JAK3 and VIL1

Number of citations of the paper that reports this interaction (PMID 17537734)
10

Data Source:
HPRD (in vivo)

		JAK3	VIL1
Gene Name		Janus kinase 3	villin 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Endomembrane System Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Ruffle Cytoplasm Microvillus Lamellipodium Filopodium Actin Filament Bundle Filopodium Tip Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Hormone Receptor Binding	Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lysophosphatidic Acid Binding Identical Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Actin Filament Binding
	Biological Process	Negative Regulation Of Dendritic Cell Cytokine Production Protein Phosphorylation Inflammatory Response Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Tyrosine Phosphorylation Of STAT Protein STAT Protein Import Into Nucleus Cell Migration Peptidyl-tyrosine Phosphorylation B Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Intracellular Signal Transduction Interleukin-4-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process T Cell Homeostasis Innate Immune Response Negative Regulation Of FasL Biosynthetic Process Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of T Cell Activation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of T Cell Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Response To Interleukin-9 Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Shape Response To Bacterium Positive Regulation Of Epithelial Cell Migration Actin Filament Polymerization Actin Filament Depolymerization Positive Regulation Of Cell Migration Epithelial Cell Differentiation Positive Regulation Of Actin Filament Bundle Assembly Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Nucleation Actin Filament Severing Regulation Of Actin Nucleation Actin Filament Capping Cytoplasmic Actin-based Contraction Involved In Cell Motility Regulation Of Wound Healing Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Lamellipodium Morphogenesis
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling Interleukin-7 signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		41 interactors: ALK APOA1 CD247 CD40 CD81 CDK1 CXCR4 ERBB3 FES GTF2B IKBKG IL2RB IL2RG IL4R IL7R INPP5D IRS1 IRS2 JAK1 JAK2 KHDRBS1 KIT LCK PIK3R1 PRMT5 PTK2B PTPN2 PTPN6 PTPRC SH2B2 SHB SOCS1 SOCS3 STAM STAM2 STAT3 STAT5A STAT5B TIAF1 UHRF2 VIL1	6 interactors: ACTA1 ACTG1 JAK3 PLCG1 SRC TEX11
Entrez ID		3718	7429
HPRD ID		02547	01898
Ensembl ID		ENSG00000105639
Uniprot IDs		P52333	P09327 Q53F91
PDB IDs		1YVJ 3LXK 3LXL 3PJC 3ZC6 4HVD 4HVG 4HVH 4HVI	1UNC 3FG7
Enriched GO Terms of Interacting Partners?		Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Signal Transduction Response To Growth Hormone Cytokine-mediated Signaling Pathway Signaling Cell Communication Immune System Process Defense Response Cellular Response To Organic Substance Regulation Of Cell Activation Cellular Response To Cytokine Stimulus Positive Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Stimulus Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Peptide JAK-STAT Cascade Immune Response Regulation Of Signal Transduction Regulation Of Signaling Response To Organic Substance Response To Cytokine Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation Regulation Of Kinase Activity Response To Hormone Regulation Of Phosphorylation Innate Immune Response Response To Peptide Hormone Immune Response-regulating Signaling Pathway Cellular Response To Hormone Stimulus Cell Proliferation Cellular Response To Organonitrogen Compound Regulation Of JAK-STAT Cascade Response To Peptide Regulation Of Cell Adhesion Regulation Of Phosphorus Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Proliferation	Vascular Endothelial Growth Factor Receptor Signaling Pathway Actomyosin Structure Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Regulation Of Immune Response Phagocytosis Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process System Development Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Multicellular Organismal Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Anatomical Structure Development Axon Guidance Blood Coagulation Locomotion Hemostasis Immune Response Regulation Of Immune System Process Defense Response Immune Response-regulating Signaling Pathway Myofibril Assembly Developmental Process Adherens Junction Organization Axonogenesis Ephrin Receptor Signaling Pathway Negative Regulation Of FasL Biosynthetic Process Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Actin Cytoskeleton Organization Cell Differentiation Positive Regulation Of Immune Response Neuron Projection Morphogenesis Actin Filament-based Process Endocytosis Cell Activation Cell Development Response To External Stimulus Response To Wounding Negative Regulation Of Dendritic Cell Cytokine Production Skeletal Muscle Fiber Adaptation
Tagcloud ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular kappab mediators molecule much mutants necrosis residues strongly tail traf traf2 traf3 traf5 traf6 transduction	2q33 2q34 artificial bcg brazilian exon fn1 il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed visceral
Tagcloud (Difference) ?		adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular kappab mediators molecule much mutants necrosis residues strongly tail traf traf2 traf3 traf5 traf6 transduction	2q33 2q34 artificial bcg brazilian exon fn1 il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed visceral
Tagcloud (Intersection) ?