PTPN6 and CD33

Number of citations of the paper that reports this interaction (PMID 10206955)
16

Data Source:
HPRD (in vitro, in vivo)

		PTPN6	CD33
Gene Name		protein tyrosine phosphatase, non-receptor type 6	CD33 molecule
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Cell-cell Junction Membrane Alpha-beta T Cell Receptor Complex Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Phosphotyrosine Binding Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding Protein Kinase Binding SH2 Domain Binding	Receptor Activity Protein Binding Carbohydrate Binding
	Biological Process	Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Protein Dephosphorylation Apoptotic Process G-protein Coupled Receptor Signaling Pathway Blood Coagulation Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Platelet Formation T Cell Costimulation Abortive Mitotic Cell Cycle Positive Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Dephosphorylation Megakaryocyte Development Negative Regulation Of T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of MAP Kinase Activity Regulation Of B Cell Differentiation Negative Regulation Of Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Regulation Of G1/S Transition Of Mitotic Cell Cycle	Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Proliferation
Pathways		Costimulation by the CD28 family Signaling by SCF-KIT Interferon gamma signaling Regulation of KIT signaling Interleukin receptor SHC signaling Interferon alpha/beta signaling Regulation of IFNA signaling Interferon Signaling Cytokine Signaling in Immune system Signal regulatory protein (SIRP) family interactions Cell surface interactions at the vascular wall PECAM1 interactions Signaling by Interleukins Platelet homeostasis Platelet sensitization by LDL Interleukin receptor SHC signaling PD-1 signaling Interleukin-2 signaling Interleukin-3, 5 and GM-CSF signaling Regulation of IFNG signaling Growth hormone receptor signaling Adaptive Immune System
Drugs			Gemtuzumab ozogamicin
Diseases
GWAS			Alzheimer's disease ( 18976728) Alzheimer's disease (late onset) ( 21460841)
Protein-Protein Interactions		98 interactors: ABL1 ACTN1 ACTN4 BCR BLNK BTLA C6orf25 CAV1 CBL CD22 CD247 CD300LF CD33 CD5 CD72 CD79A CD79B CEACAM1 CLEC4A CSF2RB CTNNB1 CTNND1 CUZD1 CXCR4 DOK1 EGFR EPOR ESR1 FAS FCGR2B FCRL3 FHL3 FLT3 GAB2 GHR GRB2 HOXA10 IFNAR1 IL2RB IL4R IL6ST INSR IRS2 IRS4 JAK1 JAK2 JAK3 KDR KHDRBS1 KIR2DL3 KIR2DL5A KIT KLRAP1 KLRB1 KLRC1 LAIR1 LCK LCP2 LIFR LILRB2 LILRB4 LYN MS4A2 MYH9 NOS1 PAG1 PECAM1 PIK3R1 PILRA PILRB PRKCA PRKCD PTK2B PTPN11 PTPRC ROS1 SHC1 SIGLEC10 SIGLEC11 SIGLEC12 SIRPA SLAMF6 SOS1 SPATA2 SRC SSTR2 STAT5B STAT6 SYK TFG TLR10 TMEM62 TNFRSF1A TRAF6 TREML1 TYK2 VAV1 ZAP70	6 interactors: HERC3 KRT31 KRT40 PTPN11 PTPN6 SRC
Entrez ID		5777	945
HPRD ID		01475	01165
Ensembl ID		ENSG00000111679	ENSG00000105383
Uniprot IDs		P29350 Q53XS4	P20138 Q546G0
PDB IDs		1FPR 1GWZ 1X6C 2B3O 2RMX 2YU7 3PS5 4GRY 4GRZ 4GS0 4HJP 4HJQ
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Immune System Process Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Regulation Of Immune Response Cellular Response To Stimulus Regulation Of Cell Activation Cell Activation Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Signal Transduction Immune Response Immune Response-regulating Signaling Pathway Defense Response Regulation Of Cell-cell Adhesion Cellular Response To Organic Substance Regulation Of Lymphocyte Activation Innate Immune Response Positive Regulation Of Immune System Process Response To Organic Substance Cell Migration Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell Adhesion Blood Coagulation Hemostasis Cell Motility Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Body Fluid Levels Intracellular Signal Transduction Leukocyte Activation Leukocyte Differentiation Leukocyte Migration Fc Receptor Signaling Pathway Regulation Of Signaling Response To Cytokine Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Stress	Abortive Mitotic Cell Cycle T Cell Costimulation Megakaryocyte Development Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Platelet Formation Positive Regulation Of Homotypic Cell-cell Adhesion Platelet Morphogenesis Regulation Of Interferon-gamma-mediated Signaling Pathway Megakaryocyte Differentiation Regulation Of Response To Interferon-gamma Leukocyte Migration Bone Development Positive Regulation Of Cell-cell Adhesion Myeloid Cell Differentiation Regulation Of MAP Kinase Activity Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Lymphocyte Activation Blood Coagulation Hemostasis Regulation Of Intracellular Transport Response To Peptide Hormone Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Cellular Response To Insulin Stimulus Skeletal System Development Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus Wound Healing Ephrin Receptor Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Regulation Of MAPK Cascade Regulation Of Cell Adhesion Hemopoiesis Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion
Tagcloud ?		a2 ag cd45 chimera chimeras chimeric coupling diminished enzymatic fails hcp hemopoietic initiated inositol j45 jurkat ligation lymphoid phosphatase phospholipase phosphotyrosine ptp1c rescue shp shptp surprisingly tcr transduction unlike	abnormalities allowing antigens author capacities carefully cd11b defective discrepancies english fi fluorochromes granules granulocytes granulopoiesis inconsistencies mature maturing medline monocytes perspectives pools preparing publications retrieved reviewing sensors standardization storage
Tagcloud (Difference) ?		a2 ag cd45 chimera chimeras chimeric coupling diminished enzymatic fails hcp hemopoietic initiated inositol j45 jurkat ligation lymphoid phosphatase phospholipase phosphotyrosine ptp1c rescue shp shptp surprisingly tcr transduction unlike	abnormalities allowing antigens author capacities carefully cd11b defective discrepancies english fi fluorochromes granules granulocytes granulopoiesis inconsistencies mature maturing medline monocytes perspectives pools preparing publications retrieved reviewing sensors standardization storage
Tagcloud (Intersection) ?