PTPN6 and SIRPA

  • Number of citations of the paper that reports this interaction (PMID 8943344)
  • 69
  • Data Source:
  • BioGRID (two hybrid, x-ray crystallography)
  • HPRD (in vitro)

PTPN6

SIRPA

Gene Name protein tyrosine phosphatase, non-receptor type 6 signal-regulatory protein alpha
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 98 interactors: ABL1 ACTN1 ACTN4 BCR BLNK BTLA C6orf25 CAV1 CBL CD22 CD247 CD300LF CD33 CD5 CD72 CD79A CD79B CEACAM1 CLEC4A CSF2RB CTNNB1 CTNND1 CUZD1 CXCR4 DOK1 EGFR EPOR ESR1 FAS FCGR2B FCRL3 FHL3 FLT3 GAB2 GHR GRB2 HOXA10 IFNAR1 IL2RB IL4R IL6ST INSR IRS2 IRS4 JAK1 JAK2 JAK3 KDR KHDRBS1 KIR2DL3 KIR2DL5A KIT KLRAP1 KLRB1 KLRC1 LAIR1 LCK LCP2 LIFR LILRB2 LILRB4 LYN MS4A2 MYH9 NOS1 PAG1 PECAM1 PIK3R1 PILRA PILRB PRKCA PRKCD PTK2B PTPN11 PTPRC ROS1 SHC1 SIGLEC10 SIGLEC11 SIGLEC12 SIRPA SLAMF6 SOS1 SPATA2 SRC SSTR2 STAT5B STAT6 SYK TFG TLR10 TMEM62 TNFRSF1A TRAF6 TREML1 TYK2 VAV1 ZAP70 12 interactors: CCDC57 CD47 IL1RAP JAK2 KRT15 KRT31 KRT40 NOL3 PTPN11 PTPN6 TRIM2 TRIM27
Entrez ID 5777 140885
HPRD ID 01475 03912
Ensembl ID ENSG00000111679 ENSG00000198053
Uniprot IDs P29350 Q53XS4 P78324
PDB IDs 1FPR 1GWZ 1X6C 2B3O 2RMX 2YU7 3PS5 4GRY 4GRZ 4GS0 4HJP 4HJQ 2JJS 2JJT 2UV3 2WNG
Enriched GO Terms of Interacting Partners?
Tagcloud ?
a2  ag  cd45  chimera  chimeras  chimeric  coupling  diminished  enzymatic  fails  hcp  hemopoietic  initiated  inositol  j45  jurkat  ligation  lymphoid  phosphatase  phospholipase  phosphotyrosine  ptp1c  rescue  shp  shptp  surprisingly  tcr  transduction  unlike 
accelerated  cd47  concert  demonstrates  diabetogenic  displayed  drive  drives  enables  encodes  idd13  idd5  immunopathogenesis  insight  insulitis  islet  locus  mechanistic  nod  paired  potency  potentiate  recapitulates  restricted  t1d  transgene  variations 
Tagcloud (Difference) ?
a2  ag  cd45  chimera  chimeras  chimeric  coupling  diminished  enzymatic  fails  hcp  hemopoietic  initiated  inositol  j45  jurkat  ligation  lymphoid  phosphatase  phospholipase  phosphotyrosine  ptp1c  rescue  shp  shptp  surprisingly  tcr  transduction  unlike 
accelerated  cd47  concert  demonstrates  diabetogenic  displayed  drive  drives  enables  encodes  idd13  idd5  immunopathogenesis  insight  insulitis  islet  locus  mechanistic  nod  paired  potency  potentiate  recapitulates  restricted  t1d  transgene  variations 
Tagcloud (Intersection) ?