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PTPN6 and PTK2B
Number of citations of the paper that reports this interaction (PubMedID
10521452
)
0
Data Source:
HPRD
(in vitro, in vivo)
PTPN6
PTK2B
Description
protein tyrosine phosphatase non-receptor type 6
protein tyrosine kinase 2 beta
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Membrane
Protein-containing Complex
Specific Granule Lumen
Alpha-beta T Cell Receptor Complex
Extracellular Exosome
Tertiary Granule Lumen
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Cell Cortex
Postsynaptic Density
Membrane
NMDA Selective Glutamate Receptor Complex
Lamellipodium
Cell Junction
Dendrite
Growth Cone
Cell Projection
Neuronal Cell Body
Cell Body
Perinuclear Region Of Cytoplasm
Anchoring Junction
Apical Dendrite
Presynapse
Glutamatergic Synapse
Postsynaptic Density, Intracellular Component
Molecular Function
Phosphotyrosine Residue Binding
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Protein Binding
Hydrolase Activity
SH3 Domain Binding
Protein Kinase Binding
SH2 Domain Binding
Cell Adhesion Molecule Binding
Phosphorylation-dependent Protein Binding
Nucleotide Binding
Protein Kinase Activity
Calcium/calmodulin-dependent Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Signaling Receptor Activator Activity
Ionotropic Glutamate Receptor Binding
Neurotransmitter Receptor Regulator Activity
Biological Process
MAPK Cascade
Mitotic Cell Cycle
Pattern Recognition Receptor Signaling Pathway
Hematopoietic Progenitor Cell Differentiation
Neutrophil Activation Involved In Immune Response
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Protein Dephosphorylation
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Angiogenesis
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Platelet Formation
T Cell Costimulation
Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Mast Cell Activation Involved In Immune Response
Positive Regulation Of Cell Adhesion Mediated By Integrin
Peptidyl-tyrosine Dephosphorylation
Intracellular Signal Transduction
Megakaryocyte Development
T Cell Proliferation
T Cell Activation
Negative Regulation Of T Cell Proliferation
Natural Killer Cell Mediated Cytotoxicity
Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Regulation Of B Cell Differentiation
Positive Regulation Of Angiogenesis
Negative Regulation Of Innate Immune Response
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Negative Regulation Of B Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Receptor Signaling Pathway
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Inflammatory Response To Wounding
Negative Regulation Of Inflammatory Response To Wounding
CD27 Signaling Pathway
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Neutrophil Activation
Epididymis Development
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Angiogenesis
Neuron Migration
Regulation Of Cell-matrix Adhesion
Positive Regulation Of Cell-matrix Adhesion
Sprouting Angiogenesis
Adaptive Immune Response
Marginal Zone B Cell Differentiation
Immune System Process
Protein Phosphorylation
Apoptotic Process
Cellular Defense Response
Cytoskeleton Organization
Golgi Organization
Signal Transduction
Cell Surface Receptor Signaling Pathway
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Positive Regulation Of Signal Transduction
Positive Regulation Of Endothelial Cell Migration
Regulation Of Macrophage Chemotaxis
Positive Regulation Of Neuron Projection Development
Peptidyl-tyrosine Phosphorylation
Regulation Of Cell Adhesion
Positive Regulation Of Cell Migration
Negative Regulation Of Bone Mineralization
Positive Regulation Of Actin Filament Polymerization
Cortical Cytoskeleton Organization
Regulation Of Actin Cytoskeleton Organization
Tumor Necrosis Factor-mediated Signaling Pathway
Ionotropic Glutamate Receptor Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Activation Of Janus Kinase Activity
Negative Regulation Of Apoptotic Process
Negative Regulation Of Potassium Ion Transport
Negative Regulation Of Neuron Apoptotic Process
Bone Resorption
Negative Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Synaptic Plasticity
Regulation Of Multicellular Organismal Process
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Synaptic Transmission, Glutamatergic
Long-term Synaptic Potentiation
Protein-containing Complex Assembly
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Retinoic Acid
Cellular Response To Fluid Shear Stress
Endothelin Receptor Signaling Pathway
Regulation Of Postsynaptic Density Assembly
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of B Cell Chemotaxis
Pathways
GPVI-mediated activation cascade
Regulation of KIT signaling
Signaling by ALK
PECAM1 interactions
Co-inhibition by PD-1
Signal regulatory protein family interactions
Platelet sensitization by LDL
Interleukin-3, Interleukin-5 and GM-CSF signaling
CD22 mediated BCR regulation
Neutrophil degranulation
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin-37 signaling
Interferon alpha/beta signaling
Interleukin receptor SHC signaling
Regulation of IFNA/IFNB signaling
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Nuclear events stimulated by ALK signaling in cancer
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Co-inhibition by BTLA
Signal regulatory protein family interactions
VEGFA-VEGFR2 Pathway
RHOU GTPase cycle
Interleukin-2 signaling
Drugs
Tiludronic acid
Leflunomide
Genistein
4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide
Fostamatinib
Diseases
GWAS
Mean corpuscular hemoglobin concentration (
29403010
)
Red blood cell fatty acid levels (
25500335
)
Refractive error (
32231278
)
Adult body size (
32376654
)
Alzheimer's disease (
31473137
)
Alzheimer's disease (late onset) (
24162737
30617256
)
Alzheimer's disease in APOE e4- carriers (
25778476
)
Alzheimer's disease or family history of Alzheimer's disease (
30617256
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bone mineral content (
31790847
)
Bone mineral density (
31790847
)
Crohn's disease (
26192919
)
Dental caries (
23259602
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Family history of Alzheimer's disease (
30617256
)
Inflammatory bowel disease (
26192919
)
Monocyte count (
32888494
)
Schizophrenia (
29483656
)
Takayasu arteritis (
30498034
25604533
33308445
)
White blood cell count (
32888494
)
Interacting Genes
118 interacting genes:
AATK
ABL1
ACTN1
ACTN4
BCR
BLNK
BTLA
CAV1
CBL
CCDC88A
CD22
CD247
CD300LF
CD33
CD5
CD72
CD79A
CD79B
CDK1
CEACAM1
CLEC4A
CNKSR1
CSF2RB
CTNNB1
CTNND1
CUZD1
CXCR4
DOK1
EGFR
EPOR
ERBB2
ERBB3
ERBB4
ESR1
FAS
FCGR2B
FCRL3
FGFR4
FHL3
FLT3
GAB2
GHR
GRB2
H2BC3
HOXA10
IFNAR1
IGF1R
IL2RB
IL4R
IL6ST
INSR
IRS2
IRS4
JAK1
JAK2
JAK3
KDR
KHDRBS1
KIR2DL3
KIR2DL5A
KIT
KLRA1P
KLRB1
KLRC1
LAIR1
LAT
LCK
LCP2
LIFR
LILRB2
LILRB4
LMTK2
LYN
MPIG6B
MS4A2
MYH9
NOS1
OLIG1
PAG1
PDGFRB
PECAM1
PIK3R1
PILRA
PILRB
PLCG2
PRKCA
PRKCD
PTK2B
PTK7
PTPN11
PTPRC
ROR1
ROR2
ROS1
SHC1
SIGLEC10
SIGLEC11
SIGLEC12
SIRPA
SLAMF6
SNCA
SOS1
SPATA2
SRC
SSTR2
STAT5B
STAT6
SYK
TFG
TLR10
TMEM62
TNFRSF1A
TRAF3
TRAF6
TREML1
TYK2
VAV1
ZAP70
70 interacting genes:
ARHGAP21
ARHGAP5
ASAP1
ASAP2
BCAR1
CBL
CCR5
CRK
DLG3
DLG4
DLGAP3
EFS
EGFR
ERBB2
ERBB3
EWSR1
FGFR2
FGFR3
FLT1
FYN
GNA13
GRB2
GRIN2A
GSN
IL7R
ITGB2
ITGB3
JAK1
JAK2
JAK3
KCNA2
LCK
LPXN
LYN
MAP3K4
MAP4K4
MAPT
MATK
MCAM
MYH2
NEDD9
NPHP1
PDCD6IP
PDPK1
PIK3R1
PITPNM1
PITPNM2
PITPNM3
PRKCD
PTK2
PTPN11
PTPN12
PTPN6
PXN
RASA1
RB1CC1
SH2D3C
SHC1
SKAP2
SLC2A1
SNCA
SORBS2
SRC
STAP1
STAT3
SYK
TGFB1I1
TLN1
VAV1
ZAP70
Entrez ID
5777
2185
HPRD ID
01475
03131
Ensembl ID
ENSG00000111679
ENSG00000120899
Uniprot IDs
P29350
Q53XS4
Q14289
PDB IDs
1FPR
1GWZ
1X6C
2B3O
2RMX
2YU7
3PS5
4GRY
4GRZ
4GS0
4HJP
4HJQ
6SM5
8YHI
2LK4
3CC6
3ET7
3FZO
3FZP
3FZR
3FZS
3FZT
3GM1
3GM2
3GM3
3H3C
3U3F
4EKU
4H1J
4H1M
4R32
4XEF
4XEK
4XEV
5TO8
5TOB
6LF3
7PLL
8XOX
8YGX
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Signal Transduction
Plasma Membrane
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Tyrosine Kinase Activity
Regulation Of Immune Response
Regulation Of Immune System Process
Enzyme-linked Receptor Protein Signaling Pathway
Immune System Process
Cytokine-mediated Signaling Pathway
Regulation Of Cell Activation
Immune Response-regulating Signaling Pathway
Leukocyte Activation
Cell Activation
Regulation Of MAPK Cascade
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Lymphocyte Activation
Membrane
Lymphocyte Activation
Receptor Complex
Positive Regulation Of MAPK Cascade
Positive Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Protein Kinase Activity
Regulation Of Signal Transduction
Regulation Of T Cell Activation
Regulation Of Intracellular Signal Transduction
Immune Response
Positive Regulation Of Intracellular Signal Transduction
Adaptive Immune Response
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cell Adhesion
Regulation Of Cell-cell Adhesion
Protein Phosphatase Binding
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune Response
Regulation Of Multicellular Organismal Process
Protein Phosphorylation
Regulation Of Leukocyte Proliferation
External Side Of Plasma Membrane
Fc Receptor Signaling Pathway
Kinase Activity
Immune Response-activating Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cell Population Proliferation
B Cell Activation
Mononuclear Cell Differentiation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Focal Adhesion
Phosphotyrosine Residue Binding
Protein Tyrosine Kinase Activity
Plasma Membrane
Peptidyl-tyrosine Phosphorylation
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Cell Adhesion
Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Protein Kinase Activity
Cytosol
Phosphorylation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cytoplasm
Regulation Of Cell Communication
Regulation Of Signaling
Protein Phosphorylation
Positive Regulation Of Cell Adhesion
Cell Activation
Regulation Of MAPK Cascade
Positive Regulation Of Intracellular Signal Transduction
Cellular Response To Growth Factor Stimulus
Regulation Of Intracellular Signal Transduction
Kinase Activity
Growth Hormone Receptor Signaling Pathway
Cell Migration
Leukocyte Activation
Epidermal Growth Factor Receptor Signaling Pathway
Cell-cell Junction
Regulation Of Cell-cell Adhesion
Response To Growth Factor
T Cell Costimulation
Positive Regulation Of MAPK Cascade
Intracellular Signal Transduction
Anchoring Junction
ERBB Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Immune System Process
Cell Motility
Cell Adhesion
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Protein Kinase Binding
Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Receptor Tyrosine Kinase Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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