JAK3 and ERBB3

Number of citations of the paper that reports this interaction (PubMedID 16273093)
0

Data Source:
BioGRID (unspecified method)

		JAK3	ERBB3
Description		Janus kinase 3	erb-b2 receptor tyrosine kinase 3
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GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Endomembrane System Membrane Extrinsic Component Of Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Extracellular Region Extracellular Space Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane ERBB3:ERBB2 Complex Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Protein Tyrosine Kinase Activator Activity Ubiquitin Protein Ligase Binding Signaling Receptor Activity Neuregulin Receptor Activity Neuregulin Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity
	Biological Process	Adaptive Immune Response Immune System Process Negative Regulation Of Dendritic Cell Cytokine Production Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Glycoprotein Biosynthetic Process Cytokine-mediated Signaling Pathway Cell Differentiation B Cell Differentiation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Intracellular Signal Transduction Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Apoptotic Process T Cell Homeostasis Innate Immune Response Negative Regulation Of T-helper 1 Cell Differentiation Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Alpha-beta T Cell Activation Negative Regulation Of T Cell Activation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of T Cell Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Response To Interleukin-9 Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of T-helper 17 Cell Lineage Commitment	Endocardial Cushion Development Negative Regulation Of Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Peripheral Nervous System Development Heart Development Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Schwann Cell Differentiation Schwann Cell Development Cranial Nerve Development Neuron Differentiation ERBB2-ERBB3 Signaling Pathway Wound Healing Regulation Of Cell Population Proliferation Myelination Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Secretion Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade Motor Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		Interleukin-7 signaling Interleukin-7 signaling Signaling by ALK RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling Potential therapeutics for SARS
Drugs		2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one R-348 Ruxolitinib Tofacitinib Baricitinib Fostamatinib Abrocitinib Zanubrutinib	Tucatinib
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma	Type I diabetes mellitus Lethal congenital contractural syndrome (LCCS)
GWAS			Age at first sexual intercourse ( 34211149) Allergic disease (asthma, hay fever or eczema) ( 29785011) Alopecia areata ( 25608926) Anorexia nervosa ( 28494655) Asthma ( 31959851 31619474 30929738) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Body mass index ( 32700739) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Household income (MTAG) ( 31844048) Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Polycystic ovary syndrome ( 26416764) Refractive error ( 32231278) Smoking initiation ( 33082346 30617275) Type 1 diabetes ( 17554300 18198356 18978792 19430480 21829393 30572963 17554260) Vitiligo ( 22951725)
Interacting Genes		43 interacting genes: ALK APOA1 CD247 CD40 CD81 CDK1 CISH CXCR4 ERBB3 FES GTF2B IKBKG IL2RB IL2RG IL4R IL7R INPP5D IRS1 IRS2 JAK1 JAK2 KHDRBS1 KIT LCK LNX1 PIK3R1 PRMT5 PTK2B PTPN2 PTPN6 PTPRC SH2B2 SHB SOCS1 SOCS2 SOCS3 STAM STAM2 STAT3 STAT5A STAT5B UHRF2 VIL1	196 interacting genes: ABL1 ABL2 ACYP1 AGTR2 ALDOA ATP5ME BCAR3 BEND5 BLK BLNK BTK CALM1 CD82 CDC25C CDK5 CFL1 CHN2 CRK CRKL CSPG5 DAB1 DAPP1 DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 DYRK1A EGF EGFR EGR1 ENOPH1 ERBB2 ERBB4 ERG28 EYA4 EZR FAM241B FER FES FGFR1 FGR FHL3 FKBP1A FLNA FLYWCH1 GABARAPL1 GABARAPL2 GRAP2 GRB2 GRB7 HCK HDAC6 HINT1 HSH2D HSPA1A HSPA8 IL6ST ILKAP INPPL1 IRF2BP2 ITK JAK2 JAK3 JUP LAMTOR2 LBHD1 LCK LCP2 LRRC7 LYN MAP1B MATK MTMR1 MTMR10 MTMR2 MTMR6 MTMR8 MTMR9 MUC1 MUC4 MYCBP MYCBP2 NCK1 NCK2 NDUFAB1 NEDD4 NRG1 NRG2 NSMCE1 ODF2L PA2G4 PDGFRA PFDN2 PFDN4 PHPT1 PIK3R1 PIK3R2 PIK3R3 PIN4 PLCG1 PLCG2 PPM1A PPM1B PPM1F PPM1K PPM1M PRDX5 PRKACA PRRG4 PSMA5 PTEN PTGES3 PTK2 PTK2B PTK6 PTPDC1 PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRH PTPRR RALGAPA1 RASA1 RASA4 RGS4 RIN1 RNF41 RPN1 RTN4 RWDD2A S100A10 SAP18 SELENOK SF3B6 SH2B1 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3A SH2D3C SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA SLA2 SMIM20 SNAP91 SNCA SNRPB2 SOCS2 SOCS3 SOCS5 SOCS6 SORL1 SOS1 SRC SRPK2 STAP1 STYX SYK SYNM TBCA TCEA2 TEC TMA7 TMEM134 TMEM14A TMEM230 TNS1 TNS2 TNS3 TNS4 TPTE TRIR TVP23B TXK TXN TXNL4A VAV1 VAV2 VAV3 VTA1 WRNIP1 YES1 YWHAZ ZAP70 ZNF207 ZNF532
Entrez ID		3718	2065
HPRD ID		02547	01820
Ensembl ID		ENSG00000105639	ENSG00000065361
Uniprot IDs		P52333	P21860
PDB IDs		1YVJ 3LXK 3LXL 3PJC 3ZC6 3ZEP 4HVD 4HVG 4HVH 4HVI 4I6Q 4QPS 4QT1 4RIO 4V0G 4Z16 5LWM 5LWN 5TOZ 5TTS 5TTU 5TTV 5VO6 5W86 5WFJ 6AAK 6DA4 6DB3 6DB4 6DUD 6GL9 6GLA 6GLB 6HZV 6NY4 7APF 7APG 7C3N 7Q6H 7UYV 8EXM	1M6B 2L9U 3KEX 3LMG 3P11 4LEO 4P59 4RIW 4RIX 4RIY 5CUS 5O4O 5O7P 6KBI 6OP9 7BHE 7BHF 7D85 7MN5 7MN6 7MN8
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Developmental Process Positive Regulation Of Immune System Process Signal Transduction Regulation Of Immune System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Hemopoiesis Enzyme-linked Receptor Protein Signaling Pathway Lymphocyte Activation Regulation Of Cell Differentiation Positive Regulation Of Cell Activation Regulation Of Cell Development Regulation Of Developmental Process Regulation Of Lymphocyte Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT T Cell Differentiation Growth Hormone Receptor Signaling Pathway Cell Activation Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Lymphocyte Differentiation Leukocyte Activation Cell Surface Receptor Signaling Pathway Via STAT T Cell Activation Lymphocyte Mediated Immunity Regulation Of Immune Response Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Regulation Of Cell-cell Adhesion Mononuclear Cell Differentiation Lymphocyte Differentiation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Differentiation Immune System Process B Cell Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Differentiation Positive Regulation Of Lymphocyte Differentiation Regulation Of Cell Activation Positive Regulation Of Cell Development Leukocyte Mediated Immunity Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Apoptotic Process Leukocyte Differentiation	Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity ERBB Signaling Pathway Intracellular Signal Transduction Phosphoprotein Phosphatase Activity Regulation Of Signal Transduction Cytosol Regulation Of Signaling Regulation Of Cell Communication Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction Phosphate-containing Compound Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Protein Tyrosine Phosphatase Activity Dephosphorylation Regulation Of Immune Response Cell Activation Leukocyte Activation Cytoplasm Antigen Receptor-mediated Signaling Pathway Protein Phosphorylation Protein Modification Process Immune Response-activating Signaling Pathway Regulation Of Cell Adhesion Protein Kinase Activity Positive Regulation Of Signal Transduction Phosphorylation Immune Response-regulating Signaling Pathway Protein Dephosphorylation Positive Regulation Of Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cell Migration Receptor Tyrosine Kinase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Immune Response Lymphocyte Activation Fc Receptor Mediated Stimulatory Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of MAPK Cascade Regulation Of Immune System Process
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