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ITGA6 and PLEC
Number of citations of the paper that reports this interaction (PMID
10525545
)
37
Data Source:
HPRD
(two hybrid, in vitro)
ITGA6
PLEC
Gene Name
integrin, alpha 6
plectin
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Basement Membrane
Plasma Membrane
Cell-cell Adherens Junction
Focal Adhesion
External Side Of Plasma Membrane
Basal Plasma Membrane
Cell Surface
Hemidesmosome
Filopodium
Integrin Alpha6-beta4 Complex
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Sarcoplasm
Hemidesmosome
Sarcolemma
Costamere
Intermediate Filament Cytoskeleton
Extracellular Vesicular Exosome
Molecular Function
Integrin Binding
Protein Binding
Laminin Binding
Metal Ion Binding
Actin Binding
Protein Binding
Structural Constituent Of Muscle
Ankyrin Binding
Poly(A) RNA Binding
Biological Process
Cell-substrate Junction Assembly
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Blood Coagulation
Ectodermal Cell Differentiation
Positive Regulation Of Cell-substrate Adhesion
Single Organismal Cell-cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Extracellular Matrix Organization
Hemidesmosome Assembly
Cell-substrate Adhesion
Cellular Response To Extracellular Stimulus
Cell Adhesion Mediated By Integrin
Cell Junction Assembly
Nail Development
Positive Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Skin Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Filopodium Assembly
Digestive Tract Development
Brown Fat Cell Differentiation
Leukocyte Migration
Cellular Response To Organic Cyclic Compound
Renal System Development
Amelogenesis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Apoptotic Process
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Extracellular Matrix Organization
Hemidesmosome Assembly
Cell Junction Assembly
Pathways
Cell junction organization
Syndecan interactions
Type I hemidesmosome assembly
Collagen formation
Laminin interactions
Integrin cell surface interactions
Non-integrin membrane-ECM interactions
Assembly of collagen fibrils and other multimeric structures
Basigin interactions
Cell surface interactions at the vascular wall
Cell junction organization
Apoptotic cleavage of cellular proteins
Type I hemidesmosome assembly
Collagen formation
Programmed Cell Death
Apoptotic execution phase
Caspase-mediated cleavage of cytoskeletal proteins
Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS
Alzheimer's disease biomarkers (
23419831
)
Prostate cancer (
19767753
)
Protein-Protein Interactions
21 interactors:
ADAM9
APP
BIN1
CALM1
CANX
CD151
CD36
CD63
CD82
COL17A1
GIPC1
GRB2
ITGB1
ITGB4
PCSK5
PLEC
PRKCD
PXN
RABIF
RPSA
TSPAN4
17 interactors:
ACTC1
ACTG1
CASP8
CDK1
COL17A1
EGFR
GNB2L1
ITGA6
ITGB4
LMNB1
MAP2
MSN
PLEKHA5
SMAD9
SPTA1
SPTAN1
VIM
Entrez ID
3655
5339
HPRD ID
00945
03180
Ensembl ID
ENSG00000091409
ENSG00000178209
Uniprot IDs
P23229
Q15149
PDB IDs
1MB8
2ODU
2ODV
3F7P
3PDY
3PE0
4GDO
Enriched GO Terms of Interacting Partners
?
Hemidesmosome Assembly
Cell-substrate Junction Assembly
Cell Activation
Cell-matrix Adhesion
Cell Junction Assembly
Cell Adhesion
Platelet Activation
Cell-substrate Adhesion
Extracellular Matrix Organization
Extracellular Structure Organization
Blood Coagulation
Hemostasis
Response To Wounding
Cellular Component Assembly
Secretion By Cell
Regulation Of Body Fluid Levels
Platelet Degranulation
Response To Growth Factor
Wound Healing
Secretion
Positive Regulation Of Endocytosis
Positive Regulation Of Transport
Integrin-mediated Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Phosphorylation
Cellular Response To Growth Factor Stimulus
Regulation Of MAPK Cascade
Protein Transport
Epidermal Growth Factor Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
ERBB Signaling Pathway
Endocytosis
Vesicle-mediated Transport
Establishment Of Protein Localization
Regulation Of Endocytosis
Regulation Of Phosphorus Metabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Movement Of Cell Or Subcellular Component
Establishment Of Localization In Cell
Regulation Of Protein Phosphorylation
Cell-cell Adhesion Mediated By Integrin
Response To Oxidative Stress
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Peptidyl-tyrosine Phosphorylation
Transport
Positive Regulation Of Metabolic Process
Regulation Of Signal Transduction
Immune System Process
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Anatomical Structure Development
Developmental Process
Anatomical Structure Morphogenesis
Movement Of Cell Or Subcellular Component
Cell Differentiation
Tissue Development
Hemidesmosome Assembly
Multicellular Organismal Development
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
System Development
Execution Phase Of Apoptosis
Cell Projection Organization
Locomotion
Cell Development
Axonogenesis
Axon Development
Cell Morphogenesis Involved In Neuron Differentiation
Apoptotic Process
Programmed Cell Death
Neuron Projection Morphogenesis
Cell Death
Death
Epithelium Development
Cell-substrate Junction Assembly
Axon Guidance
Cell Morphogenesis Involved In Differentiation
Nervous System Development
Cell Adhesion
Cell Junction Assembly
Neuron Projection Development
Nail Development
Cell Projection Morphogenesis
Cell Part Morphogenesis
Single Organismal Cell-cell Adhesion
Neuron Development
Negative Regulation Of Cell Death
Chemotaxis
Generation Of Neurons
Amelogenesis
Cell Morphogenesis
Organ Development
Filopodium Assembly
Neurogenesis
Neuron Differentiation
Cytoskeleton Organization
Tube Development
Astrocyte Development
Digestive Tract Development
Response To Ethanol
Response To External Stimulus
Tagcloud
?
actn1
b5
bcat1
carbamoyl
ctnnd1
egfr1
eph
filamin
flna
genego
i2d
interactors
interologous
metadherin
mtdh
nucleolin
pathwaycommons
plectin
pycard
pyd
rpkm
s100a2
serpinb5
signalings
stratifin
subpathway
sum149
sum190
tfrc
Tagcloud (Difference)
?
actn1
b5
bcat1
carbamoyl
ctnnd1
egfr1
eph
filamin
flna
genego
i2d
interactors
interologous
metadherin
mtdh
nucleolin
pathwaycommons
plectin
pycard
pyd
rpkm
s100a2
serpinb5
signalings
stratifin
subpathway
sum149
sum190
tfrc
Tagcloud (Intersection)
?