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PTPN6 and SOS1
Number of citations of the paper that reports this interaction (PubMedID
8632004
)
0
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
PTPN6
SOS1
Description
protein tyrosine phosphatase non-receptor type 6
SOS Ras/Rac guanine nucleotide exchange factor 1
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Membrane
Protein-containing Complex
Specific Granule Lumen
Alpha-beta T Cell Receptor Complex
Extracellular Exosome
Tertiary Granule Lumen
Cytoplasm
Cytosol
Plasma Membrane
Postsynaptic Density
Neuronal Cell Body
Glutamatergic Synapse
GTPase Complex
Molecular Function
Phosphotyrosine Residue Binding
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Protein Binding
Hydrolase Activity
SH3 Domain Binding
Protein Kinase Binding
SH2 Domain Binding
Cell Adhesion Molecule Binding
Phosphorylation-dependent Protein Binding
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Epidermal Growth Factor Receptor Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Protein Heterodimerization Activity
Molecular Condensate Scaffold Activity
Biological Process
MAPK Cascade
Mitotic Cell Cycle
Pattern Recognition Receptor Signaling Pathway
Hematopoietic Progenitor Cell Differentiation
Neutrophil Activation Involved In Immune Response
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Protein Dephosphorylation
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Angiogenesis
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Platelet Formation
T Cell Costimulation
Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Mast Cell Activation Involved In Immune Response
Positive Regulation Of Cell Adhesion Mediated By Integrin
Peptidyl-tyrosine Dephosphorylation
Intracellular Signal Transduction
Megakaryocyte Development
T Cell Proliferation
T Cell Activation
Negative Regulation Of T Cell Proliferation
Natural Killer Cell Mediated Cytotoxicity
Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Regulation Of B Cell Differentiation
Positive Regulation Of Angiogenesis
Negative Regulation Of Innate Immune Response
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Negative Regulation Of B Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Receptor Signaling Pathway
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Inflammatory Response To Wounding
Negative Regulation Of Inflammatory Response To Wounding
CD27 Signaling Pathway
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Neutrophil Activation
Epididymis Development
Regulation Of G1/S Transition Of Mitotic Cell Cycle
B Cell Homeostasis
Hair Follicle Development
Lymphocyte Homeostasis
Response To Ischemia
Heart Morphogenesis
Cardiac Atrium Morphogenesis
Pericardium Morphogenesis
Regulation Of Transcription By RNA Polymerase II
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Small GTPase-mediated Signal Transduction
Ras Protein Signal Transduction
Vitellogenesis
Axon Guidance
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Schwann Cell Development
Cytokine-mediated Signaling Pathway
Regulation Of T Cell Differentiation In Thymus
Multicellular Organism Growth
Fc-epsilon Receptor Signaling Pathway
T Cell Activation
Regulation Of Cell Population Proliferation
Regulation Of T Cell Proliferation
Myelination
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Insulin-like Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Blood Vessel Morphogenesis
B Cell Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Small GTPase Mediated Signal Transduction
Roof Of Mouth Development
Eyelid Development In Camera-type Eye
Heart Trabecula Morphogenesis
Midbrain Morphogenesis
Regulation Of Pro-B Cell Differentiation
Pathways
GPVI-mediated activation cascade
Regulation of KIT signaling
Signaling by ALK
PECAM1 interactions
Co-inhibition by PD-1
Signal regulatory protein family interactions
Platelet sensitization by LDL
Interleukin-3, Interleukin-5 and GM-CSF signaling
CD22 mediated BCR regulation
Neutrophil degranulation
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin-37 signaling
Interferon alpha/beta signaling
Interleukin receptor SHC signaling
Regulation of IFNA/IFNB signaling
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Nuclear events stimulated by ALK signaling in cancer
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Co-inhibition by BTLA
SOS-mediated signalling
SOS-mediated signalling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
Regulation of KIT signaling
Signalling to RAS
Signalling to RAS
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
NRAGE signals death through JNK
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
SHC-related events triggered by IGF1R
SHC-related events triggered by IGF1R
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
GRB2:SOS provides linkage to MAPK signaling for Integrins
NCAM signaling for neurite out-growth
G alpha (12/13) signalling events
Activation of RAC1
Constitutive Signaling by EGFRvIII
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
RAF/MAP kinase cascade
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor signalling cascade
MET activates RAS signaling
RET signaling
Interleukin-15 signaling
RAC1 GTPase cycle
Activated NTRK2 signals through RAS
Erythropoietin activates RAS
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK3 signals through RAS
Interleukin receptor SHC signaling
FLT3 Signaling
Constitutive Signaling by Overexpressed ERBB2
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Potential therapeutics for SARS
Signaling by CSF1 (M-CSF) in myeloid cells
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Signaling by LTK
Drugs
Tiludronic acid
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Mean corpuscular hemoglobin concentration (
29403010
)
Red blood cell fatty acid levels (
25500335
)
Refractive error (
32231278
)
Aseptic loosening in total joint arthroplasty (
31791832
)
Corticobasal degeneration (
26077951
)
Sensorimotor dexterity (
31596458
)
Interacting Genes
118 interacting genes:
AATK
ABL1
ACTN1
ACTN4
BCR
BLNK
BTLA
CAV1
CBL
CCDC88A
CD22
CD247
CD300LF
CD33
CD5
CD72
CD79A
CD79B
CDK1
CEACAM1
CLEC4A
CNKSR1
CSF2RB
CTNNB1
CTNND1
CUZD1
CXCR4
DOK1
EGFR
EPOR
ERBB2
ERBB3
ERBB4
ESR1
FAS
FCGR2B
FCRL3
FGFR4
FHL3
FLT3
GAB2
GHR
GRB2
H2BC3
HOXA10
IFNAR1
IGF1R
IL2RB
IL4R
IL6ST
INSR
IRS2
IRS4
JAK1
JAK2
JAK3
KDR
KHDRBS1
KIR2DL3
KIR2DL5A
KIT
KLRA1P
KLRB1
KLRC1
LAIR1
LAT
LCK
LCP2
LIFR
LILRB2
LILRB4
LMTK2
LYN
MPIG6B
MS4A2
MYH9
NOS1
OLIG1
PAG1
PDGFRB
PECAM1
PIK3R1
PILRA
PILRB
PLCG2
PRKCA
PRKCD
PTK2B
PTK7
PTPN11
PTPRC
ROR1
ROR2
ROS1
SHC1
SIGLEC10
SIGLEC11
SIGLEC12
SIRPA
SLAMF6
SNCA
SOS1
SPATA2
SRC
SSTR2
STAT5B
STAT6
SYK
TFG
TLR10
TMEM62
TNFRSF1A
TRAF3
TRAF6
TREML1
TYK2
VAV1
ZAP70
56 interacting genes:
ABI1
ABI3
ANXA2
ATP6V1E1
BIN1
CAV1
CD19
CD2AP
COPS3
CRK
CRKL
CSF1R
EGFR
EPS8
EPS8L1
EPS8L2
ERBB2
ERBB3
ESR1
FGFR1
FRS2
FYN
GAB1
GRAP
GRB2
HCK
HDLBP
HRAS
ITSN1
ITSN2
LAT2
LCK
MAPK1
MAPK3
MUC1
NCK1
NCK2
PACSIN1
PACSIN3
PIK3R2
PLCG1
PTPN11
PTPN6
RANBP9
RIT2
RRAS
SH3BP5
SH3KBP1
SHC1
SIRPA
SNX18
SNX9
SPTAN1
TNIK
UBASH3A
ZAP70
Entrez ID
5777
6654
HPRD ID
01475
01681
Ensembl ID
ENSG00000111679
ENSG00000115904
Uniprot IDs
P29350
Q53XS4
G5E9C8
Q07889
PDB IDs
1FPR
1GWZ
1X6C
2B3O
2RMX
2YU7
3PS5
4GRY
4GRZ
4GS0
4HJP
4HJQ
6SM5
8YHI
1AWE
1BKD
1DBH
1NVU
1NVV
1NVW
1NVX
1Q9C
1XD2
1XD4
1XDV
2II0
3KSY
4NYI
4NYJ
4NYM
4URU
4URV
4URW
4URX
4URY
4URZ
4US0
4US1
4US2
5OVD
5OVE
5OVF
5OVG
5OVH
5OVI
5WFO
5WFP
5WFQ
5WFR
6BVI
6BVJ
6BVK
6BVL
6BVM
6CUO
6CUP
6CUR
6D55
6D56
6D59
6D5E
6D5G
6D5H
6D5J
6D5L
6D5M
6D5V
6D5W
6EPL
6EPM
6EPN
6EPO
6EPP
6F08
6SCM
6SFR
6V94
6V9F
6V9J
6V9L
6V9M
6V9N
6V9O
6Y44
7AVI
7AVL
7AVS
7AVT
7AVU
7AVV
7KFZ
7UKR
7UKS
8BE2
8BE4
8BE5
8BE6
8BE7
8BE8
8BE9
8BEA
8XJJ
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Signal Transduction
Plasma Membrane
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Tyrosine Kinase Activity
Regulation Of Immune Response
Regulation Of Immune System Process
Enzyme-linked Receptor Protein Signaling Pathway
Immune System Process
Cytokine-mediated Signaling Pathway
Regulation Of Cell Activation
Immune Response-regulating Signaling Pathway
Leukocyte Activation
Cell Activation
Regulation Of MAPK Cascade
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Lymphocyte Activation
Membrane
Lymphocyte Activation
Receptor Complex
Positive Regulation Of MAPK Cascade
Positive Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Protein Kinase Activity
Regulation Of Signal Transduction
Regulation Of T Cell Activation
Regulation Of Intracellular Signal Transduction
Immune Response
Positive Regulation Of Intracellular Signal Transduction
Adaptive Immune Response
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cell Adhesion
Regulation Of Cell-cell Adhesion
Protein Phosphatase Binding
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune Response
Regulation Of Multicellular Organismal Process
Protein Phosphorylation
Regulation Of Leukocyte Proliferation
External Side Of Plasma Membrane
Fc Receptor Signaling Pathway
Kinase Activity
Immune Response-activating Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cell Population Proliferation
B Cell Activation
Mononuclear Cell Differentiation
Phosphotyrosine Residue Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Enzyme-linked Receptor Protein Signaling Pathway
Intracellular Signal Transduction
Regulation Of Signal Transduction
Plasma Membrane
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Signaling
Intracellular Signaling Cassette
Peptidyl-tyrosine Phosphorylation
ERBB Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Cell Communication
Regulation Of Cellular Component Organization
Antigen Receptor-mediated Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Positive Regulation Of MAPK Cascade
Cell Migration
Positive Regulation Of Intracellular Signal Transduction
Immune Response-activating Signaling Pathway
Positive Regulation Of Cellular Component Organization
T Cell Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Regulation Of Immune System Process
Regulation Of Developmental Process
Cell Motility
Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Signaling
Regulation Of Immune Response
Regulation Of Actin Filament-based Process
Response To Growth Factor
Cytosol
Receptor Tyrosine Kinase Binding
Schwann Cell Development
Cytoplasm
Regulation Of Cell Adhesion
Positive Regulation Of Cell Adhesion
Positive Regulation Of Cell Communication
Regulation Of Actin Cytoskeleton Organization
Regulation Of Cytoskeleton Organization
Endocytosis
Regulation Of Anatomical Structure Morphogenesis
Cell Development
MAPK Cascade
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Tagcloud (Intersection)
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