Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Hormone Receptor Binding	Antigen Binding Signal Transducer Activity Receptor Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Dendritic Cell Cytokine Production Protein Phosphorylation Inflammatory Response Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Tyrosine Phosphorylation Of STAT Protein STAT Protein Import Into Nucleus Cell Migration Peptidyl-tyrosine Phosphorylation B Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Intracellular Signal Transduction Interleukin-4-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process T Cell Homeostasis Innate Immune Response Negative Regulation Of FasL Biosynthetic Process Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of T Cell Activation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of T Cell Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Response To Interleukin-9 Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Positive Regulation Of Protein Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Complex Assembly Cellular Calcium Ion Homeostasis Inflammatory Response Platelet Activation Positive Regulation Of B Cell Proliferation Positive Regulation Of Interleukin-12 Production Positive Regulation Of Rac GTPase Activity B Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Regulation Of Immunoglobulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling Interleukin-7 signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Kawasaki disease ( 22446961 22446962) Multiple sclerosis ( 22190364 19525955 21833088) Rheumatoid arthritis ( 18794853 20453842)
Protein-Protein Interactions		41 interactors: ALK APOA1 CD247 CD40 CD81 CDK1 CXCR4 ERBB3 FES GTF2B IKBKG IL2RB IL2RG IL4R IL7R INPP5D IRS1 IRS2 JAK1 JAK2 KHDRBS1 KIT LCK PIK3R1 PRMT5 PTK2B PTPN2 PTPN6 PTPRC SH2B2 SHB SOCS1 SOCS3 STAM STAM2 STAT3 STAT5A STAT5B TIAF1 UHRF2 VIL1	26 interactors: BIRC2 BIRC3 CAV1 CBL CD40LG FAF1 HSPA4 HSPA8 IL4R JAK3 MAP3K8 MS4A1 NCOA6 NSMAF PIK3R1 RIPK2 SUMO1 TDP2 TRAF1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRAF6 XRCC5 XRCC6
Entrez ID		3718	958
HPRD ID		02547	00178
Ensembl ID		ENSG00000105639	ENSG00000101017
Uniprot IDs		P52333	P25942
PDB IDs		1YVJ 3LXK 3LXL 3PJC 3ZC6 4HVD 4HVG 4HVH 4HVI	1CDF 1CZZ 1D00 1FLL 1LB6 3QD6
Enriched GO Terms of Interacting Partners?		Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Signal Transduction Response To Growth Hormone Cytokine-mediated Signaling Pathway Signaling Cell Communication Immune System Process Defense Response Cellular Response To Organic Substance Regulation Of Cell Activation Cellular Response To Cytokine Stimulus Positive Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Stimulus Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Peptide JAK-STAT Cascade Immune Response Regulation Of Signal Transduction Regulation Of Signaling Response To Organic Substance Response To Cytokine Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation Regulation Of Kinase Activity Response To Hormone Regulation Of Phosphorylation Innate Immune Response Response To Peptide Hormone Immune Response-regulating Signaling Pathway Cellular Response To Hormone Stimulus Cell Proliferation Cellular Response To Organonitrogen Compound Regulation Of JAK-STAT Cascade Response To Peptide Regulation Of Cell Adhesion Regulation Of Phosphorus Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Proliferation	Immune System Process Immune Response Regulation Of Apoptotic Process Apoptotic Process Regulation Of Cell Death Programmed Cell Death Cell Death Death Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Response To Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Signal Transduction Positive Regulation Of Cell-cell Adhesion Regulation Of Immune System Process Defense Response Toll-like Receptor 4 Signaling Pathway Innate Immune Response Response To Stress Regulation Of T Cell Activation Regulation Of Immune Response Positive Regulation Of Cell Activation Positive Regulation Of Immune System Process Toll-like Receptor Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organic Substance Pattern Recognition Receptor Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Intracellular Signal Transduction Innate Immune Response-activating Signal Transduction Regulation Of Innate Immune Response Activation Of Innate Immune Response Regulation Of Cell Adhesion Signaling Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Cell Communication Regulation Of Cell Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Signal Transduction
Tagcloud ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular kappab mediators molecule much mutants necrosis residues strongly tail traf traf2 traf3 traf5 traf6 transduction	adhesion affinity bind cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf traf2 traf3 traf5 traf6 transduction
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf traf2 traf3 traf5 traf6 transduction