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JAK3 and KIT
Number of citations of the paper that reports this interaction (PubMedID
17554063
)
52
Data Source:
BioGRID
(enzymatic study)
JAK3
KIT
Description
Janus kinase 3
KIT proto-oncogene, receptor tyrosine kinase
Image
GO Annotations
Cellular Component
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Endomembrane System
Membrane
Extrinsic Component Of Plasma Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Fibrillar Center
Acrosomal Vesicle
Extracellular Space
Cytoplasm
Plasma Membrane
Cell-cell Junction
External Side Of Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Cell Surface
Membrane
Receptor Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Growth Hormone Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Phosphatase Binding
Nucleotide Binding
Protease Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Stem Cell Factor Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Growth Factor Binding
Cytokine Binding
SH2 Domain Binding
Protein Homodimerization Activity
Metal Ion Binding
Biological Process
Adaptive Immune Response
Immune System Process
Negative Regulation Of Dendritic Cell Cytokine Production
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Glycoprotein Biosynthetic Process
Cytokine-mediated Signaling Pathway
Cell Differentiation
B Cell Differentiation
Negative Regulation Of Interleukin-10 Production
Negative Regulation Of Interleukin-12 Production
Intracellular Signal Transduction
Interleukin-15-mediated Signaling Pathway
Interleukin-4-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Regulation Of Apoptotic Process
T Cell Homeostasis
Innate Immune Response
Negative Regulation Of T-helper 1 Cell Differentiation
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Regulation Of Alpha-beta T Cell Activation
Negative Regulation Of T Cell Activation
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Regulation Of T Cell Apoptotic Process
Negative Regulation Of Thymocyte Apoptotic Process
Response To Interleukin-2
Response To Interleukin-4
Response To Interleukin-15
Response To Interleukin-9
Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of T-helper 17 Cell Lineage Commitment
Ovarian Follicle Development
Hematopoietic Progenitor Cell Differentiation
Myeloid Progenitor Cell Differentiation
Lymphoid Progenitor Cell Differentiation
Immature B Cell Differentiation
Mast Cell Chemotaxis
Positive Regulation Of Cytokine Production Involved In Immune Response
Positive Regulation Of Dendritic Cell Cytokine Production
Glycosphingolipid Metabolic Process
Chemotaxis
Inflammatory Response
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Spermatogenesis
Spermatid Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Germ Cell Migration
Regulation Of Cell Shape
Gonad Development
Visual Learning
Male Gonad Development
Response To Radiation
Positive Regulation Of Gene Expression
Programmed Cell Death
Cell Migration
Cytokine-mediated Signaling Pathway
Stem Cell Population Maintenance
Lamellipodium Assembly
Actin Cytoskeleton Organization
Hemopoiesis
B Cell Differentiation
T Cell Differentiation
Erythrocyte Differentiation
Melanocyte Differentiation
Positive Regulation Of Cell Migration
Positive Regulation Of Pseudopodium Assembly
Positive Regulation Of Mast Cell Cytokine Production
Somatic Stem Cell Population Maintenance
Embryonic Hemopoiesis
Ectopic Germ Cell Programmed Cell Death
Intracellular Signal Transduction
Hematopoietic Stem Cell Migration
Megakaryocyte Development
Fc Receptor Signaling Pathway
Kit Signaling Pathway
Erythropoietin-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Programmed Cell Death
Mast Cell Degranulation
Positive Regulation Of MAPK Cascade
Pigmentation
Tongue Development
Leukocyte Activation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Response To Cadmium Ion
Protein Autophosphorylation
Developmental Pigmentation
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Digestive Tract Development
Stem Cell Differentiation
Epithelial Cell Proliferation
Regulation Of Developmental Process
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound
Positive Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Developmental Process
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cell Chemotaxis
Mast Cell Differentiation
Mast Cell Proliferation
Positive Regulation Of Mast Cell Proliferation
Melanocyte Migration
Melanocyte Adhesion
Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction
Regulation Of Bile Acid Metabolic Process
Positive Regulation Of Colon Smooth Muscle Contraction
Positive Regulation Of Small Intestine Smooth Muscle Contraction
Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Negative Regulation Of Reproductive Process
Pathways
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by ALK
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Interleukin receptor SHC signaling
Potential therapeutics for SARS
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Regulation of KIT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Dasatinib-resistant KIT mutants
Imatinib-resistant KIT mutants
KIT mutants bind TKIs
Masitinib-resistant KIT mutants
Nilotinib-resistant KIT mutants
Regorafenib-resistant KIT mutants
Signaling by kinase domain mutants of KIT
Sunitinib-resistant KIT mutants
Signaling by juxtamembrane domain KIT mutants
Sorafenib-resistant KIT mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by extracellular domain mutants of KIT
Transcriptional and post-translational regulation of MITF-M expression and activity
Developmental Lineage of Mammary Gland Luminal Epithelial Cells
Developmental Lineage of Mammary Gland Alveolar Cells
Drugs
2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
R-348
Ruxolitinib
Tofacitinib
Baricitinib
Fostamatinib
Abrocitinib
Zanubrutinib
Sorafenib
Imatinib
Dasatinib
Sunitinib
Phosphonotyrosine
Nilotinib
XL820
OSI-930
Linifanib
Pazopanib
Midostaurin
Regorafenib
Ponatinib
Lenvatinib
Ancestim
Tivozanib
Fostamatinib
Erdafitinib
Amuvatinib
Pexidartinib
Ripretinib
Avapritinib
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
Acute myeloid leukemia (AML)
Piebaldism
GWAS
Adult body size (
32376654
)
Anorexia nervosa or obsessive-compulsive disorder (
30087453
)
Apolipoprotein A1 levels (
32203549
)
Bipolar disorder (
19416921
)
Breastfeeding duration (
25475840
)
Cadmium levels (
26025379
)
HDL cholesterol levels (
32203549
)
Hematocrit (
28017375
29403010
)
Hemoglobin (
29403010
)
Hemoglobin levels (
28017375
)
High density lipoprotein cholesterol levels (
31928498
)
Mean corpuscular hemoglobin (
28017375
29403010
28453575
)
Mean corpuscular volume (
28453575
28017375
20139978
29403010
19862010
)
Neutrophil percentage of white cells (
32888494
)
Platelet count (
29403010
)
Red blood cell count (
29403010
28453575
28017375
)
Red blood cell traits (
23222517
)
Schizophrenia (
26198764
)
Serum VEGFR2 concentration (
25411163
)
Systemic lupus erythematosus (
29494758
)
Triglyceride levels (
31928498
32203549
)
Interacting Genes
43 interacting genes:
ALK
APOA1
CD247
CD40
CD81
CDK1
CISH
CXCR4
ERBB3
FES
GTF2B
IKBKG
IL2RB
IL2RG
IL4R
IL7R
INPP5D
IRS1
IRS2
JAK1
JAK2
KHDRBS1
KIT
LCK
LNX1
PIK3R1
PRMT5
PTK2B
PTPN2
PTPN6
PTPRC
SH2B2
SHB
SOCS1
SOCS2
SOCS3
STAM
STAM2
STAT3
STAT5A
STAT5B
UHRF2
VIL1
92 interacting genes:
ABL1
ABL2
BCAR3
BLK
BLNK
BTK
CBL
CBLB
CD81
CD9
CISH
CLTC
CRK
CRKL
CSF1R
CSF2RA
CSF2RB
DOK1
EPOR
FES
FGR
FYN
GRAP
GRAP2
GRB10
GRB2
GRB7
HCK
HSH2D
IL7R
ILKAP
INPP5D
JAK2
JAK3
KITLG
LCK
LYN
MATK
MPDZ
NCK1
NCK2
PIK3CG
PIK3R1
PIK3R2
PIK3R3
PLCE1
PLCG1
PLCG2
PRKCA
PRKCB
PTK6
PTPN11
PTPN20
PTPN6
PTPRO
PTPRU
RASA1
SH2B2
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3C
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SLA2
SOCS1
SOCS2
SOCS3
SOCS5
SOCS6
SPRED1
SPRED2
SRC
STAP1
STAT1
STAT5A
STAT5B
STYX
SYK
TEC
TNS1
TNS2
TNS3
TXK
VAV3
YES1
ZAP70
Entrez ID
3718
3815
HPRD ID
02547
01287
Ensembl ID
ENSG00000105639
ENSG00000157404
Uniprot IDs
P52333
A0A0U2N547
A0A8I5KQZ6
A0A8I5KS03
A0A8I5QKL5
A0A8I5QKP7
A0A8J8Z860
P10721
PDB IDs
1YVJ
3LXK
3LXL
3PJC
3ZC6
3ZEP
4HVD
4HVG
4HVH
4HVI
4I6Q
4QPS
4QT1
4RIO
4V0G
4Z16
5LWM
5LWN
5TOZ
5TTS
5TTU
5TTV
5VO6
5W86
5WFJ
6AAK
6DA4
6DB3
6DB4
6DUD
6GL9
6GLA
6GLB
6HZV
6NY4
7APF
7APG
7C3N
7Q6H
7UYV
8EXM
1PKG
1T45
1T46
2E9W
2EC8
2IUH
2VIF
3G0E
3G0F
4HVS
4K94
4K9E
4PGZ
4U0I
6GQJ
6GQK
6GQL
6GQM
6HH1
6ITT
6ITV
6KLA
6MOB
6XV9
6XVA
6XVB
7KHG
7KHJ
7KHK
7ZW8
7ZY6
8DFM
8DFP
8DFQ
8PQ9
8PQA
8PQB
8PQC
8PQD
8PQE
8PQF
8PQG
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Positive Regulation Of Developmental Process
Positive Regulation Of Immune System Process
Signal Transduction
Regulation Of Immune System Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cell Adhesion
Positive Regulation Of Lymphocyte Activation
Regulation Of Hemopoiesis
Enzyme-linked Receptor Protein Signaling Pathway
Lymphocyte Activation
Regulation Of Cell Differentiation
Positive Regulation Of Cell Activation
Regulation Of Cell Development
Regulation Of Developmental Process
Regulation Of Lymphocyte Activation
Cell Surface Receptor Signaling Pathway Via JAK-STAT
T Cell Differentiation
Growth Hormone Receptor Signaling Pathway
Cell Activation
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Regulation Of Lymphocyte Differentiation
Leukocyte Activation
Cell Surface Receptor Signaling Pathway Via STAT
T Cell Activation
Lymphocyte Mediated Immunity
Regulation Of Immune Response
Regulation Of Multicellular Organismal Development
Positive Regulation Of Cell Adhesion
Regulation Of Programmed Cell Death
Regulation Of Multicellular Organismal Process
Regulation Of Cell-cell Adhesion
Mononuclear Cell Differentiation
Lymphocyte Differentiation
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cell Differentiation
Immune System Process
B Cell Activation
Positive Regulation Of Cell-cell Adhesion
Positive Regulation Of T Cell Activation
Positive Regulation Of Leukocyte Differentiation
Positive Regulation Of Lymphocyte Differentiation
Regulation Of Cell Activation
Positive Regulation Of Cell Development
Leukocyte Mediated Immunity
Positive Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Apoptotic Process
Leukocyte Differentiation
Phosphotyrosine Residue Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Immune System Process
Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Antigen Receptor-mediated Signaling Pathway
Regulation Of Cell Adhesion
Regulation Of Immune System Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Protein Tyrosine Kinase Activity
Regulation Of Immune Response
Positive Regulation Of Immune Response
Regulation Of Cell Activation
Cell Activation
Leukocyte Activation
Regulation Of Signal Transduction
Immune System Process
Intracellular Signal Transduction
Immune Response-activating Signaling Pathway
Cytosol
Lymphocyte Activation
Positive Regulation Of Cell Adhesion
Regulation Of Cell-cell Adhesion
Immune Response-regulating Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Activation Of Immune Response
Regulation Of Lymphocyte Activation
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Cell Activation
Positive Regulation Of T Cell Activation
Regulation Of Leukocyte Cell-cell Adhesion
Immune Effector Process
Regulation Of T Cell Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Cytokine-mediated Signaling Pathway
Positive Regulation Of Cell-cell Adhesion
B Cell Receptor Signaling Pathway
Plasma Membrane
Receptor Tyrosine Kinase Binding
Negative Regulation Of Immune System Process
T Cell Activation
Protein Phosphorylation
Fc Receptor Signaling Pathway
ERBB Signaling Pathway
Phosphorylation
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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