JAK3 and CISH

Number of citations of the paper that reports this interaction (PubMedID 34989544)
0

Data Source:
BioGRID (unspecified method)

		JAK3	CISH
Description		Janus kinase 3	cytokine inducible SH2 containing protein
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Endomembrane System Membrane Extrinsic Component Of Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding	Cytokine Receptor Binding Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Negative Regulation Of Dendritic Cell Cytokine Production Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Glycoprotein Biosynthetic Process Cytokine-mediated Signaling Pathway Cell Differentiation B Cell Differentiation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Intracellular Signal Transduction Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Apoptotic Process T Cell Homeostasis Innate Immune Response Negative Regulation Of T-helper 1 Cell Differentiation Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Alpha-beta T Cell Activation Negative Regulation Of T Cell Activation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of T Cell Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Response To Interleukin-9 Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of T-helper 17 Cell Lineage Commitment	Regulation Of Cell Growth Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Pathways		Interleukin-7 signaling Interleukin-7 signaling Signaling by ALK RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling Potential therapeutics for SARS	Interleukin-7 signaling Neddylation Growth hormone receptor signaling
Drugs		2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one R-348 Ruxolitinib Tofacitinib Baricitinib Fostamatinib Abrocitinib Zanubrutinib
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cortical surface area (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		43 interacting genes: ALK APOA1 CD247 CD40 CD81 CDK1 CISH CXCR4 ERBB3 FES GTF2B IKBKG IL2RB IL2RG IL4R IL7R INPP5D IRS1 IRS2 JAK1 JAK2 KHDRBS1 KIT LCK LNX1 PIK3R1 PRMT5 PTK2B PTPN2 PTPN6 PTPRC SH2B2 SHB SOCS1 SOCS2 SOCS3 STAM STAM2 STAT3 STAT5A STAT5B UHRF2 VIL1	20 interacting genes: CSF2RB CSF3R EPOR ERBB2 ETV5 GHR HSPA6 IL2RB IL3RA JAK1 JAK2 JAK3 KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2
Entrez ID		3718	1154
HPRD ID		02547	03897
Ensembl ID		ENSG00000105639	ENSG00000114737
Uniprot IDs		P52333	Q9NSE2
PDB IDs		1YVJ 3LXK 3LXL 3PJC 3ZC6 3ZEP 4HVD 4HVG 4HVH 4HVI 4I6Q 4QPS 4QT1 4RIO 4V0G 4Z16 5LWM 5LWN 5TOZ 5TTS 5TTU 5TTV 5VO6 5W86 5WFJ 6AAK 6DA4 6DB3 6DB4 6DUD 6GL9 6GLA 6GLB 6HZV 6NY4 7APF 7APG 7C3N 7Q6H 7UYV 8EXM
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Developmental Process Positive Regulation Of Immune System Process Signal Transduction Regulation Of Immune System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Hemopoiesis Enzyme-linked Receptor Protein Signaling Pathway Lymphocyte Activation Regulation Of Cell Differentiation Positive Regulation Of Cell Activation Regulation Of Cell Development Regulation Of Developmental Process Regulation Of Lymphocyte Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT T Cell Differentiation Growth Hormone Receptor Signaling Pathway Cell Activation Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Lymphocyte Differentiation Leukocyte Activation Cell Surface Receptor Signaling Pathway Via STAT T Cell Activation Lymphocyte Mediated Immunity Regulation Of Immune Response Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Regulation Of Cell-cell Adhesion Mononuclear Cell Differentiation Lymphocyte Differentiation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Differentiation Immune System Process B Cell Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Differentiation Positive Regulation Of Lymphocyte Differentiation Regulation Of Cell Activation Positive Regulation Of Cell Development Leukocyte Mediated Immunity Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Apoptotic Process Leukocyte Differentiation	Cytokine-mediated Signaling Pathway Cytokine Receptor Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytokine Binding Receptor Complex Growth Hormone Receptor Signaling Pathway Via JAK-STAT External Side Of Plasma Membrane Protein Phosphorylation Regulation Of Cell Population Proliferation Response To Cytokine Response To Peptide Signal Transduction Phosphorylation Growth Hormone Receptor Signaling Pathway Plasma Membrane Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 Protein Kinase Activity Erythropoietin-mediated Signaling Pathway Extrinsic Component Of Plasma Membrane Interleukin-15-mediated Signaling Pathway Growth Hormone Receptor Binding Interleukin-2-mediated Signaling Pathway Kinase Activity Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Immune System Process Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Diacylglycerol-dependent Serine/threonine Kinase Activity Adaptive Immune Response Interleukin-3 Receptor Activity Histone H3T6 Kinase Activity Regulation Of Receptor Signaling Pathway Via JAK-STAT Intracellular Signal Transduction Leukocyte Activation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Negative Regulation Of Apoptotic Process Positive Regulation Of Interleukin-17 Production Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Platelet Aggregation Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway
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