ITGA6 and ADAM9

Number of citations of the paper that reports this interaction (PMID 15361064)
10

Data Source:
HPRD (in vitro)

		ITGA6	ADAM9
Gene Name		integrin, alpha 6	ADAM metallopeptidase domain 9
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Basement Membrane Plasma Membrane Cell-cell Adherens Junction Focal Adhesion External Side Of Plasma Membrane Basal Plasma Membrane Cell Surface Hemidesmosome Filopodium Integrin Alpha6-beta4 Complex	Extracellular Space Cytoplasm Focal Adhesion Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane Intrinsic Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding Protein Binding Laminin Binding Metal Ion Binding	Metalloendopeptidase Activity Protein Kinase C Binding Integrin Binding Protein Binding Collagen Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding Laminin Binding
	Biological Process	Cell-substrate Junction Assembly Cell-matrix Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Ectodermal Cell Differentiation Positive Regulation Of Cell-substrate Adhesion Single Organismal Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Hemidesmosome Assembly Cell-substrate Adhesion Cellular Response To Extracellular Stimulus Cell Adhesion Mediated By Integrin Cell Junction Assembly Nail Development Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Skin Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Filopodium Assembly Digestive Tract Development Brown Fat Cell Differentiation Leukocyte Migration Cellular Response To Organic Cyclic Compound Renal System Development Amelogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Activation Of MAPKK Activity Membrane Protein Ectodomain Proteolysis Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Manganese Ion Extracellular Matrix Disassembly Extracellular Matrix Organization Keratinocyte Differentiation Collagen Catabolic Process Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Macrophage Fusion Response To Tumor Necrosis Factor Response To Laminar Fluid Shear Stress Monocyte Activation Response To Hydrogen Peroxide Positive Regulation Of Protein Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis PMA-inducible Membrane Protein Ectodomain Proteolysis Response To Glucocorticoid Positive Regulation Of Keratinocyte Migration Response To Calcium Ion Cellular Response To Lipopolysaccharide
Pathways		Cell junction organization Syndecan interactions Type I hemidesmosome assembly Collagen formation Laminin interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions Assembly of collagen fibrils and other multimeric structures Basigin interactions Cell surface interactions at the vascular wall	Collagen degradation Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Alzheimer's disease biomarkers ( 23419831) Prostate cancer ( 19767753)
Protein-Protein Interactions		21 interactors: ADAM9 APP BIN1 CALM1 CANX CD151 CD36 CD63 CD82 COL17A1 GIPC1 GRB2 ITGB1 ITGB4 PCSK5 PLEC PRKCD PXN RABIF RPSA TSPAN4	9 interactors: ITGA3 ITGA6 ITGAV MAD2L2 PRKCD SH3D19 SH3GLB1 SNX9 TNF
Entrez ID		3655	8754
HPRD ID		00945	04091
Ensembl ID		ENSG00000091409	ENSG00000168615
Uniprot IDs		P23229	Q13443
PDB IDs			1M1V
Enriched GO Terms of Interacting Partners?		Hemidesmosome Assembly Cell-substrate Junction Assembly Cell Activation Cell-matrix Adhesion Cell Junction Assembly Cell Adhesion Platelet Activation Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Blood Coagulation Hemostasis Response To Wounding Cellular Component Assembly Secretion By Cell Regulation Of Body Fluid Levels Platelet Degranulation Response To Growth Factor Wound Healing Secretion Positive Regulation Of Endocytosis Positive Regulation Of Transport Integrin-mediated Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of MAPK Cascade Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Endocytosis Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of Endocytosis Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Movement Of Cell Or Subcellular Component Establishment Of Localization In Cell Regulation Of Protein Phosphorylation Cell-cell Adhesion Mediated By Integrin Response To Oxidative Stress Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Transport Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Immune System Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway	Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Cellular Component Organization Regulation Of Cell Adhesion Negative Regulation Of Signal Transduction Leukocyte Migration Negative Regulation Of Signaling Regulation Of Protein Complex Assembly Extracellular Matrix Organization Regulation Of Cell-cell Adhesion Extracellular Structure Organization Positive Regulation Of Cell Adhesion Regulation Of Protein Catabolic Process Integrin-mediated Signaling Pathway Blood Coagulation Hemostasis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Lipid Storage Positive Regulation Of Protein Oligomerization Positive Regulation Of Cellular Protein Metabolic Process Cell-matrix Adhesion Positive Regulation Of Protein Complex Assembly Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Wound Healing Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Oligomerization Regulation Of Phosphorylation Cell-substrate Adhesion Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Response To Wounding Regulation Of Phosphorus Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Phagocytosis Positive Regulation Of Proteolysis Regulation Of Signal Transduction Cell Migration Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Phosphorylation Regulation Of Lipid Catabolic Process Positive Regulation Of Cell Migration Regulation Of Lipid Storage Positive Regulation Of Cell Motility Cell Motility Positive Regulation Of Protein Modification Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Apoptotic Process
Tagcloud ?			aurka birc5 c11orf30 ccne1 cdc6 cdh1 cpd devoid emsy esr1 fgfr1 holland ikbkb mapt mathematical meaning med1 microdissection mlpa mrc mtdh multiplex numerical p078 prdm14 qiagen salsa top2a traf4
Tagcloud (Difference) ?			aurka birc5 c11orf30 ccne1 cdc6 cdh1 cpd devoid emsy esr1 fgfr1 holland ikbkb mapt mathematical meaning med1 microdissection mlpa mrc mtdh multiplex numerical p078 prdm14 qiagen salsa top2a traf4
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