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JAK3 and KHDRBS1
Number of citations of the paper that reports this interaction (PMID
9045636
)
17
Data Source:
HPRD
(in vitro)
JAK3
KHDRBS1
Gene Name
Janus kinase 3
KH domain containing, RNA binding, signal transduction associated 1
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Cytoskeleton
Endomembrane System
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Nucleus
Nucleoplasm
Cytoplasm
Membrane
Grb2-Sos Complex
Molecular Function
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein Phosphatase Binding
Hormone Receptor Binding
DNA Binding
RNA Binding
SH3/SH2 Adaptor Activity
Protein Binding
Poly(A) Binding
Poly(U) RNA Binding
SH3 Domain Binding
Protein Complex Binding
Identical Protein Binding
Poly(A) RNA Binding
Biological Process
Negative Regulation Of Dendritic Cell Cytokine Production
Protein Phosphorylation
Inflammatory Response
Enzyme Linked Receptor Protein Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Tyrosine Phosphorylation Of STAT Protein
STAT Protein Import Into Nucleus
Cell Migration
Peptidyl-tyrosine Phosphorylation
B Cell Differentiation
Erythrocyte Differentiation
Negative Regulation Of Interleukin-10 Production
Negative Regulation Of Interleukin-12 Production
Intracellular Signal Transduction
Interleukin-4-mediated Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Positive Regulation Of T Cell Proliferation
Regulation Of Apoptotic Process
T Cell Homeostasis
Innate Immune Response
Negative Regulation Of FasL Biosynthetic Process
Negative Regulation Of T-helper 1 Cell Differentiation
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of T Cell Activation
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Regulation Of T Cell Apoptotic Process
Negative Regulation Of Thymocyte Apoptotic Process
Response To Interleukin-2
Response To Interleukin-4
Response To Interleukin-15
Response To Interleukin-9
Positive Regulation Of Dendritic Cell Apoptotic Process
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
G2/M Transition Of Mitotic Cell Cycle
Transcription, DNA-templated
MRNA Processing
Cell Cycle Arrest
Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Proliferation
Positive Regulation Of Signal Transduction
Regulation Of Protein Stability
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Translational Initiation
Regulation Of RNA Export From Nucleus
Positive Regulation Of RNA Export From Nucleus
Pathways
Signaling by GPCR
G-protein beta:gamma signalling
Cytokine Signaling in Immune system
Signaling by Interleukins
GPCR downstream signaling
Interleukin receptor SHC signaling
G beta:gamma signalling through PI3Kgamma
Interleukin receptor SHC signaling
Interleukin-7 signaling
GPVI-mediated activation cascade
Interleukin-2 signaling
Platelet activation, signaling and aggregation
Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions
41 interactors:
ALK
APOA1
CD247
CD40
CD81
CDK1
CXCR4
ERBB3
FES
GTF2B
IKBKG
IL2RB
IL2RG
IL4R
IL7R
INPP5D
IRS1
IRS2
JAK1
JAK2
KHDRBS1
KIT
LCK
PIK3R1
PRMT5
PTK2B
PTPN2
PTPN6
PTPRC
SH2B2
SHB
SOCS1
SOCS3
STAM
STAM2
STAT3
STAT5A
STAT5B
TIAF1
UHRF2
VIL1
109 interactors:
ABI2
ACTB
AGO1
AHI1
AMPH
APBB1
ARHGEF4
ARHGEF9
AZIN1
BAIAP2L1
BTK
BZRAP1
CBL
CD2AP
CDK1
CIRBP
CREB3L3
CREBBP
CRK
CRKL
CSK
DDX5
DHX9
DLG1
DLG2
DLG3
DLG4
DNMBP
DOCK2
DOCK3
EFEMP1
EMG1
FGR
FNBP4
FRK
FYN
GAS7
GPHN
GRAP
GRAP2
GRB2
HCK
HNRNPK
INSR
ITK
ITSN1
ITSN2
JAK3
KHDRBS3
LCK
LYN
MAPK1
MIA2
MPP6
MYO1C
MYO7A
NCF1
NCK1
NCK2
NCKIPSD
NPHP1
OSTF1
PACSIN1
PIK3R1
PIK3R3
PLCG1
PLCG2
POT1
PPP1R13B
PRMT1
PSTPIP1
PTBP2
PTK6
PTPN6
RALY
RAPSN
RASA1
RBFOX2
RBM7
RBMX
RUSC2
SASH1
SCG5
SH3PXD2A
SH3YL1
SKAP2
SMAD2
SMARCA2
SNX30
SNX9
SORBS1
SPATA13
SRC
SSFA2
STAT3
STUB1
TBL1X
TJP1
TNFSF11
TUBB3
U2AF2
UBA52
UBASH3B
VAV1
WBP4
YES1
YTHDC1
ZBTB7A
ZDHHC6
Entrez ID
3718
10657
HPRD ID
02547
03926
Ensembl ID
ENSG00000105639
ENSG00000121774
Uniprot IDs
P52333
Q07666
PDB IDs
1YVJ
3LXK
3LXL
3PJC
3ZC6
4HVD
4HVG
4HVH
4HVI
2XA6
3QHE
Enriched GO Terms of Interacting Partners
?
Regulation Of Immune Response
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Immune System Process
Enzyme Linked Receptor Protein Signaling Pathway
Growth Hormone Receptor Signaling Pathway
Cellular Response To Growth Hormone Stimulus
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Signal Transduction
Response To Growth Hormone
Cytokine-mediated Signaling Pathway
Signaling
Cell Communication
Immune System Process
Defense Response
Cellular Response To Organic Substance
Regulation Of Cell Activation
Cellular Response To Cytokine Stimulus
Positive Regulation Of Cell Activation
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Stimulus
Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Cellular Response To Peptide
JAK-STAT Cascade
Immune Response
Regulation Of Signal Transduction
Regulation Of Signaling
Response To Organic Substance
Response To Cytokine
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Lymphocyte Activation
Regulation Of Kinase Activity
Response To Hormone
Regulation Of Phosphorylation
Innate Immune Response
Response To Peptide Hormone
Immune Response-regulating Signaling Pathway
Cellular Response To Hormone Stimulus
Cell Proliferation
Cellular Response To Organonitrogen Compound
Regulation Of JAK-STAT Cascade
Response To Peptide
Regulation Of Cell Adhesion
Regulation Of Phosphorus Metabolic Process
Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Cell Proliferation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Fc Receptor Signaling Pathway
Signaling
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cell Communication
Peptidyl-tyrosine Autophosphorylation
Innate Immune Response
Signal Transduction
Immune Response-regulating Signaling Pathway
Immune Response
Endocytosis
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Locomotion
Movement Of Cell Or Subcellular Component
Cellular Response To Stimulus
Positive Regulation Of Metabolic Process
Cell Surface Receptor Signaling Pathway
Defense Response
Positive Regulation Of Immune Response
Regulation Of Immune System Process
Cellular Response To Peptide Hormone Stimulus
Neurotrophin TRK Receptor Signaling Pathway
Phagocytosis
Cellular Response To Peptide
Positive Regulation Of Immune System Process
Neurotrophin Signaling Pathway
Positive Regulation Of Signal Transduction
Cellular Response To Growth Factor Stimulus
Regulation Of Immune Response
Epidermal Growth Factor Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Response To Growth Factor
Antigen Receptor-mediated Signaling Pathway
Cell Differentiation
Regulation Of Catalytic Activity
Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Regulation Of Cellular Component Organization
Immune System Process
Response To Stimulus
Regulation Of Signaling
Cell Projection Organization
Intracellular Signal Transduction
Cellular Response To Organic Substance
Regulation Of Metabolic Process
Tagcloud
?
adhesion
affinity
bind
cd40
cd40ct
cytoplasmic
dispensable
dominantly
extensive
icam
ikappabalpha
implicated
incapable
intercellular
kappab
mediators
molecule
much
mutants
necrosis
residues
strongly
tail
traf
traf2
traf3
traf5
traf6
transduction
Tagcloud (Difference)
?
adhesion
affinity
bind
cd40
cd40ct
cytoplasmic
dispensable
dominantly
extensive
icam
ikappabalpha
implicated
incapable
intercellular
kappab
mediators
molecule
much
mutants
necrosis
residues
strongly
tail
traf
traf2
traf3
traf5
traf6
transduction
Tagcloud (Intersection)
?