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PTPN6 and FHL3
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
PTPN6
FHL3
Description
protein tyrosine phosphatase non-receptor type 6
four and a half LIM domains 3
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Membrane
Protein-containing Complex
Specific Granule Lumen
Alpha-beta T Cell Receptor Complex
Extracellular Exosome
Tertiary Granule Lumen
Stress Fiber
Nucleus
Cytoplasm
Focal Adhesion
Z Disc
Molecular Function
Phosphotyrosine Residue Binding
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Protein Binding
Hydrolase Activity
SH3 Domain Binding
Protein Kinase Binding
SH2 Domain Binding
Cell Adhesion Molecule Binding
Phosphorylation-dependent Protein Binding
Transcription Coregulator Activity
Actin Binding
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Biological Process
MAPK Cascade
Mitotic Cell Cycle
Pattern Recognition Receptor Signaling Pathway
Hematopoietic Progenitor Cell Differentiation
Neutrophil Activation Involved In Immune Response
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Protein Dephosphorylation
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Angiogenesis
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Platelet Formation
T Cell Costimulation
Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Mast Cell Activation Involved In Immune Response
Positive Regulation Of Cell Adhesion Mediated By Integrin
Peptidyl-tyrosine Dephosphorylation
Intracellular Signal Transduction
Megakaryocyte Development
T Cell Proliferation
T Cell Activation
Negative Regulation Of T Cell Proliferation
Natural Killer Cell Mediated Cytotoxicity
Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Regulation Of B Cell Differentiation
Positive Regulation Of Angiogenesis
Negative Regulation Of Innate Immune Response
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Negative Regulation Of B Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Receptor Signaling Pathway
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Inflammatory Response To Wounding
Negative Regulation Of Inflammatory Response To Wounding
CD27 Signaling Pathway
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Neutrophil Activation
Epididymis Development
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Muscle Organ Development
Actin Cytoskeleton Organization
Pathways
GPVI-mediated activation cascade
Regulation of KIT signaling
Signaling by ALK
PECAM1 interactions
Co-inhibition by PD-1
Signal regulatory protein family interactions
Platelet sensitization by LDL
Interleukin-3, Interleukin-5 and GM-CSF signaling
CD22 mediated BCR regulation
Neutrophil degranulation
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin-37 signaling
Interferon alpha/beta signaling
Interleukin receptor SHC signaling
Regulation of IFNA/IFNB signaling
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Nuclear events stimulated by ALK signaling in cancer
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Co-inhibition by BTLA
Drugs
Tiludronic acid
Diseases
GWAS
Mean corpuscular hemoglobin concentration (
29403010
)
Red blood cell fatty acid levels (
25500335
)
Refractive error (
32231278
)
Coronary artery disease (
29212778
33020668
)
Pulse pressure (
30578418
)
Interacting Genes
118 interacting genes:
AATK
ABL1
ACTN1
ACTN4
BCR
BLNK
BTLA
CAV1
CBL
CCDC88A
CD22
CD247
CD300LF
CD33
CD5
CD72
CD79A
CD79B
CDK1
CEACAM1
CLEC4A
CNKSR1
CSF2RB
CTNNB1
CTNND1
CUZD1
CXCR4
DOK1
EGFR
EPOR
ERBB2
ERBB3
ERBB4
ESR1
FAS
FCGR2B
FCRL3
FGFR4
FHL3
FLT3
GAB2
GHR
GRB2
H2BC3
HOXA10
IFNAR1
IGF1R
IL2RB
IL4R
IL6ST
INSR
IRS2
IRS4
JAK1
JAK2
JAK3
KDR
KHDRBS1
KIR2DL3
KIR2DL5A
KIT
KLRA1P
KLRB1
KLRC1
LAIR1
LAT
LCK
LCP2
LIFR
LILRB2
LILRB4
LMTK2
LYN
MPIG6B
MS4A2
MYH9
NOS1
OLIG1
PAG1
PDGFRB
PECAM1
PIK3R1
PILRA
PILRB
PLCG2
PRKCA
PRKCD
PTK2B
PTK7
PTPN11
PTPRC
ROR1
ROR2
ROS1
SHC1
SIGLEC10
SIGLEC11
SIGLEC12
SIRPA
SLAMF6
SNCA
SOS1
SPATA2
SRC
SSTR2
STAT5B
STAT6
SYK
TFG
TLR10
TMEM62
TNFRSF1A
TRAF3
TRAF6
TREML1
TYK2
VAV1
ZAP70
181 interacting genes:
A1CF
ACTB
ADAM15
ADAMTSL4
AIMP2
AMBP
ANKHD1
ARHGEF10
ARID5A
ASCL4
BARX2
C1orf94
CASS4
CBX8
CCDC198
CCND3
CDC25B
CDC42EP1
CDKN1A
CDKN2D
CHEK2
CIMAP1B
CLCN2
CNNM3
CNOT7
CORO1A
CREB5
CRIP3
CRYBA2
CSF1
CTBP2
CYSRT1
DCDC2B
DLGAP4
DMRT3
DUX4L9
E2F8
EFCAB12
EIF4EBP2
EPHA10
EPM2AIP1
ERBB3
EXOSC1
EXOSC5
FADS6
FAM110A
FAM222B
FAM90A1
FBXL18
FHL2
FOS
FOSL2
FOXN4
GARIN6
GATA1
GATA2
GCM2
GUCD1
HAPLN2
HIPK1
HOXA1
HSF2BP
HYAL2
HYCC1
IHO1
IKZF3
ITGA7
ITGB5
KANK2
KIDINS220
KIRREL2
KLF12
KLF3
KLF8
KPRP
KRTAP12-1
KRTAP12-2
KTI12
LASP1
LATS2
LHB
LMO2
LMO4
LNX1
LNX2
MAPK1
MED15
MMP14
MORF4L1
MPZL1
MRM3
MRPL27
MRRF
MSRB3
MTA1
MTUS2
MYBPC1
MYBPHL
MYCBP2
MYOZ3
MYPOP
MZF1
NDUFAB1
NFKBIB
NPRL3
P4HA2
PAK5
PATL1
PHC2
PHF21A
PIAS1
PIERCE1
PKP2
PLEKHF2
PLEKHG4B
POLR1H
PPIG
PRR35
PRR5L
PTPN6
QKI
QRICH1
RAB40B
RAD21
RASL12
RBM42
RFX3
RFX6
RHEBL1
RSPH14
RYBP
SAP30BP
SAXO1
SAXO4
SBF2
SDCBP
SH3GLB2
SHE
SLAIN1
SLC25A46
SLC44A3
SLU7
SMAD2
SMAD3
SMAD4
SNRPB
SNRPC
SNRPG
SPATA8
SPMAP2
SREBF2
SRF
SRGN
SUPT5H
TBC1D22B
THAP7
TLE5
TMEM108
TMEM14B
TMSB4X
TMX3
TRAF3IP2
TRIM27
TRIP6
TRO
TSGA10IP
TTLL10
TUBA3E
TYK2
TYMSOS
UBE2I
UBE2Q1
VWC2L
WDR25
WNK1
YPEL3
ZCCHC14
ZFP36
ZNF417
ZNF512B
ZNF587
Entrez ID
5777
2275
HPRD ID
01475
09101
Ensembl ID
ENSG00000111679
ENSG00000183386
Uniprot IDs
P29350
Q53XS4
Q13643
Q96C98
PDB IDs
1FPR
1GWZ
1X6C
2B3O
2RMX
2YU7
3PS5
4GRY
4GRZ
4GS0
4HJP
4HJQ
6SM5
8YHI
1WYH
2CUQ
2EHE
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Signal Transduction
Plasma Membrane
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Tyrosine Kinase Activity
Regulation Of Immune Response
Regulation Of Immune System Process
Enzyme-linked Receptor Protein Signaling Pathway
Immune System Process
Cytokine-mediated Signaling Pathway
Regulation Of Cell Activation
Immune Response-regulating Signaling Pathway
Leukocyte Activation
Cell Activation
Regulation Of MAPK Cascade
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Lymphocyte Activation
Membrane
Lymphocyte Activation
Receptor Complex
Positive Regulation Of MAPK Cascade
Positive Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Protein Kinase Activity
Regulation Of Signal Transduction
Regulation Of T Cell Activation
Regulation Of Intracellular Signal Transduction
Immune Response
Positive Regulation Of Intracellular Signal Transduction
Adaptive Immune Response
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cell Adhesion
Regulation Of Cell-cell Adhesion
Protein Phosphatase Binding
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune Response
Regulation Of Multicellular Organismal Process
Protein Phosphorylation
Regulation Of Leukocyte Proliferation
External Side Of Plasma Membrane
Fc Receptor Signaling Pathway
Kinase Activity
Immune Response-activating Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cell Population Proliferation
B Cell Activation
Mononuclear Cell Differentiation
Protein Binding
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Ventral Spinal Cord Interneuron Differentiation
Negative Regulation Of Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Gene Expression
Positive Regulation Of RNA Metabolic Process
Transcription Regulator Complex
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Metabolic Process
Chromatin Binding
Positive Regulation Of Biosynthetic Process
Regulation Of MiRNA Metabolic Process
Transcription Coregulator Binding
DNA-binding Transcription Factor Activity
Regulation Of Primary Metabolic Process
DNA Binding
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of MiRNA Transcription
Phosphatase Binding
Positive Regulation Of Macromolecule Metabolic Process
Cell Population Proliferation
Cis-regulatory Region Sequence-specific DNA Binding
Positive Regulation Of MiRNA Transcription
Identical Protein Binding
SMAD Protein Complex
Sequence-specific Double-stranded DNA Binding
Homeostasis Of Number Of Cells Within A Tissue
Positive Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Chromatin
Positive Regulation Of MiRNA Metabolic Process
Heteromeric SMAD Protein Complex
Myelination
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Axon Ensheathment
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