ITGA6 and GIPC1

Number of citations of the paper that reports this interaction (PMID 11479315)
17

Data Source:
HPRD (in vitro, two hybrid)

		ITGA6	GIPC1
Gene Name		integrin, alpha 6	GIPC PDZ domain containing family, member 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Basement Membrane Plasma Membrane Cell-cell Adherens Junction Focal Adhesion External Side Of Plasma Membrane Basal Plasma Membrane Cell Surface Hemidesmosome Filopodium Integrin Alpha6-beta4 Complex	Cytoplasm Cytosol Brush Border Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Endocytic Vesicle Dendritic Spine Dendritic Shaft Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding Protein Binding Laminin Binding Metal Ion Binding	Actin Binding Receptor Binding Protein Binding Myosin Binding PDZ Domain Binding Protein Homodimerization Activity
	Biological Process	Cell-substrate Junction Assembly Cell-matrix Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Ectodermal Cell Differentiation Positive Regulation Of Cell-substrate Adhesion Single Organismal Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Hemidesmosome Assembly Cell-substrate Adhesion Cellular Response To Extracellular Stimulus Cell Adhesion Mediated By Integrin Cell Junction Assembly Nail Development Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Skin Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Filopodium Assembly Digestive Tract Development Brown Fat Cell Differentiation Leukocyte Migration Cellular Response To Organic Cyclic Compound Renal System Development Amelogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Targeting G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Regulation Of Synaptic Plasticity
Pathways		Cell junction organization Syndecan interactions Type I hemidesmosome assembly Collagen formation Laminin interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions Assembly of collagen fibrils and other multimeric structures Basigin interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Alzheimer's disease biomarkers ( 23419831) Prostate cancer ( 19767753)
Protein-Protein Interactions		21 interactors: ADAM9 APP BIN1 CALM1 CANX CD151 CD36 CD63 CD82 COL17A1 GIPC1 GRB2 ITGB1 ITGB4 PCSK5 PLEC PRKCD PXN RABIF RPSA TSPAN4	31 interactors: ACTN1 ADRB1 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KIF1B LHCGR LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SLC2A1 TGFBR3 TPBG TYRP1 ZFPM1 ZNF408
Entrez ID		3655	10755
HPRD ID		00945	05462
Ensembl ID		ENSG00000091409	ENSG00000123159
Uniprot IDs		P23229	A8K2I7 O14908
PDB IDs
Enriched GO Terms of Interacting Partners?		Hemidesmosome Assembly Cell-substrate Junction Assembly Cell Activation Cell-matrix Adhesion Cell Junction Assembly Cell Adhesion Platelet Activation Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Blood Coagulation Hemostasis Response To Wounding Cellular Component Assembly Secretion By Cell Regulation Of Body Fluid Levels Platelet Degranulation Response To Growth Factor Wound Healing Secretion Positive Regulation Of Endocytosis Positive Regulation Of Transport Integrin-mediated Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of MAPK Cascade Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Endocytosis Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of Endocytosis Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Movement Of Cell Or Subcellular Component Establishment Of Localization In Cell Regulation Of Protein Phosphorylation Cell-cell Adhesion Mediated By Integrin Response To Oxidative Stress Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Transport Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Immune System Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway	Response To External Stimulus Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Positive Regulation Of Phosphorylation Response To Abiotic Stimulus Cell Surface Receptor Signaling Pathway Cell Communication System Development Regulation Of CAMP Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Anatomical Structure Development Positive Regulation Of Metabolic Process Developmental Process Cognition Regulation Of CAMP Metabolic Process Signaling Regulation Of Signal Transduction Signal Transduction Multicellular Organismal Development Movement Of Cell Or Subcellular Component Cell Differentiation Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Learning Or Memory Cell Migration Negative Regulation Of Signal Transduction Activation Of Adenylate Cyclase Activity Anatomical Structure Morphogenesis Regulation Of Cell Development Response To Radiation Tissue Development Cellular Response To Stimulus Regulation Of Synaptic Transmission Cell Motility Regulation Of Apoptotic Process Negative Regulation Of Signaling Positive Regulation Of Adenylate Cyclase Activity Organ Development Response To Stimulus Response To Wounding Positive Regulation Of Cell Development Cell Morphogenesis Involved In Differentiation Response To Light Stimulus Positive Regulation Of Protein Phosphorylation Regulation Of Cell Death Locomotion Regulation Of Cell Differentiation Nervous System Development
Tagcloud ?			adrb1 alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2
Tagcloud (Difference) ?			adrb1 alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2
Tagcloud (Intersection) ?