CANX and GRIA1

Number of citations of the paper that reports this interaction (PMID 10461883)
7

Data Source:
HPRD (in vivo)

		CANX	GRIA1
Gene Name		calnexin	glutamate receptor, ionotropic, AMPA 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Ribosome Membrane Axon Dendrite Cytoplasm Melanosome Neuronal Cell Body Dendritic Spine Protein Complex ER-mitochondrion Membrane Contact Site Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density Cell Junction Dendrite Endocytic Vesicle Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Dendrite Membrane Dendritic Spine Membrane Neuronal Cell Body Dendritic Spine Axonal Spine Neuron Spine Postsynaptic Membrane Recycling Endosome
	Molecular Function	Glycoprotein Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Apolipoprotein Binding Ionotropic Glutamate Receptor Binding Poly(A) RNA Binding Unfolded Protein Binding	Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Protein Binding Glutamate Receptor Activity PDZ Domain Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Folding Aging Protein Secretion Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-translational Protein Modification Cellular Protein Metabolic Process Synaptic Vesicle Endocytosis Chaperone-mediated Protein Folding Clathrin-mediated Endocytosis	Signal Transduction Synaptic Transmission Long-term Memory Receptor Internalization Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Long Term Synaptic Depression
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Virus Assembly and Release Defective MOGS causes MOGS-CDG (CDG-2b) Influenza Life Cycle Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Assembly of Viral Components at the Budding Site Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Influenza Infection Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle	Trafficking of GluR2-containing AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events Activation of AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Transmission across Chemical Synapses
Drugs		Antihemophilic Factor Tenecteplase	L-Glutamic Acid Enflurane Isoflurane Methoxyflurane Desflurane Sevoflurane Perampanel
Diseases
GWAS			Aging (time to event) ( 21782286) Anthropometric traits ( 19260139) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 20592726) Obesity-related traits ( 23251661) Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		42 interactors: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F8 FAM107A FSHR GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LPA LRP1 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 TF TG TRA TSHR	22 interactors: CACNG2 CAMK2G CANX CASP8 CXCR2 DLG1 EPB41L1 EPB41L2 GRIA4 GRID2 GRIK2 GRIP1 GRIPAP1 HOMER1 HSPA5 PICK1 PRKACA PRKCA SDCBP SQSTM1 TANC1 TRPC1
Entrez ID		821	2890
HPRD ID		00252	00695
Ensembl ID		ENSG00000127022	ENSG00000155511
Uniprot IDs		P27824	P42261 Q59GL5
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Stimulus Cell Communication Cellular Response To Stimulus Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Response To Stress Regulation Of Cellular Process Immune System Process Cellular Ion Homeostasis Chemical Homeostasis System Development Cellular Homeostasis Regulation Of Signaling Cellular Chemical Homeostasis Response To External Stimulus Iodide Transport Positive Regulation Of Cell Adhesion Ion Homeostasis Sexual Reproduction Cholesterol Metabolic Process Synaptic Transmission Positive Regulation Of Cell-cell Adhesion Response To Abiotic Stimulus Homeostatic Process Sterol Metabolic Process Multicellular Organismal Development Cellular Cation Homeostasis Response To Organic Cyclic Compound Mating Anatomical Structure Development Cell-cell Signaling Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cognition Regulation Of Establishment Of Protein Localization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Activation Positive Regulation Of Nuclease Activity Rhythmic Process Response To Endoplasmic Reticulum Stress Organ Development Positive Regulation Of Metabolic Process Response To Light Stimulus Cell Adhesion Mediated By Integrin Reproductive Process Reproduction Negative Regulation Of Neuron Differentiation Regulation Of Protein Localization	Synaptic Transmission Cell-cell Signaling Signaling Cell Communication Response To External Stimulus Positive Regulation Of Macrophage Differentiation Glutamate Receptor Signaling Pathway Protein Localization Cortical Actin Cytoskeleton Organization Positive Regulation Of Dense Core Granule Biogenesis Developmental Process Cortical Cytoskeleton Organization Cell Differentiation Nervous System Development Histone H3-T6 Phosphorylation Positive Regulation Of Transport Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Negative Regulation Of Programmed Cell Death Neutrophil Chemotaxis Chemotaxis Anatomical Structure Development Apoptotic Signaling Pathway Receptor Clustering System Development Neutrophil Migration Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Ion Transport Negative Regulation Of Cell Death Granulocyte Chemotaxis Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Anatomical Structure Morphogenesis Intrinsic Apoptotic Signaling Pathway Cell Activation Regulation Of Cellular Localization Regulation Of Apoptotic Process Regulation Of Calcium Ion Transport Cellular Metal Ion Homeostasis Neuron-neuron Synaptic Transmission Regulation Of Signaling Signal Transduction Dendritic Spine Maintenance Response To Cytokine Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cell Death
Tagcloud ?		5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf	acutely arc camksmall cyrillicalpha dioxide durations environ gria2 grin1 grin2a grin2b implied inc inhalation inhaled lifelong m3 periodicals pka pollutant postsynaptic presynaptic psd so2 synapse synaptophysin toxicol ubiquitous wiley
Tagcloud (Difference) ?		5q35 boundary british centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf	acutely arc camksmall cyrillicalpha dioxide durations environ gria2 grin1 grin2a grin2b implied inc inhalation inhaled lifelong m3 periodicals pka pollutant postsynaptic presynaptic psd so2 synapse synaptophysin toxicol ubiquitous wiley
Tagcloud (Intersection) ?