ITGA6 and RABIF

Number of citations of the paper that reports this interaction (PMID 10094488)
9

Data Source:
BioGRID (two hybrid)

		ITGA6	RABIF
Gene Name		integrin, alpha 6	RAB interacting factor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Basement Membrane Plasma Membrane Cell-cell Adherens Junction Focal Adhesion External Side Of Plasma Membrane Basal Plasma Membrane Cell Surface Hemidesmosome Filopodium Integrin Alpha6-beta4 Complex
	Molecular Function	Integrin Binding Protein Binding Laminin Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding
	Biological Process	Cell-substrate Junction Assembly Cell-matrix Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Ectodermal Cell Differentiation Positive Regulation Of Cell-substrate Adhesion Single Organismal Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Hemidesmosome Assembly Cell-substrate Adhesion Cellular Response To Extracellular Stimulus Cell Adhesion Mediated By Integrin Cell Junction Assembly Nail Development Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Skin Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Filopodium Assembly Digestive Tract Development Brown Fat Cell Differentiation Leukocyte Migration Cellular Response To Organic Cyclic Compound Renal System Development Amelogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Small GTPase Mediated Signal Transduction Protein Transport Positive Regulation Of GTPase Activity Membrane Fusion
Pathways		Cell junction organization Syndecan interactions Type I hemidesmosome assembly Collagen formation Laminin interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions Assembly of collagen fibrils and other multimeric structures Basigin interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Alzheimer's disease biomarkers ( 23419831) Prostate cancer ( 19767753)
Protein-Protein Interactions		21 interactors: ADAM9 APP BIN1 CALM1 CANX CD151 CD36 CD63 CD82 COL17A1 GIPC1 GRB2 ITGB1 ITGB4 PCSK5 PLEC PRKCD PXN RABIF RPSA TSPAN4	15 interactors: CCBL2 ITGA2 ITGA3 ITGA5 ITGA6 LAMTOR5 RAB15 RAB1A RAB3A RAB8A RASSF5 REL TCF4 TERF2IP UTP14A
Entrez ID		3655	5877
HPRD ID		00945	04566
Ensembl ID		ENSG00000091409
Uniprot IDs		P23229	P47224 Q53EV1
PDB IDs			1FWQ 2FU5
Enriched GO Terms of Interacting Partners?		Hemidesmosome Assembly Cell-substrate Junction Assembly Cell Activation Cell-matrix Adhesion Cell Junction Assembly Cell Adhesion Platelet Activation Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Blood Coagulation Hemostasis Response To Wounding Cellular Component Assembly Secretion By Cell Regulation Of Body Fluid Levels Platelet Degranulation Response To Growth Factor Wound Healing Secretion Positive Regulation Of Endocytosis Positive Regulation Of Transport Integrin-mediated Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of MAPK Cascade Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Endocytosis Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of Endocytosis Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Movement Of Cell Or Subcellular Component Establishment Of Localization In Cell Regulation Of Protein Phosphorylation Cell-cell Adhesion Mediated By Integrin Response To Oxidative Stress Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Transport Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Immune System Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway	Rab Protein Signal Transduction Cell Adhesion Mediated By Integrin Cell-substrate Adhesion Integrin-mediated Signaling Pathway Protein Secretion Regulation Of Signaling Cellular Response To Stimulus Positive Regulation Of Metabolic Process Protein Localization Vesicle Docking Involved In Exocytosis Vesicle Localization Cellular Protein Localization Ras Protein Signal Transduction Skin Development Vesicle Docking Regulation Of Cellular Localization Membrane Docking Signal Transduction Anatomical Structure Morphogenesis Cell Projection Organization Positive Regulation Of Glycoprotein Metabolic Process Response To Stimulus Positive Regulation Of Cell-substrate Adhesion Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Metabolic Process Signaling Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell Adhesion Regulation Of Vesicle-mediated Transport Formation Of Primary Germ Layer Positive Regulation Of Regulated Secretory Pathway Cell Communication Organelle Localization Cellular Component Maintenance Regulation Of Exocytosis Blood Coagulation Cell Migration Hemostasis Cell-matrix Adhesion Response To Extracellular Stimulus Mesodermal Cell Differentiation Establishment Of Protein Localization Cell Motility Intracellular Protein Transport Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Viral Life Cycle Gastrulation Generation Of Neurons
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