CANX and TSHR

Number of citations of the paper that reports this interaction (PubMedID 12383251)
0

Data Source:
HPRD (in vivo)

		CANX	TSHR
Description		calnexin	thyroid stimulating hormone receptor
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Nuclear Membrane Mitochondrial Membrane Melanosome Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Endoplasmic Reticulum Quality Control Compartment Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane Presynapse	Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Receptor Complex
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Metal Ion Binding Unfolded Protein Binding	G Protein-coupled Receptor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding
	Biological Process	Protein Folding Protein Secretion Viral Protein Processing Protein Folding In Endoplasmic Reticulum ERAD Pathway Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Hormone Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone
Pathways		Assembly of Viral Components at the Budding Site MHC class II antigen presentation Interleukin-35 Signalling Calnexin/calreticulin cycle Interleukin-27 signaling Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Hormone ligand-binding receptors G alpha (s) signalling events
Drugs		Antihemophilic factor, human recombinant Tenecteplase Lanoteplase Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate	Thyrotropin alfa
Diseases			Congenital nongoitrous hypothyroidism (CHNG)
GWAS		Daytime sleep phenotypes ( 27126917) Lymphocyte count ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Resting heart rate ( 24680774) White blood cell count ( 27863252 32888494)	Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059 32769997) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Urinary albumin excretion ( 32277301) Visceral fat ( 22589738)
Interacting Genes		47 interacting genes: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F2RL1 F8 FAM107A FSHR GPR35 GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LINC01554 LPA LRP1 LTB4R2 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 SUMO1 TF TG TRA TSHR	38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB SLC9D1 STAT3 SYT1 TMEM119 TSHB
Entrez ID		821	7253
HPRD ID		00252	04537
Ensembl ID		ENSG00000127022	ENSG00000165409
Uniprot IDs		A0A7P0T937 A0A7P0TAE9 A0A7P0TB65 P27824	P16473
PDB IDs			2XWT 3G04 7T9I 7T9M 7T9N 7UTZ 7XW5 7XW6 7XW7
Enriched GO Terms of Interacting Partners?		Plasma Membrane Membrane Signaling Receptor Activity Signal Transduction Cell Surface Protein-hormone Receptor Activity Regulation Of Transport Circulatory System Process G Protein-coupled Peptide Receptor Activity Regulation Of Biological Quality Recycling Endosome Membrane Vascular Process In Circulatory System G Protein-coupled Receptor Activity Integrin Alpha6-beta1 Complex Positive Regulation Of Transport G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Endoplasmic Reticulum Lumen T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Protein Localization To Nuclear Pore Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Localization Clathrin-coated Endocytic Vesicle Membrane Response To Stress Melatonin Receptor Activity Response To Endoplasmic Reticulum Stress Basolateral Plasma Membrane Positive Regulation Of Protein Transport Cell Activation Detection Of Biotic Stimulus Regulation Of Cellular Localization Ligand-gated Monoatomic Ion Channel Activity Regulation Of Establishment Of Protein Localization Conditioned Place Preference Regulation Of Ubiquitin-dependent Protein Catabolic Process System Process Endosome Membrane Alpha-beta T Cell Receptor Complex Associative Learning Immune Response To Tumor Cell Positive Regulation Of Metabolic Process Regulation Of Protein Localization Regulation Of Multicellular Organismal Process Beta-2-microglobulin Binding Bicarbonate Transmembrane Transporter Activity Regulation Of Membrane Potential Receptor Complex Ligand-gated Ion Channel Signaling Pathway Synapse	G-protein Beta/gamma-subunit Complex Binding Guanyl Nucleotide Binding Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein Activity G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Membrane GTPase Activity Adenylate Cyclase Regulator Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway GTP Binding Regulation Of Transport G Protein-coupled Serotonin Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Focal Adhesion Regulation Of Signaling Regulation Of Biological Quality Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Protein Folding In Endoplasmic Reticulum Extracellular Exosome Postsynaptic Signal Transduction D5 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Cell Migration Interleukin-6-mediated Signaling Pathway Positive Regulation Of Transport Regulation Of Cell Motility Protein Localization To Cell-cell Junction Modulation Of Chemical Synaptic Transmission G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Locomotion G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Skeletal Muscle Cell Proliferation Positive Regulation Of Signaling G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Hormone Secretion Glutamatergic Synapse Regulation Of Secretion By Cell Cellular Response To PH Response To Prostaglandin E Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of Insulin Secretion Regulation Of Blood Pressure
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