CANX and EBI3

Number of citations of the paper that reports this interaction (PMID 8551575)
60

Data Source:
HPRD (in vivo)

		CANX	EBI3
Gene Name		calnexin	Epstein-Barr virus induced 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Ribosome Membrane Axon Dendrite Cytoplasm Melanosome Neuronal Cell Body Dendritic Spine Protein Complex ER-mitochondrion Membrane Contact Site Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Extracellular Space Plasma Membrane
	Molecular Function	Glycoprotein Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Apolipoprotein Binding Ionotropic Glutamate Receptor Binding Poly(A) RNA Binding Unfolded Protein Binding	Cytokine Receptor Activity Cytokine Activity Protein Binding Interleukin-27 Receptor Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Folding Aging Protein Secretion Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-translational Protein Modification Cellular Protein Metabolic Process Synaptic Vesicle Endocytosis Chaperone-mediated Protein Folding Clathrin-mediated Endocytosis	Humoral Immune Response Cytokine-mediated Signaling Pathway T-helper 1 Type Immune Response Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Alpha-beta T Cell Proliferation
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Virus Assembly and Release Defective MOGS causes MOGS-CDG (CDG-2b) Influenza Life Cycle Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Assembly of Viral Components at the Budding Site Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Influenza Infection Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle
Drugs		Antihemophilic Factor Tenecteplase
Diseases
GWAS
Protein-Protein Interactions		42 interactors: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F8 FAM107A FSHR GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LPA LRP1 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 TF TG TRA TSHR	6 interactors: CANX GOSR1 IL12A IL27RA MDFI SMAD3
Entrez ID		821	10148
HPRD ID		00252	12051
Ensembl ID		ENSG00000127022	ENSG00000105246
Uniprot IDs		P27824	Q14213
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Stimulus Cell Communication Cellular Response To Stimulus Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Response To Stress Regulation Of Cellular Process Immune System Process Cellular Ion Homeostasis Chemical Homeostasis System Development Cellular Homeostasis Regulation Of Signaling Cellular Chemical Homeostasis Response To External Stimulus Iodide Transport Positive Regulation Of Cell Adhesion Ion Homeostasis Sexual Reproduction Cholesterol Metabolic Process Synaptic Transmission Positive Regulation Of Cell-cell Adhesion Response To Abiotic Stimulus Homeostatic Process Sterol Metabolic Process Multicellular Organismal Development Cellular Cation Homeostasis Response To Organic Cyclic Compound Mating Anatomical Structure Development Cell-cell Signaling Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cognition Regulation Of Establishment Of Protein Localization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Activation Positive Regulation Of Nuclease Activity Rhythmic Process Response To Endoplasmic Reticulum Stress Organ Development Positive Regulation Of Metabolic Process Response To Light Stimulus Cell Adhesion Mediated By Integrin Reproductive Process Reproduction Negative Regulation Of Neuron Differentiation Regulation Of Protein Localization	Positive Regulation Of Cytokine Production Positive Regulation Of Interferon-gamma Production Defense Response To Gram-positive Bacterium Regulation Of Interferon-gamma Production Regulation Of Transcription Factor Import Into Nucleus Regulation Of Cytokine Production Positive Regulation Of Transforming Growth Factor Beta3 Production Extrinsic Apoptotic Signaling Pathway Embryonic Skeletal System Morphogenesis Interleukin-27-mediated Signaling Pathway Response To Other Organism Cell Cycle Arrest Response To Biotic Stimulus Positive Regulation Of Adaptive Immune Response Embryonic Skeletal System Development Evasion Or Tolerance Of Host Defenses By Virus Regulation Of Protein Import Into Nucleus Immune System Process Regulation Of Immune Response Defense Response To Bacterium Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Regulation Of Adaptive Immune Response Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Regulation Of Extracellular Matrix Assembly Positive Regulation Of NK T Cell Activation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Primary MiRNA Processing Regulation Of Protein Phosphorylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Regulation Of Binding Regulation Of Intracellular Protein Transport Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Osteoblast Proliferation SMAD Protein Complex Assembly Skeletal System Morphogenesis Positive Regulation Of Immune Response To Tumor Cell Regulation Of Transforming Growth Factor Beta2 Production Transdifferentiation Regulation Of Isotype Switching To IgG Isotypes Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Catenin Import Into Nucleus Embryonic Organ Morphogenesis Positive Regulation Of Signal Transduction Negative Regulation Of Interleukin-17 Production Positive Regulation Of Alkaline Phosphatase Activity
Tagcloud ?		5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf	c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining foxp3 helios herein neuropilin nodes nrp1 pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger
Tagcloud (Difference) ?		5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf	c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining foxp3 helios herein neuropilin nodes nrp1 pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger
Tagcloud (Intersection) ?