CANX and LCT

Number of citations: 0 (PubMedID 11751874)
Data Source: HPRD (in vivo)

		CANX	LCT
Name		calnexin	lactase
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Nuclear Membrane Mitochondrial Membrane Melanosome Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Endoplasmic Reticulum Quality Control Compartment Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane Presynapse	Plasma Membrane Membrane Apical Plasma Membrane External Side Of Apical Plasma Membrane
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Metal Ion Binding Unfolded Protein Binding	Lactase Activity Catalytic Activity Galactosylceramidase Activity Glucosylceramidase Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Beta-glucosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Protein Homodimerization Activity Cellobiose Glucosidase Activity Phlorizin Hydrolase Activity
	Biological Process	Protein Folding Protein Secretion Viral Protein Processing Protein Folding In Endoplasmic Reticulum ERAD Pathway Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis	Carbohydrate Metabolic Process Lactose Catabolic Process Glycosylceramide Catabolic Process Quercetin Catabolic Process Cellobiose Catabolic Process
Pathways		Assembly of Viral Components at the Budding Site MHC class II antigen presentation Interleukin-35 Signalling Calnexin/calreticulin cycle Interleukin-27 signaling Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Digestion of dietary carbohydrate Intestinal saccharidase deficiencies
Drugs		Antihemophilic factor, human recombinant Tenecteplase Lanoteplase Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate	D-gluconhydroximo-1,5-lactam Nojirimycine Tetrazole alpha-D-Xylopyranose 2-deoxy-2-fluoro-α-D-glucose Gluconolactone (1S,2S,3R,4S,5S)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATE ETHYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATE 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
Diseases		None	Congenital lactase deficiency; Disaccharide intolerance II
GWAS		Daytime sleep phenotypes ( 27126917 ) Lymphocyte count ( 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 ) Resting heart rate ( 24680774 ) White blood cell count ( 27863252 32888494 )	Aspartate aminotransferase levels ( 33547301 ) Blood protein levels ( 30072576 ) Body mass index ( 26426971 ) Distal colorectal cancer ( 33632709 ) Distal/Left-sided colorectal cancer ( 33632709 ) Lactose tolerance test ( 31791255 ) Lung function (FVC) ( 30175238 ) Monocyte count ( 32888494 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) White blood cell count ( 32888494 )
Interacting Genes		47 interacting genes: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F2RL1 F8 FAM107A FSHR GPR35 GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LINC01554 LPA LRP1 LTB4R2 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 SUMO1 TF TG TRA TSHR	2 interacting genes: CANX HSPA5
Entrez ID		821	3938
HPRD ID		00252	04437
Ensembl ID		ENSG00000127022	ENSG00000115850
Uniprot IDs		A0A7P0T937 A0A7P0TAE9 A0A7P0TB65 P27824	P09848
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Plasma Membrane Membrane Signaling Receptor Activity Signal Transduction Cell Surface Protein-hormone Receptor Activity Regulation Of Transport Circulatory System Process G Protein-coupled Peptide Receptor Activity Regulation Of Biological Quality Recycling Endosome Membrane Vascular Process In Circulatory System G Protein-coupled Receptor Activity Integrin Alpha6-beta1 Complex Positive Regulation Of Transport G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Endoplasmic Reticulum Lumen T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Protein Localization To Nuclear Pore Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Localization Clathrin-coated Endocytic Vesicle Membrane Response To Stress Melatonin Receptor Activity Response To Endoplasmic Reticulum Stress Basolateral Plasma Membrane Positive Regulation Of Protein Transport Cell Activation Detection Of Biotic Stimulus Regulation Of Cellular Localization Ligand-gated Monoatomic Ion Channel Activity Regulation Of Establishment Of Protein Localization Conditioned Place Preference Regulation Of Ubiquitin-dependent Protein Catabolic Process System Process Endosome Membrane Alpha-beta T Cell Receptor Complex Associative Learning Immune Response To Tumor Cell Positive Regulation Of Metabolic Process Regulation Of Protein Localization Regulation Of Multicellular Organismal Process Beta-2-microglobulin Binding Bicarbonate Transmembrane Transporter Activity Regulation Of Membrane Potential Receptor Complex Ligand-gated Ion Channel Signaling Pathway Synapse	Protein Folding In Endoplasmic Reticulum Unfolded Protein Binding ERAD Pathway Protein Folding Regulation Of Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Cerebellum Structural Organization Endoplasmic Reticulum Lumen Regulation Of ATF6-mediated Unfolded Protein Response Proteasomal Protein Catabolic Process Protein Catabolic Process Calcium Ion Binding Regulation Of Protein Folding Maintenance Of Protein Localization In Endoplasmic Reticulum PERK-mediated Unfolded Protein Response ER Overload Response Post-translational Protein Targeting To Membrane, Translocation Endoplasmic Reticulum Chaperone Complex Negative Regulation Of PERK-mediated Unfolded Protein Response IRE1-mediated Unfolded Protein Response Cerebellar Purkinje Cell Layer Development Negative Regulation Of IRE1-mediated Unfolded Protein Response Proteolysis Involved In Protein Catabolic Process Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Misfolded Protein Binding Anatomical Structure Arrangement Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Melanosome Membrane Endoplasmic Reticulum Quality Control Compartment Cellular Response To Interleukin-4 Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Protein Serine/threonine Kinase Inhibitor Activity Viral Protein Processing Response To Interleukin-4 Protein Refolding Macromolecule Catabolic Process Endoplasmic Reticulum Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Clathrin-dependent Endocytosis Intracellular Protein Transmembrane Transport Protein Transport COP9 Signalosome Regulation Of Endoplasmic Reticulum Unfolded Protein Response ER-nucleus Signaling Pathway ATP-dependent Protein Folding Chaperone Synaptic Vesicle Endocytosis Integrated Stress Response Signaling Proteolysis Presynaptic Endocytosis