CANX and SLC6A4

Number of citations of the paper that reports this interaction (PMID 10364189)
13

Data Source:
BioGRID (pull down)

		CANX	SLC6A4
Gene Name		calnexin	solute carrier family 6 (neurotransmitter transporter), member 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Ribosome Membrane Axon Dendrite Cytoplasm Melanosome Neuronal Cell Body Dendritic Spine Protein Complex ER-mitochondrion Membrane Contact Site Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Endomembrane System Neuron Projection Membrane Raft
	Molecular Function	Glycoprotein Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Apolipoprotein Binding Ionotropic Glutamate Receptor Binding Poly(A) RNA Binding Unfolded Protein Binding	Serotonin:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Serotonin Transmembrane Transporter Activity Myosin Binding Syntaxin-1 Binding Rab GTPase Binding Cocaine Binding Protein Homodimerization Activity Nitric-oxide Synthase Binding Actin Filament Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Folding Aging Protein Secretion Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-translational Protein Modification Cellular Protein Metabolic Process Synaptic Vesicle Endocytosis Chaperone-mediated Protein Folding Clathrin-mediated Endocytosis	Response To Hypoxia Serotonin Transport Response To Nutrient Memory Circadian Rhythm Response To Toxic Substance Positive Regulation Of Gene Expression Monoamine Transport Thalamus Development Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Estradiol Social Behavior Vasoconstriction Response To Drug Sperm Ejaculation Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Organ Growth Brain Morphogenesis Protein Oligomerization Protein Homooligomerization Serotonin Uptake Transmembrane Transport Cellular Response To Retinoic Acid Cellular Response To CGMP
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Virus Assembly and Release Defective MOGS causes MOGS-CDG (CDG-2b) Influenza Life Cycle Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Assembly of Viral Components at the Budding Site Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Influenza Infection Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle
Drugs		Antihemophilic Factor Tenecteplase	Fluvoxamine Phentermine Tramadol Citalopram Venlafaxine Atomoxetine Amitriptyline Protriptyline Methylphenidate Imipramine Fluoxetine Duloxetine Dextromethorphan Nortriptyline Amoxapine Fenfluramine Mazindol Trazodone Verapamil Paroxetine Trimipramine Minaprine Pseudoephedrine Cocaine Sertraline Sibutramine Chlorpheniramine Doxepin Nefazodone Desipramine Escitalopram Dexfenfluramine Clomipramine Ephedra MMDA 3,4-Methylenedioxymethamphetamine 4-Methoxyamphetamine Methamphetamine Zimelidine Amineptine Milnacipran Mianserin Tapentadol Desvenlafaxine Dexmethylphenidate Levomilnacipran
Diseases
GWAS
Protein-Protein Interactions		42 interactors: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F8 FAM107A FSHR GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LPA LRP1 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 TF TG TRA TSHR	4 interactors: CALR CANX STX1A YBX1
Entrez ID		821	6532
HPRD ID		00252	01640
Ensembl ID		ENSG00000127022	ENSG00000108576
Uniprot IDs		P27824	B2R7Y7 P31645
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Stimulus Cell Communication Cellular Response To Stimulus Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Response To Stress Regulation Of Cellular Process Immune System Process Cellular Ion Homeostasis Chemical Homeostasis System Development Cellular Homeostasis Regulation Of Signaling Cellular Chemical Homeostasis Response To External Stimulus Iodide Transport Positive Regulation Of Cell Adhesion Ion Homeostasis Sexual Reproduction Cholesterol Metabolic Process Synaptic Transmission Positive Regulation Of Cell-cell Adhesion Response To Abiotic Stimulus Homeostatic Process Sterol Metabolic Process Multicellular Organismal Development Cellular Cation Homeostasis Response To Organic Cyclic Compound Mating Anatomical Structure Development Cell-cell Signaling Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cognition Regulation Of Establishment Of Protein Localization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Activation Positive Regulation Of Nuclease Activity Rhythmic Process Response To Endoplasmic Reticulum Stress Organ Development Positive Regulation Of Metabolic Process Response To Light Stimulus Cell Adhesion Mediated By Integrin Reproductive Process Reproduction Negative Regulation Of Neuron Differentiation Regulation Of Protein Localization	Chaperone-mediated Protein Folding Protein N-linked Glycosylation Via Asparagine Synaptic Vesicle Transport Protein N-linked Glycosylation Peptide Antigen Assembly With MHC Class I Protein Complex Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Establishment Of Vesicle Localization Post-translational Protein Modification Vesicle Localization Antigen Processing And Presentation Of Peptide Antigen Sequestering Of Calcium Ion Regulation Of Cell Division CRD-mediated MRNA Stabilization Protein Transport Protein Folding Vesicle-mediated Transport Antigen Processing And Presentation Establishment Of Protein Localization Aging Positive Regulation Of Dendritic Cell Chemotaxis Establishment Of Organelle Localization Protein Glycosylation Macromolecule Glycosylation Glycosylation Receptor-mediated Endocytosis Glucocorticoid Receptor Signaling Pathway Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Regulation Of Vesicle-mediated Transport Glycoprotein Biosynthetic Process Sequestering Of Metal Ion Organelle Localization Synaptic Vesicle Fusion To Presynaptic Membrane Protein Maturation By Protein Folding Protein Localization Glycoprotein Metabolic Process Posttranscriptional Regulation Of Gene Expression Establishment Of Localization In Cell Response To Gravity Positive Regulation Of Neurotransmitter Secretion Secretion By Cell Cellular Response To Lithium Ion Negative Regulation Of Striated Muscle Cell Differentiation Synaptic Transmission Cellular Localization Glutamate Secretion Secretion Cortical Actin Cytoskeleton Organization Endocytosis MRNA Stabilization
Tagcloud ?		5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf	adjective analyze anxiety authors bp check genotype genotypes homogeneous htt httlpr inventory list mao measuring menopausal mood nevertheless poland polymorphism possibility postmenopausal promoter prove region respondents slight trait vntr
Tagcloud (Difference) ?		5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf	adjective analyze anxiety authors bp check genotype genotypes homogeneous htt httlpr inventory list mao measuring menopausal mood nevertheless poland polymorphism possibility postmenopausal promoter prove region respondents slight trait vntr
Tagcloud (Intersection) ?