CANX and LPA

Number of citations of the paper that reports this interaction (PubMedID 9717723)
0

Data Source:
HPRD (in vitro, in vivo)

		CANX	LPA
Description		calnexin	lipoprotein(a)
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Nuclear Membrane Mitochondrial Membrane Melanosome Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Endoplasmic Reticulum Quality Control Compartment Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane Presynapse	Extracellular Region Plasma Lipoprotein Particle
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Metal Ion Binding Unfolded Protein Binding	Fibronectin Binding Serine-type Endopeptidase Activity Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Apolipoprotein Binding
	Biological Process	Protein Folding Protein Secretion Viral Protein Processing Protein Folding In Endoplasmic Reticulum ERAD Pathway Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis	Proteolysis Lipid Metabolic Process Lipid Transport Blood Circulation
Pathways		Assembly of Viral Components at the Budding Site MHC class II antigen presentation Interleukin-35 Signalling Calnexin/calreticulin cycle Interleukin-27 signaling Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	LDL remodeling
Drugs		Antihemophilic factor, human recombinant Tenecteplase Lanoteplase Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate	Aminocaproic acid
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Lymphocyte count ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Resting heart rate ( 24680774) White blood cell count ( 27863252 32888494)	A body shape index ( 34021172) Abdominal aortic aneurysm ( 32981348) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Aortic valve stenosis ( 29511194) Aortic-valve calcification ( 23388002) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) C-reactive protein levels ( 33339817) Calcific aortic valve stenosis ( 32141789) Cholesterol, total ( 20686565 24097068 25961943 28270201) Coronary artery disease ( 24262325 26343387 28714974 29212778 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease in diabetes ( 30003307) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 19198611 21378990) End stage renal disease x APOL1 genotype interaction ( 29885931) HDL cholesterol ( 20686565 25961943) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heart failure ( 31919418) High density lipoprotein cholesterol levels ( 33339817) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol ( 20686565 24097068 25961943 30275531) LDL cholesterol levels ( 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid or lipoprotein levels ( 23696881) Lipoprotein (a) levels ( 26377243 28512139 30108283 33115273 33730874) Lipoprotein (a) levels in coronary artery disease (percutaneous coronary intervention) ( 31186284) Lipoprotein (a) levels in response to niacin in statin-treated individuals ( 30371334) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms ( 28512139) Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lp (a) levels ( 19124843 21900290) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antithrombotic agents) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Medication use (salicylic acid and derivatives) ( 31015401) Medication use (vasodilators used in cardiac diseases) ( 31015401) Metabolic syndrome ( 31589552) Minimum ankle–brachial index ( 31285632) Monocyte early outgrowth colony forming units ( 21493818) Myocardial infarction ( 26343387 33532862) Parental lifespan ( 29030599 30642433) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's age at death) ( 29227965 31484785) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's age at death or mother's attained age) ( 31484785) Parental longevity (mother's age at death) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Peripheral artery disease ( 31285632) Plasma plasminogen levels ( 25208887) Plateletcrit ( 32888494) Protein quantitative trait loci ( 18464913) Response to statin therapy ( 22368281) Response to statins (LDL cholesterol change) ( 22331829 25350695) Total cholesterol levels ( 28334899 30275531 33339817) Triglyceride levels ( 32154731 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 25961943 30275531) Urinary albumin excretion ( 32277301) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		47 interacting genes: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F2RL1 F8 FAM107A FSHR GPR35 GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LINC01554 LPA LRP1 LTB4R2 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 SUMO1 TF TG TRA TSHR	9 interacting genes: APOH CANX CELA1 ELANE FBLN5 FGB FN1 LRP2 MMP12
Entrez ID		821	4018
HPRD ID		00252	01063
Ensembl ID		ENSG00000127022	ENSG00000198670
Uniprot IDs		A0A7P0T937 A0A7P0TAE9 A0A7P0TB65 P27824	P08519
PDB IDs			1I71 1JFN 1KIV 2FEB 3KIV 4BV5 4BV7 4BVC 4BVD 4BVV 4BVW 4KIV 6RX7 8TCE 8V8Z 8V9B
Enriched GO Terms of Interacting Partners?		Plasma Membrane Membrane Signaling Receptor Activity Signal Transduction Cell Surface Protein-hormone Receptor Activity Regulation Of Transport Circulatory System Process G Protein-coupled Peptide Receptor Activity Regulation Of Biological Quality Recycling Endosome Membrane Vascular Process In Circulatory System G Protein-coupled Receptor Activity Integrin Alpha6-beta1 Complex Positive Regulation Of Transport G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Endoplasmic Reticulum Lumen T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Protein Localization To Nuclear Pore Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Localization Clathrin-coated Endocytic Vesicle Membrane Response To Stress Melatonin Receptor Activity Response To Endoplasmic Reticulum Stress Basolateral Plasma Membrane Positive Regulation Of Protein Transport Cell Activation Detection Of Biotic Stimulus Regulation Of Cellular Localization Ligand-gated Monoatomic Ion Channel Activity Regulation Of Establishment Of Protein Localization Conditioned Place Preference Regulation Of Ubiquitin-dependent Protein Catabolic Process System Process Endosome Membrane Alpha-beta T Cell Receptor Complex Associative Learning Immune Response To Tumor Cell Positive Regulation Of Metabolic Process Regulation Of Protein Localization Regulation Of Multicellular Organismal Process Beta-2-microglobulin Binding Bicarbonate Transmembrane Transporter Activity Regulation Of Membrane Potential Receptor Complex Ligand-gated Ion Channel Signaling Pathway Synapse	Protein Activation Cascade Extracellular Space Elastin Catabolic Process Extracellular Matrix Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Population Proliferation Elastin Metabolic Process Regulation Of Multicellular Organismal Process Proteolysis Fibrinogen Complex Blood Coagulation, Fibrin Clot Formation Extracellular Exosome Extracellular Region Plasminogen Activation Cell-matrix Adhesion Response To Leptin Positive Regulation Of Cell Population Proliferation Serine-type Endopeptidase Activity Heparin Binding Cell-substrate Adhesion Protein Metabolic Process Glycoprotein Catabolic Process Negative Regulation Of Multicellular Organismal Process Zymogen Activation Calcium Ion Binding Biological Process Involved In Interaction With Symbiont Regulation Of Cell-substrate Adhesion Protein Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Blood Coagulation Macromolecule Metabolic Process Extracellular Matrix Disassembly Negative Regulation Of Hemostasis Positive Regulation Of Metabolic Process Negative Regulation Of Coagulation Regulation Of Multicellular Organismal Development Protein Maturation Regulation Of Angiogenesis Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Regulation Of Cell Adhesion Acute Inflammatory Response Platelet Alpha Granule Lumen Collagen Binding Intramembranous Bone Growth Regulation Of Vasculature Development Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Anatomical Structure Morphogenesis
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