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JAK3 and ALK
Number of citations of the paper that reports this interaction (PubMedID
11850821
)
0
Data Source:
HPRD
(in vivo)
JAK3
ALK
Description
Janus kinase 3
ALK receptor tyrosine kinase
Image
GO Annotations
Cellular Component
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Endomembrane System
Membrane
Extrinsic Component Of Plasma Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Plasma Membrane
Membrane
Protein-containing Complex
Receptor Complex
Extracellular Exosome
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Growth Hormone Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Phosphatase Binding
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Heparin Binding
Kinase Activity
Transferase Activity
Receptor Signaling Protein Tyrosine Kinase Activator Activity
Identical Protein Binding
Biological Process
Adaptive Immune Response
Immune System Process
Negative Regulation Of Dendritic Cell Cytokine Production
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Glycoprotein Biosynthetic Process
Cytokine-mediated Signaling Pathway
Cell Differentiation
B Cell Differentiation
Negative Regulation Of Interleukin-10 Production
Negative Regulation Of Interleukin-12 Production
Intracellular Signal Transduction
Interleukin-15-mediated Signaling Pathway
Interleukin-4-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Regulation Of Apoptotic Process
T Cell Homeostasis
Innate Immune Response
Negative Regulation Of T-helper 1 Cell Differentiation
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Regulation Of Alpha-beta T Cell Activation
Negative Regulation Of T Cell Activation
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Regulation Of T Cell Apoptotic Process
Negative Regulation Of Thymocyte Apoptotic Process
Response To Interleukin-2
Response To Interleukin-4
Response To Interleukin-15
Response To Interleukin-9
Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of T-helper 17 Cell Lineage Commitment
Response To Stress
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Nervous System Development
Brain Development
Phosphorylation
Hippocampus Development
Adult Behavior
Swimming Behavior
Peptidyl-tyrosine Autophosphorylation
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Regulation Of Neuron Differentiation
Protein Autophosphorylation
Neuron Development
Negative Regulation Of Lipid Catabolic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Dopamine Receptor Signaling Pathway
Regulation Of Primary Metabolic Process
Response To Environmental Enrichment
Energy Homeostasis
Positive Regulation Of Dendrite Development
Pathways
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by ALK
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Interleukin receptor SHC signaling
Potential therapeutics for SARS
Signaling by ALK
Signaling by ALK
ALK mutants bind TKIs
ASP-3026-resistant ALK mutants
NVP-TAE684-resistant ALK mutants
alectinib-resistant ALK mutants
brigatinib-resistant ALK mutants
ceritinib-resistant ALK mutants
crizotinib-resistant ALK mutants
lorlatinib-resistant ALK mutants
Signaling by ALK fusions and activated point mutants
MDK and PTN in ALK signaling
MDK and PTN in ALK signaling
Drugs
2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
R-348
Ruxolitinib
Tofacitinib
Baricitinib
Fostamatinib
Abrocitinib
Zanubrutinib
ATP
Crizotinib
Ceritinib
Alectinib
Fostamatinib
Lorlatinib
Gilteritinib
Brigatinib
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
Non-small cell lung cancer
GWAS
Adiponectin levels (BMI-adjusted) (
26299439
)
Body mass index (
25673413
)
Body size at age 10 (
32376654
)
Carbamazepine-induced reaction with eosinophilia and systemic symptoms (
31066027
)
Carbamazepine-induced serious cutaneous adverse reaction (
31066027
)
Dentures (
31235808
)
Gestational age at birth (child effect) (
31194736
)
Glucose homeostasis traits (
25524916
)
Low density lipoprotein cholesterol levels (
33339817
)
Number of decayed, missing and filled tooth surfaces or use of dentures (
31235808
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Simvastatin-induced myopathy (
31220337
)
Spontaneous coronary artery dissection (
32887874
)
Systolic blood pressure (
26969751
)
Total cholesterol levels (
33339817
)
Interacting Genes
43 interacting genes:
ALK
APOA1
CD247
CD40
CD81
CDK1
CISH
CXCR4
ERBB3
FES
GTF2B
IKBKG
IL2RB
IL2RG
IL4R
IL7R
INPP5D
IRS1
IRS2
JAK1
JAK2
KHDRBS1
KIT
LCK
LNX1
PIK3R1
PRMT5
PTK2B
PTPN2
PTPN6
PTPRC
SH2B2
SHB
SOCS1
SOCS2
SOCS3
STAM
STAM2
STAT3
STAT5A
STAT5B
UHRF2
VIL1
19 interacting genes:
APBB1
DUSP19
ERBB2
HES1
IKBKG
IRS1
JAK3
MDK
NPM1
PIK3R1
PLCG1
PPM1A
PTN
PTPN11
PTPRZ1
SHC1
SHC3
TNFRSF8
ZC3HC1
Entrez ID
3718
238
HPRD ID
02547
00104
Ensembl ID
ENSG00000105639
ENSG00000171094
Uniprot IDs
P52333
A0A0K2YUJ3
B6D4Y2
Q9UM73
PDB IDs
1YVJ
3LXK
3LXL
3PJC
3ZC6
3ZEP
4HVD
4HVG
4HVH
4HVI
4I6Q
4QPS
4QT1
4RIO
4V0G
4Z16
5LWM
5LWN
5TOZ
5TTS
5TTU
5TTV
5VO6
5W86
5WFJ
6AAK
6DA4
6DB3
6DB4
6DUD
6GL9
6GLA
6GLB
6HZV
6NY4
7APF
7APG
7C3N
7Q6H
7UYV
8EXM
2KUP
2KUQ
2XB7
2XBA
2XP2
2YFX
2YHV
2YJR
2YJS
2YS5
2YT2
3AOX
3L9P
3LCS
3LCT
4ANL
4ANQ
4ANS
4CCB
4CCU
4CD0
4CLI
4CLJ
4CMO
4CMT
4CMU
4CNH
4CTB
4CTC
4DCE
4FNW
4FNX
4FNY
4FNZ
4FOB
4FOC
4FOD
4JOA
4MKC
4TT7
4Z55
5A9U
5AA8
5AA9
5AAA
5AAB
5AAC
5FTO
5FTQ
5IMX
5IUG
5IUH
5IUI
5KZ0
5VZ5
6AT9
6CDT
6E0R
6EBW
6EDL
6MX8
7BTT
7JY4
7JYR
7JYS
7JYT
7LRZ
7LS0
7MZW
7MZY
7N00
7NWZ
7NX3
7NX4
7R7K
7R7R
8ARJ
9G5I
9GBE
Enriched GO Terms of Interacting Partners
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Cell Surface Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Positive Regulation Of Developmental Process
Positive Regulation Of Immune System Process
Signal Transduction
Regulation Of Immune System Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cell Adhesion
Positive Regulation Of Lymphocyte Activation
Regulation Of Hemopoiesis
Enzyme-linked Receptor Protein Signaling Pathway
Lymphocyte Activation
Regulation Of Cell Differentiation
Positive Regulation Of Cell Activation
Regulation Of Cell Development
Regulation Of Developmental Process
Regulation Of Lymphocyte Activation
Cell Surface Receptor Signaling Pathway Via JAK-STAT
T Cell Differentiation
Growth Hormone Receptor Signaling Pathway
Cell Activation
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Regulation Of Lymphocyte Differentiation
Leukocyte Activation
Cell Surface Receptor Signaling Pathway Via STAT
T Cell Activation
Lymphocyte Mediated Immunity
Regulation Of Immune Response
Regulation Of Multicellular Organismal Development
Positive Regulation Of Cell Adhesion
Regulation Of Programmed Cell Death
Regulation Of Multicellular Organismal Process
Regulation Of Cell-cell Adhesion
Mononuclear Cell Differentiation
Lymphocyte Differentiation
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cell Differentiation
Immune System Process
B Cell Activation
Positive Regulation Of Cell-cell Adhesion
Positive Regulation Of T Cell Activation
Positive Regulation Of Leukocyte Differentiation
Positive Regulation Of Lymphocyte Differentiation
Regulation Of Cell Activation
Positive Regulation Of Cell Development
Leukocyte Mediated Immunity
Positive Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Apoptotic Process
Leukocyte Differentiation
Regulation Of Apoptotic Process
Phosphotyrosine Residue Binding
Regulation Of Programmed Cell Death
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Insulin Receptor Binding
Epidermal Growth Factor Receptor Signaling Pathway
Neurotrophin TRKA Receptor Binding
Negative Regulation Of Apoptotic Process
ERBB Signaling Pathway
Negative Regulation Of Programmed Cell Death
Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Development
Signal Transduction
Positive Regulation Of Gene Expression
Positive Regulation Of Glial Cell Differentiation
Regulation Of Oligodendrocyte Differentiation
Negative Regulation Of Cell Adhesion
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Hemopoiesis
Negative Regulation Of T Cell Differentiation
Insulin-like Growth Factor Receptor Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Lymphocyte Differentiation
Negative Regulation Of T Cell Activation
Receptor Tyrosine Kinase Binding
Leukocyte Activation
Positive Regulation Of Gliogenesis
Intracellular Signal Transduction
Positive Regulation Of Vascular Endothelial Cell Proliferation
Regulation Of Glial Cell Differentiation
Positive Regulation Of Oligodendrocyte Differentiation
Positive Regulation Of Immune System Process
Leukocyte Activation Involved In Immune Response
Negative Regulation Of Leukocyte Cell-cell Adhesion
Cell Activation Involved In Immune Response
Cellular Response To Growth Factor Stimulus
Regulation Of Immune System Process
Negative Regulation Of Lymphocyte Activation
Lymphocyte Activation
Cell Activation
Response To Growth Factor
Negative Regulation Of Cell Differentiation
Regulation Of Multicellular Organismal Development
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Leukocyte Activation
Insulin-like Growth Factor Receptor Signaling Pathway
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