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JAK3 and IL2RB
Number of citations of the paper that reports this interaction (PubMedID
10825200
)
55
Data Source:
HPRD
(in vitro, in vivo)
JAK3
IL2RB
Description
Janus kinase 3
interleukin 2 receptor subunit beta
Image
GO Annotations
Cellular Component
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Endomembrane System
Membrane
Extrinsic Component Of Plasma Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Endosome
Cytosol
Plasma Membrane
Interleukin-2 Receptor Complex
External Side Of Plasma Membrane
Cell Surface
Membrane
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Growth Hormone Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Phosphatase Binding
Cytokine Receptor Activity
Interleukin-2 Receptor Activity
Protein Binding
Coreceptor Activity
Interleukin-2 Binding
Interleukin-15 Receptor Activity
Biological Process
Adaptive Immune Response
Immune System Process
Negative Regulation Of Dendritic Cell Cytokine Production
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Glycoprotein Biosynthetic Process
Cytokine-mediated Signaling Pathway
Cell Differentiation
B Cell Differentiation
Negative Regulation Of Interleukin-10 Production
Negative Regulation Of Interleukin-12 Production
Intracellular Signal Transduction
Interleukin-15-mediated Signaling Pathway
Interleukin-4-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Regulation Of Apoptotic Process
T Cell Homeostasis
Innate Immune Response
Negative Regulation Of T-helper 1 Cell Differentiation
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Regulation Of Alpha-beta T Cell Activation
Negative Regulation Of T Cell Activation
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Regulation Of T Cell Apoptotic Process
Negative Regulation Of Thymocyte Apoptotic Process
Response To Interleukin-2
Response To Interleukin-4
Response To Interleukin-15
Response To Interleukin-9
Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of T-helper 17 Cell Lineage Commitment
Signal Transduction
Immunoglobulin Mediated Immune Response
Cytokine-mediated Signaling Pathway
Interleukin-15-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Negative Regulation Of Apoptotic Process
Positive Regulation Of Phagocytosis
Protein-containing Complex Assembly
Pathways
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by ALK
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Interleukin receptor SHC signaling
Potential therapeutics for SARS
RAF/MAP kinase cascade
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-2 signaling
Interleukin receptor SHC signaling
Drugs
2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
R-348
Ruxolitinib
Tofacitinib
Baricitinib
Fostamatinib
Abrocitinib
Zanubrutinib
Denileukin diftitox
Aldesleukin
Basiliximab
Daclizumab
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Asthma (
20860503
32296059
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
L-selectin levels (
25576479
)
Lack of premeditation (
30718321
)
Mean corpuscular volume (
27863252
)
Rheumatoid arthritis (
23143596
24390342
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Tuberculosis (
24057671
)
Type 1 diabetes (
21829393
)
Interacting Genes
43 interacting genes:
ALK
APOA1
CD247
CD40
CD81
CDK1
CISH
CXCR4
ERBB3
FES
GTF2B
IKBKG
IL2RB
IL2RG
IL4R
IL7R
INPP5D
IRS1
IRS2
JAK1
JAK2
KHDRBS1
KIT
LCK
LNX1
PIK3R1
PRMT5
PTK2B
PTPN2
PTPN6
PTPRC
SH2B2
SHB
SOCS1
SOCS2
SOCS3
STAM
STAM2
STAT3
STAT5A
STAT5B
UHRF2
VIL1
29 interacting genes:
CISH
EIF3B
FYN
GRB2
HGS
IL15
IL15RA
IL2
IL2RA
IL2RG
JAK1
JAK3
LCK
LYN
MTDH
PIK3R1
PTPN6
RACK1
RAF1
SHB
SHC1
SOCS1
SOCS3
STAT1
STAT3
STAT5A
STAT5B
SYK
TRIP13
Entrez ID
3718
3560
HPRD ID
02547
00896
Ensembl ID
ENSG00000105639
ENSG00000100385
Uniprot IDs
P52333
P14784
PDB IDs
1YVJ
3LXK
3LXL
3PJC
3ZC6
3ZEP
4HVD
4HVG
4HVH
4HVI
4I6Q
4QPS
4QT1
4RIO
4V0G
4Z16
5LWM
5LWN
5TOZ
5TTS
5TTU
5TTV
5VO6
5W86
5WFJ
6AAK
6DA4
6DB3
6DB4
6DUD
6GL9
6GLA
6GLB
6HZV
6NY4
7APF
7APG
7C3N
7Q6H
7UYV
8EXM
2B5I
2ERJ
3QAZ
4GS7
5M5E
6E8K
7S2S
Enriched GO Terms of Interacting Partners
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Cell Surface Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Positive Regulation Of Developmental Process
Positive Regulation Of Immune System Process
Signal Transduction
Regulation Of Immune System Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cell Adhesion
Positive Regulation Of Lymphocyte Activation
Regulation Of Hemopoiesis
Enzyme-linked Receptor Protein Signaling Pathway
Lymphocyte Activation
Regulation Of Cell Differentiation
Positive Regulation Of Cell Activation
Regulation Of Cell Development
Regulation Of Developmental Process
Regulation Of Lymphocyte Activation
Cell Surface Receptor Signaling Pathway Via JAK-STAT
T Cell Differentiation
Growth Hormone Receptor Signaling Pathway
Cell Activation
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Regulation Of Lymphocyte Differentiation
Leukocyte Activation
Cell Surface Receptor Signaling Pathway Via STAT
T Cell Activation
Lymphocyte Mediated Immunity
Regulation Of Immune Response
Regulation Of Multicellular Organismal Development
Positive Regulation Of Cell Adhesion
Regulation Of Programmed Cell Death
Regulation Of Multicellular Organismal Process
Regulation Of Cell-cell Adhesion
Mononuclear Cell Differentiation
Lymphocyte Differentiation
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cell Differentiation
Immune System Process
B Cell Activation
Positive Regulation Of Cell-cell Adhesion
Positive Regulation Of T Cell Activation
Positive Regulation Of Leukocyte Differentiation
Positive Regulation Of Lymphocyte Differentiation
Regulation Of Cell Activation
Positive Regulation Of Cell Development
Leukocyte Mediated Immunity
Positive Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Apoptotic Process
Leukocyte Differentiation
Cytokine-mediated Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Hemopoiesis
Lymphocyte Activation
Regulation Of Multicellular Organismal Development
Interleukin-15-mediated Signaling Pathway
Positive Regulation Of Cell-cell Adhesion
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of T Cell Activation
Leukocyte Activation
Regulation Of Developmental Process
Positive Regulation Of Leukocyte Cell-cell Adhesion
Interleukin-2-mediated Signaling Pathway
Regulation Of Lymphocyte Differentiation
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Regulation Of Cell-cell Adhesion
Cell Surface Receptor Signaling Pathway Via STAT
Regulation Of Lymphocyte Activation
Cell Activation
Positive Regulation Of Lymphocyte Differentiation
Interleukin-9-mediated Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Cell Adhesion
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Regulation Of Cell Activation
Positive Regulation Of Developmental Process
Regulation Of Cell Adhesion
Cell Differentiation
Mononuclear Cell Differentiation
Regulation Of Cell Development
Growth Hormone Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Regulation Of T Cell Differentiation
Positive Regulation Of Leukocyte Differentiation
Leukocyte Differentiation
Regulation Of Multicellular Organismal Process
T Cell Activation
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Signal Transduction
Lymphocyte Differentiation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Lymphocyte Proliferation
Cellular Developmental Process
Mononuclear Cell Proliferation
Positive Regulation Of T Cell Differentiation
Interleukin-7-mediated Signaling Pathway
Regulation Of Cell Differentiation
Activated T Cell Proliferation
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