CANX and LPA

Number of citations of the paper that reports this interaction (PMID 9717723)
1

Data Source:
HPRD (in vivo, in vitro)

		CANX	LPA
Gene Name		calnexin	lipoprotein, Lp(a)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Ribosome Membrane Axon Dendrite Cytoplasm Melanosome Neuronal Cell Body Dendritic Spine Protein Complex ER-mitochondrion Membrane Contact Site Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Extracellular Region Plasma Lipoprotein Particle
	Molecular Function	Glycoprotein Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Apolipoprotein Binding Ionotropic Glutamate Receptor Binding Poly(A) RNA Binding Unfolded Protein Binding	Fibronectin Binding Serine-type Endopeptidase Activity Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Apolipoprotein Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Folding Aging Protein Secretion Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-translational Protein Modification Cellular Protein Metabolic Process Synaptic Vesicle Endocytosis Chaperone-mediated Protein Folding Clathrin-mediated Endocytosis	Proteolysis Lipid Metabolic Process Lipid Transport Receptor-mediated Endocytosis Blood Circulation Negative Regulation Of Endopeptidase Activity Lipoprotein Metabolic Process Small Molecule Metabolic Process
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Virus Assembly and Release Defective MOGS causes MOGS-CDG (CDG-2b) Influenza Life Cycle Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Assembly of Viral Components at the Budding Site Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Influenza Infection Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle
Drugs		Antihemophilic Factor Tenecteplase	Aminocaproic Acid
Diseases
GWAS			Aortic-valve calcification ( 23388002) Cholesterol, total ( 20686565) Coronary heart disease ( 19198611 21378990) HDL cholesterol ( 20686565) LDL cholesterol ( 20686565) Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Lp (a) levels ( 21900290 19124843) Monocyte early outgrowth colony forming units ( 21493818) Protein quantitative trait loci ( 18464913) Response to statin therapy ( 22368281) Response to statin therapy (LDL-C) ( 22331829)
Protein-Protein Interactions		42 interactors: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F8 FAM107A FSHR GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LPA LRP1 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 TF TG TRA TSHR	9 interactors: APOH CANX CELA1 ELANE FBLN5 FGB FN1 LRP2 MMP12
Entrez ID		821	4018
HPRD ID		00252	01063
Ensembl ID		ENSG00000127022	ENSG00000198670
Uniprot IDs		P27824
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Stimulus Cell Communication Cellular Response To Stimulus Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Response To Stress Regulation Of Cellular Process Immune System Process Cellular Ion Homeostasis Chemical Homeostasis System Development Cellular Homeostasis Regulation Of Signaling Cellular Chemical Homeostasis Response To External Stimulus Iodide Transport Positive Regulation Of Cell Adhesion Ion Homeostasis Sexual Reproduction Cholesterol Metabolic Process Synaptic Transmission Positive Regulation Of Cell-cell Adhesion Response To Abiotic Stimulus Homeostatic Process Sterol Metabolic Process Multicellular Organismal Development Cellular Cation Homeostasis Response To Organic Cyclic Compound Mating Anatomical Structure Development Cell-cell Signaling Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cognition Regulation Of Establishment Of Protein Localization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Activation Positive Regulation Of Nuclease Activity Rhythmic Process Response To Endoplasmic Reticulum Stress Organ Development Positive Regulation Of Metabolic Process Response To Light Stimulus Cell Adhesion Mediated By Integrin Reproductive Process Reproduction Negative Regulation Of Neuron Differentiation Regulation Of Protein Localization	Extracellular Matrix Organization Extracellular Structure Organization Wound Healing Response To Wounding Extracellular Matrix Disassembly Blood Coagulation Hemostasis Cell-matrix Adhesion Response To Stress Regulation Of Body Fluid Levels Secretion Cell-substrate Adhesion Vesicle-mediated Transport Collagen Catabolic Process Platelet Degranulation Acute Inflammatory Response Collagen Metabolic Process Transport Multicellular Organismal Macromolecule Metabolic Process Inflammatory Response Multicellular Organismal Metabolic Process Secretion By Cell Neutrophil Mediated Killing Of Fungus Protein Metabolic Process Defense Response Triglyceride Transport Response To Stimulus Regulation Of Growth Regulation Of Cell Proliferation Calcium-independent Cell-matrix Adhesion Endocytosis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Pancreas Morphogenesis Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Response To Yeast Platelet Activation Elastic Fiber Assembly Negative Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Positive Regulation Of Interleukin-8 Biosynthetic Process Killing By Host Of Symbiont Cells Cell Migration Leukocyte Migration Plasminogen Activation Acute Inflammatory Response To Antigenic Stimulus Exocrine Pancreas Development Negative Regulation Of Locomotion Positive Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Fibrinolysis
Tagcloud ?		5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf	adequacy amplified apl attributable cdna concordance disagreement ensure external hematological hospitals implementation inadequacy laboratories malignancies participating pethema pml promyelocytic rearrangements rr satisfactorily scheme sent spanish standardization standardize stressed supporting
Tagcloud (Difference) ?		5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf	adequacy amplified apl attributable cdna concordance disagreement ensure external hematological hospitals implementation inadequacy laboratories malignancies participating pethema pml promyelocytic rearrangements rr satisfactorily scheme sent spanish standardization standardize stressed supporting
Tagcloud (Intersection) ?