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PTPN6 and TREML1
Number of citations of the paper that reports this interaction (PMID
12393607
)
10
Data Source:
HPRD
(in vivo)
PTPN6
TREML1
Gene Name
protein tyrosine phosphatase, non-receptor type 6
triggering receptor expressed on myeloid cells-like 1
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Cytosol
Cell-cell Junction
Membrane
Alpha-beta T Cell Receptor Complex
Extracellular Vesicular Exosome
Plasma Membrane
Cell Surface
Integral Component Of Membrane
Platelet Alpha Granule
Molecular Function
Phosphotyrosine Binding
Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
SH2 Domain Binding
Protein Binding
Biological Process
Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Protein Dephosphorylation
Apoptotic Process
G-protein Coupled Receptor Signaling Pathway
Blood Coagulation
Cell Proliferation
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Platelet Formation
T Cell Costimulation
Abortive Mitotic Cell Cycle
Positive Regulation Of Cell Adhesion Mediated By Integrin
Peptidyl-tyrosine Dephosphorylation
Megakaryocyte Development
Negative Regulation Of T Cell Proliferation
Natural Killer Cell Mediated Cytotoxicity
Negative Regulation Of MAP Kinase Activity
Regulation Of B Cell Differentiation
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
B Cell Receptor Signaling Pathway
Negative Regulation Of B Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Receptor Signaling Pathway
Leukocyte Migration
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Regulation Of Type I Interferon-mediated Signaling Pathway
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Calcium-mediated Signaling
Platelet Activation
Innate Immune Response
Pathways
Costimulation by the CD28 family
Signaling by SCF-KIT
Interferon gamma signaling
Regulation of KIT signaling
Interleukin receptor SHC signaling
Interferon alpha/beta signaling
Regulation of IFNA signaling
Interferon Signaling
Cytokine Signaling in Immune system
Signal regulatory protein (SIRP) family interactions
Cell surface interactions at the vascular wall
PECAM1 interactions
Signaling by Interleukins
Platelet homeostasis
Platelet sensitization by LDL
Interleukin receptor SHC signaling
PD-1 signaling
Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
Regulation of IFNG signaling
Growth hormone receptor signaling
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
98 interactors:
ABL1
ACTN1
ACTN4
BCR
BLNK
BTLA
C6orf25
CAV1
CBL
CD22
CD247
CD300LF
CD33
CD5
CD72
CD79A
CD79B
CEACAM1
CLEC4A
CSF2RB
CTNNB1
CTNND1
CUZD1
CXCR4
DOK1
EGFR
EPOR
ESR1
FAS
FCGR2B
FCRL3
FHL3
FLT3
GAB2
GHR
GRB2
HOXA10
IFNAR1
IL2RB
IL4R
IL6ST
INSR
IRS2
IRS4
JAK1
JAK2
JAK3
KDR
KHDRBS1
KIR2DL3
KIR2DL5A
KIT
KLRAP1
KLRB1
KLRC1
LAIR1
LCK
LCP2
LIFR
LILRB2
LILRB4
LYN
MS4A2
MYH9
NOS1
PAG1
PECAM1
PIK3R1
PILRA
PILRB
PRKCA
PRKCD
PTK2B
PTPN11
PTPRC
ROS1
SHC1
SIGLEC10
SIGLEC11
SIGLEC12
SIRPA
SLAMF6
SOS1
SPATA2
SRC
SSTR2
STAT5B
STAT6
SYK
TFG
TLR10
TMEM62
TNFRSF1A
TRAF6
TREML1
TYK2
VAV1
ZAP70
2 interactors:
PTPN11
PTPN6
Entrez ID
5777
340205
HPRD ID
01475
11645
Ensembl ID
ENSG00000111679
ENSG00000161911
Uniprot IDs
P29350
Q53XS4
Q86YW5
PDB IDs
1FPR
1GWZ
1X6C
2B3O
2RMX
2YU7
3PS5
4GRY
4GRZ
4GS0
4HJP
4HJQ
2FRG
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Immune System Process
Immune System Process
Signaling
Enzyme Linked Receptor Protein Signaling Pathway
Cell Communication
Regulation Of Immune Response
Cellular Response To Stimulus
Regulation Of Cell Activation
Cell Activation
Response To Stimulus
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Activation
Positive Regulation Of Signal Transduction
Immune Response
Immune Response-regulating Signaling Pathway
Defense Response
Regulation Of Cell-cell Adhesion
Cellular Response To Organic Substance
Regulation Of Lymphocyte Activation
Innate Immune Response
Positive Regulation Of Immune System Process
Response To Organic Substance
Cell Migration
Peptidyl-tyrosine Autophosphorylation
Positive Regulation Of Cell Adhesion
Blood Coagulation
Hemostasis
Cell Motility
Regulation Of Cell Adhesion
Positive Regulation Of T Cell Activation
Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Peptidyl-tyrosine Phosphorylation
Regulation Of Signal Transduction
Cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of Body Fluid Levels
Intracellular Signal Transduction
Leukocyte Activation
Leukocyte Differentiation
Leukocyte Migration
Fc Receptor Signaling Pathway
Regulation Of Signaling
Response To Cytokine
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Response To Stress
Abortive Mitotic Cell Cycle
Megakaryocyte Development
Platelet Formation
Platelet Morphogenesis
Regulation Of Interferon-gamma-mediated Signaling Pathway
Regulation Of Response To Interferon-gamma
Megakaryocyte Differentiation
Regulation Of Cell Adhesion Mediated By Integrin
Regulation Of Type I Interferon-mediated Signaling Pathway
T Cell Costimulation
Regulation Of Cytokine-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Cellular Response To Type I Interferon
Response To Type I Interferon
Interferon-gamma-mediated Signaling Pathway
Cellular Response To Interferon-gamma
Hematopoietic Progenitor Cell Differentiation
Response To Interferon-gamma
Peptidyl-tyrosine Dephosphorylation
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Cell Adhesion
Positive Regulation Of T Cell Activation
Negative Regulation Of Cortisol Secretion
Negative Regulation Of Growth Hormone Secretion
Positive Regulation Of Homotypic Cell-cell Adhesion
Leukocyte Migration
Bone Development
Positive Regulation Of Cell-cell Adhesion
Regulation Of Innate Immune Response
Myeloid Cell Differentiation
Protein Dephosphorylation
Regulation Of MAP Kinase Activity
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Peptide
Negative Regulation Of Glucocorticoid Secretion
Regulation Of Cell-cell Adhesion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Adhesion
Regulation Of Lymphocyte Activation
Regulation Of Mitotic Cell Cycle
Blood Coagulation
Hemostasis
Regulation Of Intracellular Transport
Cytokine-mediated Signaling Pathway
Response To Peptide Hormone
Negative Regulation Of B Cell Receptor Signaling Pathway
Dephosphorylation
Immune Response-regulating Signaling Pathway
Tagcloud
?
a2
ag
cd45
chimera
chimeras
chimeric
coupling
diminished
enzymatic
fails
hcp
hemopoietic
initiated
inositol
j45
jurkat
ligation
lymphoid
phosphatase
phospholipase
phosphotyrosine
ptp1c
rescue
shp
shptp
surprisingly
tcr
transduction
unlike
Tagcloud (Difference)
?
a2
ag
cd45
chimera
chimeras
chimeric
coupling
diminished
enzymatic
fails
hcp
hemopoietic
initiated
inositol
j45
jurkat
ligation
lymphoid
phosphatase
phospholipase
phosphotyrosine
ptp1c
rescue
shp
shptp
surprisingly
tcr
transduction
unlike
Tagcloud (Intersection)
?