ITGA6 and ADAM9

Number of citations of the paper that reports this interaction (PubMedID 15361064)
25

Data Source:
HPRD (in vitro)

		ITGA6	ADAM9
Description		integrin subunit alpha 6	ADAM metallopeptidase domain 9
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alpha6-beta1 Complex Integrin Alpha6-beta4 Complex	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Exosome
	Molecular Function	Protein Binding Insulin-like Growth Factor I Binding Signaling Receptor Activity Neuregulin Binding Cadherin Binding Metal Ion Binding	Metalloendopeptidase Activity Protein Kinase C Binding Integrin Binding Protein Binding Collagen Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity SH3 Domain Binding Laminin Binding Metal Ion Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
	Biological Process	Cell-substrate Junction Assembly Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Ectodermal Cell Differentiation Positive Regulation Of Neuron Projection Development Positive Regulation Of Cell Migration Cell-substrate Adhesion Nail Development Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Skin Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Leukocyte Migration Cell-cell Adhesion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Proteolysis Membrane Protein Ectodomain Proteolysis Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Manganese Ion Cell Migration Protein Processing Keratinocyte Differentiation Positive Regulation Of Cell Migration Membrane Protein Intracellular Domain Proteolysis Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Macrophage Fusion Response To Tumor Necrosis Factor Monocyte Activation Response To Hydrogen Peroxide Amyloid Precursor Protein Catabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Response To Glucocorticoid Positive Regulation Of Keratinocyte Migration Response To Calcium Ion Cellular Response To Lipopolysaccharide
Pathways		Assembly of collagen fibrils and other multimeric structures Basigin interactions Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions Type I hemidesmosome assembly Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Collagen degradation
Drugs			INCB7839
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)	Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Alzheimer's disease biomarkers ( 23419831) Diabetic kidney disease ( 26305897) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Food allergy ( 29030101) Metabolite levels ( 23823483) Peanut allergy ( 29030101) Prostate cancer ( 19767753 31562322)	Basophil count ( 32888494)
Interacting Genes		23 interacting genes: ADAM9 APP BIN1 CALM1 CANX CD151 CD36 CD63 CD82 COL17A1 GIPC1 GRB2 ITGB1 ITGB4 LGALS3BP PCSK5 PLEC PRKCD PXN RABIF RPSA TSPAN4 USP40	10 interacting genes: DYRK1A ITGA3 ITGA6 ITGAV MAD2L2 PRKCD SH3D19 SH3GLB1 SNX9 TNF
Entrez ID		3655	8754
HPRD ID		00945	04091
Ensembl ID		ENSG00000091409	ENSG00000168615
Uniprot IDs		A0A8C8KBL6 A0AAQ5BID9 P23229	Q13443
PDB IDs		7CEB 7CEC
Enriched GO Terms of Interacting Partners?		Cell Adhesion Integrin Binding Cell-substrate Adhesion Hemidesmosome Assembly Hemidesmosome Cell-matrix Adhesion Extracellular Exosome Focal Adhesion Cell Migration Endocytosis Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Endocytosis Plasma Membrane Laminin Binding Membrane Cell Motility Positive Regulation Of Transport Regulation Of Superoxide Metabolic Process Cell Adhesion Mediated By Integrin Vesicle-mediated Transport Low-density Lipoprotein Particle Mediated Signaling Import Into Cell Cell Surface Cell-substrate Junction Assembly Cell-substrate Junction Organization Regulation Of Spontaneous Synaptic Transmission Presynaptic Endocytosis Regulation Of Reactive Oxygen Species Metabolic Process Cell-cell Adhesion Mediated By Integrin Regulation Of Endocytosis Regulation Of Action Potential Cellular Response To Hydroperoxide Positive Regulation Of Cellular Component Organization Positive Regulation Of Supramolecular Fiber Organization Leukocyte Activation Receptor-mediated Endocytosis Vesicle Regulation Of Transport Receptor Internalization Receptor Complex Regulation Of Supramolecular Fiber Organization Insulin Receptor Substrate Binding Cell-cell Junction Response To Manganese Ion Anchoring Junction Cell Activation Mesodermal Cell Differentiation Endothelial Cell Migration Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Biological Quality	Positive Regulation Of Membrane Protein Ectodomain Proteolysis Integrin Complex Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Neuregulin Binding Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Regulation Of Amide Metabolic Process Cell-cell Adhesion Cell Adhesion Regulation Of Catalytic Activity Insulin-like Growth Factor I Binding Positive Regulation Of Catabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Catalytic Activity Cell-matrix Adhesion Protease Binding Filopodium Membrane Positive Regulation Of Phosphate Metabolic Process Cell Surface Regulation Of Membrane Lipid Metabolic Process Negative Regulation Of Lipid Storage Negative Regulation Of Cellular Component Organization Regulation Of Protein Catabolic Process Regulation Of Organelle Organization Regulation Of Apoptotic Signaling Pathway Cell-substrate Adhesion Anchoring Junction Fibronectin Binding Positive Regulation Of Amide Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Adhesion Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Amyloid-beta Formation Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Protein Metabolic Process Histone H3T45 Kinase Activity Leukocyte Migration Positive Regulation Of Apoptotic Process Cell Migration Integrin Alpha6-beta4 Complex Regulation Of Lipid Storage Entry Into Host Cell By A Symbiont-containing Vacuole Opsonin Binding Positive Regulation Of Phospholipid Scramblase Activity
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