PTPN6 and MYH9

Number of citations of the paper that reports this interaction (PubMedID 12705885)
0

Data Source:
HPRD (in vitro, in vivo)

		PTPN6	MYH9
Description		protein tyrosine phosphatase non-receptor type 6	myosin heavy chain 9
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Protein-containing Complex Specific Granule Lumen Alpha-beta T Cell Receptor Complex Extracellular Exosome Tertiary Granule Lumen	Stress Fiber Ruffle Immunological Synapse Uropod Nucleus Cytoplasm Golgi Apparatus Spindle Actomyosin Contractile Ring Cytosol Cytoskeleton Plasma Membrane Brush Border Adherens Junction Focal Adhesion Cell Cortex COP9 Signalosome Cytoplasmic Side Of Plasma Membrane Cell Surface Actin Cytoskeleton Membrane Myosin Complex Myosin II Complex Nuclear Body Cortical Cytoskeleton Cell Leading Edge Cytoplasmic Vesicle Neuromuscular Junction Cleavage Furrow Myosin Filament Protein-containing Complex Actomyosin Cortical Granule Extracellular Exosome Myosin II Filament Supramolecular Fiber
	Molecular Function	Phosphotyrosine Residue Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity SH3 Domain Binding Protein Kinase Binding SH2 Domain Binding Cell Adhesion Molecule Binding Phosphorylation-dependent Protein Binding	Microfilament Motor Activity Nucleotide Binding Virus Receptor Activity RNA Binding Cytoskeletal Motor Activity Actin Binding Integrin Binding Protein Binding Calmodulin Binding ATP Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity ADP Binding Cadherin Binding Actin Filament Binding
	Biological Process	MAPK Cascade Mitotic Cell Cycle Pattern Recognition Receptor Signaling Pathway Hematopoietic Progenitor Cell Differentiation Neutrophil Activation Involved In Immune Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Protein Dephosphorylation G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Platelet Formation T Cell Costimulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Mast Cell Activation Involved In Immune Response Positive Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Dephosphorylation Intracellular Signal Transduction Megakaryocyte Development T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Regulation Of B Cell Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Innate Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Inflammatory Response To Wounding Negative Regulation Of Inflammatory Response To Wounding CD27 Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Neutrophil Activation Epididymis Development Regulation Of G1/S Transition Of Mitotic Cell Cycle	Meiotic Spindle Organization Cell Morphogenesis Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Plasma Membrane Repair Membrane Protein Ectodomain Proteolysis Phagocytosis, Engulfment Cytoskeleton Organization Cell Adhesion Integrin-mediated Signaling Pathway Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Cytoskeleton Organization Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Lysosome Localization Cytokinetic Process Uropod Organization Regulation Of Actin Filament-based Process Endodermal Cell Differentiation Blood Vessel Endothelial Cell Migration Regulated Exocytosis Symbiont Entry Into Host Cell Cell Motility Leukocyte Migration Establishment Of Meiotic Spindle Localization Cytoplasmic Actin-based Contraction Involved In Cell Motility Cortical Granule Exocytosis Platelet Aggregation Cell-cell Adhesion Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Regulation Of Plasma Membrane Repair
Pathways		GPVI-mediated activation cascade Regulation of KIT signaling Signaling by ALK PECAM1 interactions Co-inhibition by PD-1 Signal regulatory protein family interactions Platelet sensitization by LDL Interleukin-3, Interleukin-5 and GM-CSF signaling CD22 mediated BCR regulation Neutrophil degranulation Interferon gamma signaling Regulation of IFNG signaling Interleukin-37 signaling Interferon alpha/beta signaling Interleukin receptor SHC signaling Regulation of IFNA/IFNB signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Nuclear events stimulated by ALK signaling in cancer Growth hormone receptor signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Co-inhibition by BTLA	Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea CD163 mediating an anti-inflammatory response FCGR3A-mediated phagocytosis Signaling by ALK fusions and activated point mutants
Drugs		Tiludronic acid	Artenimol
Diseases			MYH9-related kidney diseases, including: Epstein syndrome; Fechtner syndrome Macrothrombocytopenia; May-Hegglin anomaly; Sebastian syndrome; Fechtner syndrome; Epstein syndrome Deafness, autosomal dominant
GWAS		Mean corpuscular hemoglobin concentration ( 29403010) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278)	Diabetic kidney disease ( 26305897) End-stage renal disease (non-diabetic) ( 20532800) Glomerulosclerosis ( 20668430) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference ( 30108283) Language performance in older adults (adjusted for episodic memory) ( 28577822) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Optic nerve measurement (rim area) ( 20395239) Platelet count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		118 interacting genes: AATK ABL1 ACTN1 ACTN4 BCR BLNK BTLA CAV1 CBL CCDC88A CD22 CD247 CD300LF CD33 CD5 CD72 CD79A CD79B CDK1 CEACAM1 CLEC4A CNKSR1 CSF2RB CTNNB1 CTNND1 CUZD1 CXCR4 DOK1 EGFR EPOR ERBB2 ERBB3 ERBB4 ESR1 FAS FCGR2B FCRL3 FGFR4 FHL3 FLT3 GAB2 GHR GRB2 H2BC3 HOXA10 IFNAR1 IGF1R IL2RB IL4R IL6ST INSR IRS2 IRS4 JAK1 JAK2 JAK3 KDR KHDRBS1 KIR2DL3 KIR2DL5A KIT KLRA1P KLRB1 KLRC1 LAIR1 LAT LCK LCP2 LIFR LILRB2 LILRB4 LMTK2 LYN MPIG6B MS4A2 MYH9 NOS1 OLIG1 PAG1 PDGFRB PECAM1 PIK3R1 PILRA PILRB PLCG2 PRKCA PRKCD PTK2B PTK7 PTPN11 PTPRC ROR1 ROR2 ROS1 SHC1 SIGLEC10 SIGLEC11 SIGLEC12 SIRPA SLAMF6 SNCA SOS1 SPATA2 SRC SSTR2 STAT5B STAT6 SYK TFG TLR10 TMEM62 TNFRSF1A TRAF3 TRAF6 TREML1 TYK2 VAV1 ZAP70	31 interacting genes: ANXA1 ASCC2 ATG9B CASP4 CBL CD163 CSNK2A1 CXCR4 DUX4 FXR1 GRIN1 MEN1 MTDH MYBPC3 MYH10 MYL9 MYOM1 MYOM2 NUDCD2 OVGP1 PPP2CA PTPN6 RAC1 RNF10 S100A4 SNCA TTN TUFM UBE2I WEE2-AS1 YWHAZ
Entrez ID		5777	4627
HPRD ID		01475	01177
Ensembl ID		ENSG00000111679	ENSG00000100345
Uniprot IDs		P29350 Q53XS4	P35579
PDB IDs		1FPR 1GWZ 1X6C 2B3O 2RMX 2YU7 3PS5 4GRY 4GRZ 4GS0 4HJP 4HJQ 6SM5 8YHI	2LNK 3ZWH 4CFQ 4CFR 4ETO
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Signal Transduction Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Regulation Of Immune Response Regulation Of Immune System Process Enzyme-linked Receptor Protein Signaling Pathway Immune System Process Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Immune Response-regulating Signaling Pathway Leukocyte Activation Cell Activation Regulation Of MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation Membrane Lymphocyte Activation Receptor Complex Positive Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Protein Kinase Activity Regulation Of Signal Transduction Regulation Of T Cell Activation Regulation Of Intracellular Signal Transduction Immune Response Positive Regulation Of Intracellular Signal Transduction Adaptive Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Protein Phosphatase Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Regulation Of Multicellular Organismal Process Protein Phosphorylation Regulation Of Leukocyte Proliferation External Side Of Plasma Membrane Fc Receptor Signaling Pathway Kinase Activity Immune Response-activating Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cell Population Proliferation B Cell Activation Mononuclear Cell Differentiation	Structural Constituent Of Muscle Myosin Filament Actomyosin Structure Organization M Band Actin Cytoskeleton Organization Actin Filament-based Process Sarcomere Organization Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Skeletal Muscle Organ Development Cytoplasm Striated Muscle Myosin Thick Filament Positive Regulation Of Signal Transduction Myofibril Assembly Extraocular Skeletal Muscle Development Cytosol Organelle Organization Myosin Heavy Chain Binding Calcium Ion Binding Positive Regulation Of Transport Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly Membraneless Organelle Assembly Positive Regulation Of Protein Secretion Supramolecular Fiber Intracellular Signal Transduction Positive Regulation Of Secretion By Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase A Signaling Regulation Of Microtubule Polymerization Positive Regulation Of Secretion Cytoskeleton Organization Cell Cortex Regulation Of Transport Cardiac Myofibril Assembly Inflammatory Response Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Secretion By Cell Regulation Of Intracellular Signal Transduction Regulation Of Synaptic Plasticity Glutamatergic Synapse Actin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Vesicle Fusion Regulation Of Secretion Regulation Of Microtubule Polymerization Or Depolymerization
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