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PTPN6 and KHDRBS1
Number of citations of the paper that reports this interaction (PMID
9045636
)
17
Data Source:
HPRD
(in vitro)
PTPN6
KHDRBS1
Gene Name
protein tyrosine phosphatase, non-receptor type 6
KH domain containing, RNA binding, signal transduction associated 1
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Cytosol
Cell-cell Junction
Membrane
Alpha-beta T Cell Receptor Complex
Extracellular Vesicular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Membrane
Grb2-Sos Complex
Molecular Function
Phosphotyrosine Binding
Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
SH2 Domain Binding
DNA Binding
RNA Binding
SH3/SH2 Adaptor Activity
Protein Binding
Poly(A) Binding
Poly(U) RNA Binding
SH3 Domain Binding
Protein Complex Binding
Identical Protein Binding
Poly(A) RNA Binding
Biological Process
Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Protein Dephosphorylation
Apoptotic Process
G-protein Coupled Receptor Signaling Pathway
Blood Coagulation
Cell Proliferation
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Platelet Formation
T Cell Costimulation
Abortive Mitotic Cell Cycle
Positive Regulation Of Cell Adhesion Mediated By Integrin
Peptidyl-tyrosine Dephosphorylation
Megakaryocyte Development
Negative Regulation Of T Cell Proliferation
Natural Killer Cell Mediated Cytotoxicity
Negative Regulation Of MAP Kinase Activity
Regulation Of B Cell Differentiation
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
B Cell Receptor Signaling Pathway
Negative Regulation Of B Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Receptor Signaling Pathway
Leukocyte Migration
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Regulation Of Type I Interferon-mediated Signaling Pathway
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Transcription, DNA-templated
MRNA Processing
Cell Cycle Arrest
Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Proliferation
Positive Regulation Of Signal Transduction
Regulation Of Protein Stability
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Translational Initiation
Regulation Of RNA Export From Nucleus
Positive Regulation Of RNA Export From Nucleus
Pathways
Costimulation by the CD28 family
Signaling by SCF-KIT
Interferon gamma signaling
Regulation of KIT signaling
Interleukin receptor SHC signaling
Interferon alpha/beta signaling
Regulation of IFNA signaling
Interferon Signaling
Cytokine Signaling in Immune system
Signal regulatory protein (SIRP) family interactions
Cell surface interactions at the vascular wall
PECAM1 interactions
Signaling by Interleukins
Platelet homeostasis
Platelet sensitization by LDL
Interleukin receptor SHC signaling
PD-1 signaling
Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
Regulation of IFNG signaling
Growth hormone receptor signaling
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
98 interactors:
ABL1
ACTN1
ACTN4
BCR
BLNK
BTLA
C6orf25
CAV1
CBL
CD22
CD247
CD300LF
CD33
CD5
CD72
CD79A
CD79B
CEACAM1
CLEC4A
CSF2RB
CTNNB1
CTNND1
CUZD1
CXCR4
DOK1
EGFR
EPOR
ESR1
FAS
FCGR2B
FCRL3
FHL3
FLT3
GAB2
GHR
GRB2
HOXA10
IFNAR1
IL2RB
IL4R
IL6ST
INSR
IRS2
IRS4
JAK1
JAK2
JAK3
KDR
KHDRBS1
KIR2DL3
KIR2DL5A
KIT
KLRAP1
KLRB1
KLRC1
LAIR1
LCK
LCP2
LIFR
LILRB2
LILRB4
LYN
MS4A2
MYH9
NOS1
PAG1
PECAM1
PIK3R1
PILRA
PILRB
PRKCA
PRKCD
PTK2B
PTPN11
PTPRC
ROS1
SHC1
SIGLEC10
SIGLEC11
SIGLEC12
SIRPA
SLAMF6
SOS1
SPATA2
SRC
SSTR2
STAT5B
STAT6
SYK
TFG
TLR10
TMEM62
TNFRSF1A
TRAF6
TREML1
TYK2
VAV1
ZAP70
109 interactors:
ABI2
ACTB
AGO1
AHI1
AMPH
APBB1
ARHGEF4
ARHGEF9
AZIN1
BAIAP2L1
BTK
BZRAP1
CBL
CD2AP
CDK1
CIRBP
CREB3L3
CREBBP
CRK
CRKL
CSK
DDX5
DHX9
DLG1
DLG2
DLG3
DLG4
DNMBP
DOCK2
DOCK3
EFEMP1
EMG1
FGR
FNBP4
FRK
FYN
GAS7
GPHN
GRAP
GRAP2
GRB2
HCK
HNRNPK
INSR
ITK
ITSN1
ITSN2
JAK3
KHDRBS3
LCK
LYN
MAPK1
MIA2
MPP6
MYO1C
MYO7A
NCF1
NCK1
NCK2
NCKIPSD
NPHP1
OSTF1
PACSIN1
PIK3R1
PIK3R3
PLCG1
PLCG2
POT1
PPP1R13B
PRMT1
PSTPIP1
PTBP2
PTK6
PTPN6
RALY
RAPSN
RASA1
RBFOX2
RBM7
RBMX
RUSC2
SASH1
SCG5
SH3PXD2A
SH3YL1
SKAP2
SMAD2
SMARCA2
SNX30
SNX9
SORBS1
SPATA13
SRC
SSFA2
STAT3
STUB1
TBL1X
TJP1
TNFSF11
TUBB3
U2AF2
UBA52
UBASH3B
VAV1
WBP4
YES1
YTHDC1
ZBTB7A
ZDHHC6
Entrez ID
5777
10657
HPRD ID
01475
03926
Ensembl ID
ENSG00000111679
ENSG00000121774
Uniprot IDs
P29350
Q53XS4
Q07666
PDB IDs
1FPR
1GWZ
1X6C
2B3O
2RMX
2YU7
3PS5
4GRY
4GRZ
4GS0
4HJP
4HJQ
2XA6
3QHE
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Immune System Process
Immune System Process
Signaling
Enzyme Linked Receptor Protein Signaling Pathway
Cell Communication
Regulation Of Immune Response
Cellular Response To Stimulus
Regulation Of Cell Activation
Cell Activation
Response To Stimulus
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Activation
Positive Regulation Of Signal Transduction
Immune Response
Immune Response-regulating Signaling Pathway
Defense Response
Regulation Of Cell-cell Adhesion
Cellular Response To Organic Substance
Regulation Of Lymphocyte Activation
Innate Immune Response
Positive Regulation Of Immune System Process
Response To Organic Substance
Cell Migration
Peptidyl-tyrosine Autophosphorylation
Positive Regulation Of Cell Adhesion
Blood Coagulation
Hemostasis
Cell Motility
Regulation Of Cell Adhesion
Positive Regulation Of T Cell Activation
Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Peptidyl-tyrosine Phosphorylation
Regulation Of Signal Transduction
Cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of Body Fluid Levels
Intracellular Signal Transduction
Leukocyte Activation
Leukocyte Differentiation
Leukocyte Migration
Fc Receptor Signaling Pathway
Regulation Of Signaling
Response To Cytokine
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Response To Stress
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Fc Receptor Signaling Pathway
Signaling
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cell Communication
Peptidyl-tyrosine Autophosphorylation
Innate Immune Response
Signal Transduction
Immune Response-regulating Signaling Pathway
Immune Response
Endocytosis
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Locomotion
Movement Of Cell Or Subcellular Component
Cellular Response To Stimulus
Positive Regulation Of Metabolic Process
Cell Surface Receptor Signaling Pathway
Defense Response
Positive Regulation Of Immune Response
Regulation Of Immune System Process
Cellular Response To Peptide Hormone Stimulus
Neurotrophin TRK Receptor Signaling Pathway
Phagocytosis
Cellular Response To Peptide
Positive Regulation Of Immune System Process
Neurotrophin Signaling Pathway
Positive Regulation Of Signal Transduction
Cellular Response To Growth Factor Stimulus
Regulation Of Immune Response
Epidermal Growth Factor Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Response To Growth Factor
Antigen Receptor-mediated Signaling Pathway
Cell Differentiation
Regulation Of Catalytic Activity
Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Regulation Of Cellular Component Organization
Immune System Process
Response To Stimulus
Regulation Of Signaling
Cell Projection Organization
Intracellular Signal Transduction
Cellular Response To Organic Substance
Regulation Of Metabolic Process
Tagcloud
?
a2
ag
cd45
chimera
chimeras
chimeric
coupling
diminished
enzymatic
fails
hcp
hemopoietic
initiated
inositol
j45
jurkat
ligation
lymphoid
phosphatase
phospholipase
phosphotyrosine
ptp1c
rescue
shp
shptp
surprisingly
tcr
transduction
unlike
Tagcloud (Difference)
?
a2
ag
cd45
chimera
chimeras
chimeric
coupling
diminished
enzymatic
fails
hcp
hemopoietic
initiated
inositol
j45
jurkat
ligation
lymphoid
phosphatase
phospholipase
phosphotyrosine
ptp1c
rescue
shp
shptp
surprisingly
tcr
transduction
unlike
Tagcloud (Intersection)
?