CANX and EDEM1

Number of citations: 0 (PubMedID 12610305)
Data Source: HPRD (in vivo)

		CANX	EDEM1
Name		calnexin	ER degradation enhancing alpha-mannosidase like protein 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Nuclear Membrane Mitochondrial Membrane Melanosome Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Endoplasmic Reticulum Quality Control Compartment Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane Presynapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Aggresome Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Metal Ion Binding Unfolded Protein Binding	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding Protein Binding Misfolded Protein Binding
	Biological Process	Protein Folding Protein Secretion Viral Protein Processing Protein Folding In Endoplasmic Reticulum ERAD Pathway Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis	Carbohydrate Metabolic Process Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Glycoprotein Metabolic Process ERAD Pathway Protein Targeting To ER Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Mannose Trimming
Pathways		Assembly of Viral Components at the Budding Site MHC class II antigen presentation Interleukin-35 Signalling Calnexin/calreticulin cycle Interleukin-27 signaling Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	XBP1(S) activates chaperone genes ER Quality Control Compartment (ERQC)
Drugs		Antihemophilic factor, human recombinant Tenecteplase Lanoteplase Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate	None
GWAS		Daytime sleep phenotypes ( 27126917 ) Lymphocyte count ( 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 ) Resting heart rate ( 24680774 ) White blood cell count ( 27863252 32888494 )	Alzheimer's disease ( 33074286 ) Diverticular disease ( 30177863 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Metabolite levels ( 23823483 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Smoking status (ever vs never smokers) ( 30643258 ) Uterine fibroids ( 28836065 )
Interacting Genes		47 interacting genes: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F2RL1 F8 FAM107A FSHR GPR35 GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LINC01554 LPA LRP1 LTB4R2 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 SUMO1 TF TG TRA TSHR	1 interacting genes: CANX
Entrez ID		821	9695
HPRD ID		00252	09644
Ensembl ID		ENSG00000127022	ENSG00000134109
Uniprot IDs		A0A7P0T937 A0A7P0TAE9 A0A7P0TB65 P27824	Q92611
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Plasma Membrane Membrane Signaling Receptor Activity Signal Transduction Cell Surface Protein-hormone Receptor Activity Regulation Of Transport Circulatory System Process G Protein-coupled Peptide Receptor Activity Regulation Of Biological Quality Recycling Endosome Membrane Vascular Process In Circulatory System G Protein-coupled Receptor Activity Integrin Alpha6-beta1 Complex Positive Regulation Of Transport G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Endoplasmic Reticulum Lumen T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Protein Localization To Nuclear Pore Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Localization Clathrin-coated Endocytic Vesicle Membrane Response To Stress Melatonin Receptor Activity Response To Endoplasmic Reticulum Stress Basolateral Plasma Membrane Positive Regulation Of Protein Transport Cell Activation Detection Of Biotic Stimulus Regulation Of Cellular Localization Ligand-gated Monoatomic Ion Channel Activity Regulation Of Establishment Of Protein Localization Conditioned Place Preference Regulation Of Ubiquitin-dependent Protein Catabolic Process System Process Endosome Membrane Alpha-beta T Cell Receptor Complex Associative Learning Immune Response To Tumor Cell Positive Regulation Of Metabolic Process Regulation Of Protein Localization Regulation Of Multicellular Organismal Process Beta-2-microglobulin Binding Bicarbonate Transmembrane Transporter Activity Regulation Of Membrane Potential Receptor Complex Ligand-gated Ion Channel Signaling Pathway Synapse	Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Melanosome Membrane Secretion By Cell Protein Folding In Endoplasmic Reticulum Secretion Presynapse Positive Regulation Of Lymphocyte Activation Nucleosome Disassembly BBAF Complex Brahma Complex NBAF Complex Protein-DNA Complex Disassembly Regulation Of Lymphocyte Activation NpBAF Complex Positive Regulation Of Cell Activation Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Negative Regulation Of B Cell Apoptotic Process Protein-macromolecule Adaptor Activity Type B Pancreatic Cell Proliferation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Fatty Acid Beta-oxidation Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Phosphatidylinositol 3-kinase Activator Activity Insulin Receptor Binding Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Regulation Of B Cell Apoptotic Process Positive Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Fatty Acid Oxidation Response To Endothelin Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Cellular Response To Endothelin Pore Complex Regulation Of Synaptic Assembly At Neuromuscular Junction Pore Complex Assembly