JAK3 and UHRF2

Number of citations of the paper that reports this interaction (PMID 21952639)
4

Data Source:
BioGRID (far western blotting)

		JAK3	UHRF2
Gene Name		Janus kinase 3	ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Endomembrane System Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Nucleus Nucleoplasm Nuclear Heterochromatin
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Hormone Receptor Binding	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Histone Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Dendritic Cell Cytokine Production Protein Phosphorylation Inflammatory Response Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Tyrosine Phosphorylation Of STAT Protein STAT Protein Import Into Nucleus Cell Migration Peptidyl-tyrosine Phosphorylation B Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Intracellular Signal Transduction Interleukin-4-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process T Cell Homeostasis Innate Immune Response Negative Regulation Of FasL Biosynthetic Process Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of T Cell Activation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of T Cell Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Response To Interleukin-9 Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Cell Proliferation Protein Ubiquitination Cell Differentiation Regulation Of Cell Cycle Protein Autoubiquitination Positive Regulation Of Cell Cycle Arrest
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling Interleukin-7 signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS			Periodontal microbiota ( 22699663)
Protein-Protein Interactions		41 interactors: ALK APOA1 CD247 CD40 CD81 CDK1 CXCR4 ERBB3 FES GTF2B IKBKG IL2RB IL2RG IL4R IL7R INPP5D IRS1 IRS2 JAK1 JAK2 KHDRBS1 KIT LCK PIK3R1 PRMT5 PTK2B PTPN2 PTPN6 PTPRC SH2B2 SHB SOCS1 SOCS3 STAM STAM2 STAT3 STAT5A STAT5B TIAF1 UHRF2 VIL1	37 interactors: ATXN1 BAX BCAR1 BCL2L1 CCND1 CD27 CDK1 CDK2 CDK4 CDK6 CTNNB1 FYN HDAC1 HIST1H3A JAK3 LCK LYN MCL1 PCNA PCNP PTPRC RAD51 RB1 RBCK1 SKP1 SMAD4 TP53 TRIM27 TRIM8 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2K UBE2W USP7 YY1
Entrez ID		3718	115426
HPRD ID		02547	18257
Ensembl ID		ENSG00000105639	ENSG00000147854
Uniprot IDs		P52333	Q96PU4
PDB IDs		1YVJ 3LXK 3LXL 3PJC 3ZC6 4HVD 4HVG 4HVH 4HVI	1WY8 1Z6U 2E6S 3OLN
Enriched GO Terms of Interacting Partners?		Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Signal Transduction Response To Growth Hormone Cytokine-mediated Signaling Pathway Signaling Cell Communication Immune System Process Defense Response Cellular Response To Organic Substance Regulation Of Cell Activation Cellular Response To Cytokine Stimulus Positive Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Stimulus Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Peptide JAK-STAT Cascade Immune Response Regulation Of Signal Transduction Regulation Of Signaling Response To Organic Substance Response To Cytokine Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation Regulation Of Kinase Activity Response To Hormone Regulation Of Phosphorylation Innate Immune Response Response To Peptide Hormone Immune Response-regulating Signaling Pathway Cellular Response To Hormone Stimulus Cell Proliferation Cellular Response To Organonitrogen Compound Regulation Of JAK-STAT Cascade Response To Peptide Regulation Of Cell Adhesion Regulation Of Phosphorus Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Proliferation	Response To Stress Cellular Response To Stimulus Response To Stimulus Response To Organic Substance Response To Abiotic Stimulus Regulation Of Immune System Process Signaling Immune System Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Signal Transduction Cell Communication Proteasomal Protein Catabolic Process Regulation Of Metabolic Process Cellular Protein Modification Process Cellular Response To DNA Damage Stimulus Regulation Of Cell Proliferation Cellular Response To Stress Regulation Of Cell Death Positive Regulation Of Immune System Process Negative Regulation Of Cellular Metabolic Process Cell Cycle Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Cell Cycle Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Cell Cycle Process Cell Cycle Phase Transition Protein Polyubiquitination Positive Regulation Of Metabolic Process Regulation Of Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Cellular Protein Catabolic Process Regulation Of Cell Cycle Positive Regulation Of Apoptotic Signaling Pathway Mitotic Cell Cycle Positive Regulation Of Apoptotic Process Protein Ubiquitination Positive Regulation Of Programmed Cell Death Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cell Death
Tagcloud ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular kappab mediators molecule much mutants necrosis residues strongly tail traf traf2 traf3 traf5 traf6 transduction	aberrant base ber carcinogenesis confocal dissect endogenous excision finger glycosylase homolog immunoprecipitation interact interacted interacting ip link linkage localized maintenance methylpurine mpg nucleoplasm phd providing repair screened uhrf1
Tagcloud (Difference) ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular kappab mediators molecule much mutants necrosis residues strongly tail traf traf2 traf3 traf5 traf6 transduction	aberrant base ber carcinogenesis confocal dissect endogenous excision finger glycosylase homolog immunoprecipitation interact interacted interacting ip link linkage localized maintenance methylpurine mpg nucleoplasm phd providing repair screened uhrf1
Tagcloud (Intersection) ?