ITGA6 and CANX

Number of citations of the paper that reports this interaction (PMID 8163531)
18

Data Source:
HPRD (in vitro, in vivo)

		ITGA6	CANX
Gene Name		integrin, alpha 6	calnexin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Basement Membrane Plasma Membrane Cell-cell Adherens Junction Focal Adhesion External Side Of Plasma Membrane Basal Plasma Membrane Cell Surface Hemidesmosome Filopodium Integrin Alpha6-beta4 Complex	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Ribosome Membrane Axon Dendrite Cytoplasm Melanosome Neuronal Cell Body Dendritic Spine Protein Complex ER-mitochondrion Membrane Contact Site Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Integrin Binding Protein Binding Laminin Binding Metal Ion Binding	Glycoprotein Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Apolipoprotein Binding Ionotropic Glutamate Receptor Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Cell-substrate Junction Assembly Cell-matrix Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Ectodermal Cell Differentiation Positive Regulation Of Cell-substrate Adhesion Single Organismal Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Hemidesmosome Assembly Cell-substrate Adhesion Cellular Response To Extracellular Stimulus Cell Adhesion Mediated By Integrin Cell Junction Assembly Nail Development Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Skin Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Filopodium Assembly Digestive Tract Development Brown Fat Cell Differentiation Leukocyte Migration Cellular Response To Organic Cyclic Compound Renal System Development Amelogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Folding Aging Protein Secretion Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-translational Protein Modification Cellular Protein Metabolic Process Synaptic Vesicle Endocytosis Chaperone-mediated Protein Folding Clathrin-mediated Endocytosis
Pathways		Cell junction organization Syndecan interactions Type I hemidesmosome assembly Collagen formation Laminin interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions Assembly of collagen fibrils and other multimeric structures Basigin interactions Cell surface interactions at the vascular wall	Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Virus Assembly and Release Defective MOGS causes MOGS-CDG (CDG-2b) Influenza Life Cycle Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Assembly of Viral Components at the Budding Site Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Influenza Infection Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle
Drugs			Antihemophilic Factor Tenecteplase
Diseases
GWAS		Alzheimer's disease biomarkers ( 23419831) Prostate cancer ( 19767753)
Protein-Protein Interactions		21 interactors: ADAM9 APP BIN1 CALM1 CANX CD151 CD36 CD63 CD82 COL17A1 GIPC1 GRB2 ITGB1 ITGB4 PCSK5 PLEC PRKCD PXN RABIF RPSA TSPAN4	42 interactors: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F8 FAM107A FSHR GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LPA LRP1 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 TF TG TRA TSHR
Entrez ID		3655	821
HPRD ID		00945	00252
Ensembl ID		ENSG00000091409	ENSG00000127022
Uniprot IDs		P23229	P27824
PDB IDs
Enriched GO Terms of Interacting Partners?		Hemidesmosome Assembly Cell-substrate Junction Assembly Cell Activation Cell-matrix Adhesion Cell Junction Assembly Cell Adhesion Platelet Activation Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Blood Coagulation Hemostasis Response To Wounding Cellular Component Assembly Secretion By Cell Regulation Of Body Fluid Levels Platelet Degranulation Response To Growth Factor Wound Healing Secretion Positive Regulation Of Endocytosis Positive Regulation Of Transport Integrin-mediated Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of MAPK Cascade Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Endocytosis Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of Endocytosis Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Movement Of Cell Or Subcellular Component Establishment Of Localization In Cell Regulation Of Protein Phosphorylation Cell-cell Adhesion Mediated By Integrin Response To Oxidative Stress Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Transport Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Immune System Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway	Response To Stimulus Cell Communication Cellular Response To Stimulus Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Response To Stress Regulation Of Cellular Process Immune System Process Cellular Ion Homeostasis Chemical Homeostasis System Development Cellular Homeostasis Regulation Of Signaling Cellular Chemical Homeostasis Response To External Stimulus Iodide Transport Positive Regulation Of Cell Adhesion Ion Homeostasis Sexual Reproduction Cholesterol Metabolic Process Synaptic Transmission Positive Regulation Of Cell-cell Adhesion Response To Abiotic Stimulus Homeostatic Process Sterol Metabolic Process Multicellular Organismal Development Cellular Cation Homeostasis Response To Organic Cyclic Compound Mating Anatomical Structure Development Cell-cell Signaling Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cognition Regulation Of Establishment Of Protein Localization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Activation Positive Regulation Of Nuclease Activity Rhythmic Process Response To Endoplasmic Reticulum Stress Organ Development Positive Regulation Of Metabolic Process Response To Light Stimulus Cell Adhesion Mediated By Integrin Reproductive Process Reproduction Negative Regulation Of Neuron Differentiation Regulation Of Protein Localization
Tagcloud ?			5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf
Tagcloud (Difference) ?			5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf
Tagcloud (Intersection) ?