PTPN6 and IRS4

Number of citations of the paper that reports this interaction (PMID 12774026)
6

Data Source:
HPRD (in vitro)

		PTPN6	IRS4
Gene Name		protein tyrosine phosphatase, non-receptor type 6	insulin receptor substrate 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Cell-cell Junction Membrane Alpha-beta T Cell Receptor Complex Extracellular Vesicular Exosome	Cytosol Plasma Membrane
	Molecular Function	Phosphotyrosine Binding Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding Protein Kinase Binding SH2 Domain Binding	Signal Transducer Activity SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Protein Dephosphorylation Apoptotic Process G-protein Coupled Receptor Signaling Pathway Blood Coagulation Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Platelet Formation T Cell Costimulation Abortive Mitotic Cell Cycle Positive Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Dephosphorylation Megakaryocyte Development Negative Regulation Of T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of MAP Kinase Activity Regulation Of B Cell Differentiation Negative Regulation Of Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Regulation Of G1/S Transition Of Mitotic Cell Cycle	Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Lipid Metabolic Process
Pathways		Costimulation by the CD28 family Signaling by SCF-KIT Interferon gamma signaling Regulation of KIT signaling Interleukin receptor SHC signaling Interferon alpha/beta signaling Regulation of IFNA signaling Interferon Signaling Cytokine Signaling in Immune system Signal regulatory protein (SIRP) family interactions Cell surface interactions at the vascular wall PECAM1 interactions Signaling by Interleukins Platelet homeostasis Platelet sensitization by LDL Interleukin receptor SHC signaling PD-1 signaling Interleukin-2 signaling Interleukin-3, 5 and GM-CSF signaling Regulation of IFNG signaling Growth hormone receptor signaling Adaptive Immune System	IRS-related events triggered by IGF1R Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IGF1R signaling cascade
Drugs
Diseases
GWAS
Protein-Protein Interactions		98 interactors: ABL1 ACTN1 ACTN4 BCR BLNK BTLA C6orf25 CAV1 CBL CD22 CD247 CD300LF CD33 CD5 CD72 CD79A CD79B CEACAM1 CLEC4A CSF2RB CTNNB1 CTNND1 CUZD1 CXCR4 DOK1 EGFR EPOR ESR1 FAS FCGR2B FCRL3 FHL3 FLT3 GAB2 GHR GRB2 HOXA10 IFNAR1 IL2RB IL4R IL6ST INSR IRS2 IRS4 JAK1 JAK2 JAK3 KDR KHDRBS1 KIR2DL3 KIR2DL5A KIT KLRAP1 KLRB1 KLRC1 LAIR1 LCK LCP2 LIFR LILRB2 LILRB4 LYN MS4A2 MYH9 NOS1 PAG1 PECAM1 PIK3R1 PILRA PILRB PRKCA PRKCD PTK2B PTPN11 PTPRC ROS1 SHC1 SIGLEC10 SIGLEC11 SIGLEC12 SIRPA SLAMF6 SOS1 SPATA2 SRC SSTR2 STAT5B STAT6 SYK TFG TLR10 TMEM62 TNFRSF1A TRAF6 TREML1 TYK2 VAV1 ZAP70	17 interactors: CRK CRKL EGFR ERBB2 GRB2 IGF1R MTNR1A MTNR1B NISCH PIK3CA PIK3R1 PRKCZ PTPN11 PTPN6 SOCS6 SOCS7 YWHAG
Entrez ID		5777	8471
HPRD ID		01475	04620
Ensembl ID		ENSG00000111679	ENSG00000133124
Uniprot IDs		P29350 Q53XS4	O14654
PDB IDs		1FPR 1GWZ 1X6C 2B3O 2RMX 2YU7 3PS5 4GRY 4GRZ 4GS0 4HJP 4HJQ
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Immune System Process Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Regulation Of Immune Response Cellular Response To Stimulus Regulation Of Cell Activation Cell Activation Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Signal Transduction Immune Response Immune Response-regulating Signaling Pathway Defense Response Regulation Of Cell-cell Adhesion Cellular Response To Organic Substance Regulation Of Lymphocyte Activation Innate Immune Response Positive Regulation Of Immune System Process Response To Organic Substance Cell Migration Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell Adhesion Blood Coagulation Hemostasis Cell Motility Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Body Fluid Levels Intracellular Signal Transduction Leukocyte Activation Leukocyte Differentiation Leukocyte Migration Fc Receptor Signaling Pathway Regulation Of Signaling Response To Cytokine Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Stress	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Peptide Cellular Response To Insulin Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Insulin Receptor Signaling Pathway Cellular Response To Hormone Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Insulin Response To Peptide Hormone Regulation Of Phosphorylation Response To Peptide Regulation Of Protein Kinase Activity Response To Organonitrogen Compound Response To Hormone Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Signaling Regulation Of T Cell Activation Signal Transduction Response To Organic Substance Signaling Cell Communication Regulation Of Cell-cell Adhesion Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Response To Growth Factor Regulation Of Lymphocyte Activation Regulation Of MAPK Cascade Regulation Of Catalytic Activity Regulation Of Cell Activation Fc Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process T Cell Costimulation Regulation Of Immune Response
Tagcloud ?		a2 ag cd45 chimera chimeras chimeric coupling diminished enzymatic fails hcp hemopoietic initiated inositol j45 jurkat ligation lymphoid phosphatase phospholipase phosphotyrosine ptp1c rescue shp shptp surprisingly tcr transduction unlike	arg35 arhg5 cbl cblb del digested downscaled doxycycline dyn2 errfi flp hek293 hsp71 hsp7c input l747 optimisation pc9 ptpra purifications quantities retroviral s752 sos1 sos2 tagged tap usb3b wipf2
Tagcloud (Difference) ?		a2 ag cd45 chimera chimeras chimeric coupling diminished enzymatic fails hcp hemopoietic initiated inositol j45 jurkat ligation lymphoid phosphatase phospholipase phosphotyrosine ptp1c rescue shp shptp surprisingly tcr transduction unlike	arg35 arhg5 cbl cblb del digested downscaled doxycycline dyn2 errfi flp hek293 hsp71 hsp7c input l747 optimisation pc9 ptpra purifications quantities retroviral s752 sos1 sos2 tagged tap usb3b wipf2
Tagcloud (Intersection) ?