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JAK3 and PTPN2
Number of citations of the paper that reports this interaction (PubMedID
11909529
)
0
Data Source:
HPRD
(in vitro, in vivo)
JAK3
PTPN2
Description
Janus kinase 3
protein tyrosine phosphatase non-receptor type 2
Image
GO Annotations
Cellular Component
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Endomembrane System
Membrane
Extrinsic Component Of Plasma Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
Plasma Membrane
Membrane
Endosome Lumen
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Growth Hormone Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Phosphatase Binding
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Integrin Binding
Protein Binding
Hydrolase Activity
Protein Kinase Binding
Syntaxin Binding
Receptor Tyrosine Kinase Binding
STAT Family Protein Binding
Biological Process
Adaptive Immune Response
Immune System Process
Negative Regulation Of Dendritic Cell Cytokine Production
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Glycoprotein Biosynthetic Process
Cytokine-mediated Signaling Pathway
Cell Differentiation
B Cell Differentiation
Negative Regulation Of Interleukin-10 Production
Negative Regulation Of Interleukin-12 Production
Intracellular Signal Transduction
Interleukin-15-mediated Signaling Pathway
Interleukin-4-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Regulation Of Apoptotic Process
T Cell Homeostasis
Innate Immune Response
Negative Regulation Of T-helper 1 Cell Differentiation
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Regulation Of Alpha-beta T Cell Activation
Negative Regulation Of T Cell Activation
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Regulation Of T Cell Apoptotic Process
Negative Regulation Of Thymocyte Apoptotic Process
Response To Interleukin-2
Response To Interleukin-4
Response To Interleukin-15
Response To Interleukin-9
Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of T-helper 17 Cell Lineage Commitment
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Lipid Storage
B Cell Differentiation
T Cell Differentiation
Erythrocyte Differentiation
Peptidyl-tyrosine Dephosphorylation
Insulin Receptor Recycling
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Glucose Homeostasis
Negative Regulation Of Macrophage Differentiation
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Negative Regulation Of T Cell Receptor Signaling Pathway
Negative Regulation Of Chemotaxis
Regulation Of Type II Interferon-mediated Signaling Pathway
Negative Regulation Of Type II Interferon-mediated Signaling Pathway
Regulation Of Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Interleukin-6-mediated Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway
Negative Regulation Of Interleukin-2-mediated Signaling Pathway
Negative Regulation Of Interleukin-4-mediated Signaling Pathway
Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway
Negative Regulation Of Positive Thymic T Cell Selection
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of PERK-mediated Unfolded Protein Response
Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by ALK
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Interleukin receptor SHC signaling
Potential therapeutics for SARS
Negative regulation of MET activity
Interleukin-37 signaling
PKR-mediated signaling
Drugs
2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
R-348
Ruxolitinib
Tofacitinib
Baricitinib
Fostamatinib
Abrocitinib
Zanubrutinib
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
Type I diabetes mellitus
GWAS
Alopecia areata (
25608926
)
Autoimmune thyroid disease (
32581359
)
Autoimmune traits (pleiotropy) (
30572963
)
Body mass index (
25673413
)
C-reactive protein levels (
30388399
21300955
)
Celiac disease (
20190752
22057235
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
17554261
28067908
25489960
21102463
17554300
18587394
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Esophageal cancer (squamous cell) (
22960999
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
28067908
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
Lead levels in blood (
25820613
)
Lymphocyte count (
32888494
)
Mean reticulocyte volume (
32888494
)
Medication use (thyroid preparations) (
31015401
)
Psoriasis (
28537254
)
Red blood cell count (
32888494
)
Rheumatoid arthritis (
30423114
24390342
23143596
22446963
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Selective IgA deficiency (
27723758
)
Type 1 diabetes (
25751624
21829393
19430480
18978792
17554260
)
Interacting Genes
43 interacting genes:
ALK
APOA1
CD247
CD40
CD81
CDK1
CISH
CXCR4
ERBB3
FES
GTF2B
IKBKG
IL2RB
IL2RG
IL4R
IL7R
INPP5D
IRS1
IRS2
JAK1
JAK2
KHDRBS1
KIT
LCK
LNX1
PIK3R1
PRMT5
PTK2B
PTPN2
PTPN6
PTPRC
SH2B2
SHB
SOCS1
SOCS2
SOCS3
STAM
STAM2
STAT3
STAT5A
STAT5B
UHRF2
VIL1
26 interacting genes:
CDK1
CDK2
CDK5
CRYAA
EGFR
FAM220A
FKBP4
GHR
GJB1
HMGB1
INSR
ITGA1
JAK1
JAK3
KPNB1
OCLN
PDGFRB
SHC1
SRC
STAT1
STAT3
STAT5A
STAT5B
STX17
TMEM132D
UBC
Entrez ID
3718
5771
HPRD ID
02547
06768
Ensembl ID
ENSG00000105639
ENSG00000175354
Uniprot IDs
P52333
A8K3N4
K7EQG9
P17706
Q59F91
PDB IDs
1YVJ
3LXK
3LXL
3PJC
3ZC6
3ZEP
4HVD
4HVG
4HVH
4HVI
4I6Q
4QPS
4QT1
4RIO
4V0G
4Z16
5LWM
5LWN
5TOZ
5TTS
5TTU
5TTV
5VO6
5W86
5WFJ
6AAK
6DA4
6DB3
6DB4
6DUD
6GL9
6GLA
6GLB
6HZV
6NY4
7APF
7APG
7C3N
7Q6H
7UYV
8EXM
1L8K
6ZZ4
7F5N
7F5O
7UAD
8U0H
8UH6
9C54
9C55
9C56
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Positive Regulation Of Developmental Process
Positive Regulation Of Immune System Process
Signal Transduction
Regulation Of Immune System Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cell Adhesion
Positive Regulation Of Lymphocyte Activation
Regulation Of Hemopoiesis
Enzyme-linked Receptor Protein Signaling Pathway
Lymphocyte Activation
Regulation Of Cell Differentiation
Positive Regulation Of Cell Activation
Regulation Of Cell Development
Regulation Of Developmental Process
Regulation Of Lymphocyte Activation
Cell Surface Receptor Signaling Pathway Via JAK-STAT
T Cell Differentiation
Growth Hormone Receptor Signaling Pathway
Cell Activation
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Regulation Of Lymphocyte Differentiation
Leukocyte Activation
Cell Surface Receptor Signaling Pathway Via STAT
T Cell Activation
Lymphocyte Mediated Immunity
Regulation Of Immune Response
Regulation Of Multicellular Organismal Development
Positive Regulation Of Cell Adhesion
Regulation Of Programmed Cell Death
Regulation Of Multicellular Organismal Process
Regulation Of Cell-cell Adhesion
Mononuclear Cell Differentiation
Lymphocyte Differentiation
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cell Differentiation
Immune System Process
B Cell Activation
Positive Regulation Of Cell-cell Adhesion
Positive Regulation Of T Cell Activation
Positive Regulation Of Leukocyte Differentiation
Positive Regulation Of Lymphocyte Differentiation
Regulation Of Cell Activation
Positive Regulation Of Cell Development
Leukocyte Mediated Immunity
Positive Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Apoptotic Process
Leukocyte Differentiation
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Interleukin-9-mediated Signaling Pathway
Growth Hormone Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Cell Surface Receptor Signaling Pathway Via STAT
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Phosphatase Binding
Interleukin-7-mediated Signaling Pathway
Interleukin-15-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Kinase Activity
Phosphorylation
Positive Regulation Of Cell Population Proliferation
Kinase Activity
Protein Tyrosine Kinase Activity
Protein Phosphorylation
Interleukin-4-mediated Signaling Pathway
Positive Regulation Of Growth
CCR5 Chemokine Receptor Binding
Response To Cytokine
Regulation Of Apoptotic Process
Response To Peptide
Cytokine-mediated Signaling Pathway
Regulation Of Programmed Cell Death
Taurine Metabolic Process
Regulation Of Growth
Regulation Of Macromolecule Biosynthetic Process
Response To Peptide Hormone
Positive Regulation Of MAPK Cascade
Regulation Of Developmental Growth
Positive Regulation Of Myeloid Cell Differentiation
Nuclear Glucocorticoid Receptor Binding
Regulation Of Erythrocyte Differentiation
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Population Proliferation
Cell Migration
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Tyrosine Kinase Activator Activity
Shc-EGFR Complex
Interleukin-6-mediated Signaling Pathway
Response To Interleukin-15
Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Carbohydrate Catabolic Process
Regulation Of Multicellular Organism Growth
Regulation Of Macromolecule Metabolic Process
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